Identification and analysis of an early diagnostic marker for malignant melanoma: ZAR1 intra-genic differential methylation

Journal of Dermatological Science

Volumn 59, Issue 2, 2010, Pages 98-106

  Shinojima, Yui ^a   Terui, Tadashi ^a   Hara, Hiroyuki ^a   Kimura, Makoto ^b   Igarashi, Jun ^b   Wang, Xiaofei ^b   Kawashima, Hiroyuki ^a   Kobayashi, Yujin ^a   Muroi, Satomi ^a   Hayakawa, Satoshi ^a   Esumi, Mariko ^a   Fujiwara, Kyoko ^a,c   Ghosh, Srimoyee ^c   Yamamoto, Tatsuo ^a   Held, William ^c   Nagase, Hiroki ^a,b,c  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NIHON UNIVERSITY   (Japan)

^c ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Aberrant methylation; Differentially methylated regions (DMRs); Malignant melanoma; Zygote arrest 1 (ZAR1)

Indexed keywords

GENE PRODUCT; HISTONE; UNCLASSIFIED DRUG; ZYGOTE ARREST 1 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CHROMATIN IMMUNOPRECIPITATION; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EARLY DIAGNOSIS; EXON; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; MELANOCYTIC NEVUS; MELANOMA; MOUSE; NONHUMAN; OOCYTE; PHASE TRANSITION; PRIORITY JOURNAL; PROMOTER REGION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; CELL LINE; CELL LINE, TUMOR; DIAGNOSIS, DIFFERENTIAL; DNA METHYLATION; EGG PROTEINS; HISTONES; HUMANS; MELANOCYTES; MELANOMA; MICE; MICE, INBRED C57BL; NEVUS; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 77955055262     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2010.04.016     Document Type: Article

References (17)

1. Cancer facts & figures; 2009. Atlanta: American Cancer Society.
2. Farmer E.R., Gonin R., Hanna M.P. Discordance in the histopathologic diagnosis of melanoma and melanocytic nevi between expert pathologists. Hum Pathol 1996, 27:528-531.
3. Chin L., Garraway L.A., Fisher D.E. Malignant melanoma: genetics and therapeutics in the genomic era. Genes Dev 2006, 20:2149-2182.
4. Rothhammer T., Bosserhoff A.K. Epigenetic events in malignant melanoma. Pigment Cell Res 2007, 20:92-111.
5. Robertson K.D. DNA methylation and human disease. Nat Rev Genet 2005, 6:597-610.
6. Jones P.A. The DNA methylation paradox. Trend Genet 1999, 15:34-37.
7. Salem C.E., Markl I.D., Bender C.M., Gonzales F.A., Jones P.A., Liang G. PAX6 methylation and ectopic expression in human tumor cells. Int J Cancer 2000, 15:179-185.
8. Smith J.F., Mahmood S., Song F., Morrow A., Smiraglia D.J., Zhang X., et al. Identification of DNA methylation in 3' genomic regions that are associated with upregulation of gene expression in colorectal cancer. Epigenetics 2007, 2:161-172.
9. LaVoie H.A. Epigenetic control of ovarian function: the emerging role of histone modifications. Mol Cell Endocrinol 2005, 243:12-18.
10. Smiraglia D.J., Kazhiyur-Mannar R., Oakes C.C., Wu Y.Z., Liang P., Ansari T., et al. Restriction landmark genomic scanning (RLGS) spot identification by second generation virtual RLGS in multiple genomes with multiple enzyme combinations. BMC Genomics 2007, 30:446.
11. Ehrich M., Nelson M.R., Stanssens P., Zabeau M., Liloglou T., Xinarianos G., et al. Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry. Proc Natl Acad Sci USA 2005, 102:15785-15790.
12. Wu X., Viveiros M.M., Eppig J.J., Bai Y., Fitzpatrick S.L., Matzuk M.M. Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition. Nature Genet 2003, 33:187-191.
13. Wu X., Wang P., Brown C.A., Zilinski C.A., Matzuk M.M. Zygote arrest 1 (Zar1) is an evolutionarily conserved gene expressed in vertebrate ovaries. Biol Reprod 2003, 69:861-867.
14. Sims R.J., Chen C.F., Santos-Rosa H., Kouzarides T., Patel S.S., Reinberg D. Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. J Biol Chem 2005, 280:41789-41792.
15. Wysocka J., Swigut T., Milne T.A., Dou Y., Zhang X., Burlingame A.L., et al. WDR5 associates with histone H3 methylated at K4 and is essential for H3K4 methylation and vertebrate development. Cell 2005, 121:859-872.
16. Ringrose L., Ehret H., Paro R. Distinct contributions of histone H3 lysine 9 and 27 methylation to locus-specific stability of polycomb complexes. Mol Cell 2004, 16:641-653.
17. Bernstein B.E., Mikkelsen T.S., Xie X., Kamal M., Huebert D.J., Cuff J., et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006, 125:315-326.