Pregabalin inhibits accelerated defecation and decreased colonic nociceptive threshold in sensitized rats

European Journal of Pharmacology

Volumn 643, Issue 1, 2010, Pages 107-112

  Ohashi Doi, Katsuyo ^a   Gale, Jeremy D ^b   Kurebayashi, Yoichi ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Defecation; Irritable bowel syndrome; Pregabalin; Visceral hypersensitivity

Indexed keywords

PREGABALIN; TRINITROBENZENESULFONIC ACID;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASCENDING COLON; COLON DILATATION; CONTROLLED STUDY; DEFECATION DISORDER; DEFECATION HABIT; DESCENDING COLON; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; IMMOBILIZATION STRESS; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; RAT; ROTAROD TEST; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 77955058437     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.06.014     Document Type: Article

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