Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition

Nature Genetics

Volumn 33, Issue 2, 2003, Pages 187-191

  Wu, Xuemei ^a   Viveiros, Maria M ^b,d   Eppig, John J ^b   Bai, Yuchen ^c   Fitzpatrick, Susan L ^c   Matzuk, Martin M ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b JACKSON LABORATORY   (United States)

^c PFIZER INC   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA REPLICATION; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; FERTILITY; GENE; GENE FUNCTION; GENE ZAR1; IMMUNOHISTOCHEMISTRY; MOUSE; MOUSE STRAIN; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; OOCYTE DEVELOPMENT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION; ZYGOTE;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; BLOTTING, WESTERN; CLONING, MOLECULAR; DNA REPLICATION; EGG PROTEINS; EMBRYO; FEMALE; FERTILITY; FERTILIZATION IN VITRO; GENE EXPRESSION REGULATION; GENE LIBRARY; GOATS; MALE; MEIOSIS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; OOCYTES; PREGNANCY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; SPERMATIDS; STEM CELLS; ZYGOTE;

ANIMALIA; MAMMALIA;

EID: 0037313184     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1079     Document Type: Article

References (29)

1. Latham, K.E. Mechanisms and control of embryonic genome activation in mammalian embryos, Int. Rev. Cytol. 193, 71-124 (1999).
2. Latham, K.E. & Schultz, R.M. Embryonic genome activation. Front. Biosci. 6, 748-759 (2001).
3. Schultz, R.M. Regulation of zygotic gene activation in the mouse. Bioessays 15, 531-538 (1993).
4. Aoki, F., Worrad, D.M. & Schultz, R.M. Regulation of transcriptional activity during the first and second cell cycles in the pre-implantation mouse embryo. Dev. Biol. 181, 296-307 (1997).
5. Matzuk, M.M., Burns, K., Viveiros, M.M. & Eppig, J. Intercellular communication in the mammalian ovary: oocytes carry the conversation. Science 296, 2178-2180 (2002).
6. Matzuk, M.M. & Lamb, D.J. Genetic dissection of mammalian fertility pathways. Nat. Med. 8, S41-S49 (2002).
7. Aasland, R., Gibson, T.J. & Stewart, A.F. The PHD finger: implications for chromatin-mediated transcriptional regulation. Trends Biochem. Sci. 20, 56-59 (1995).
8. Conover, J.C., Temeles, G.L., Zimmermann, J.W., Burke, B. & Schultz, R.M. Stage-specific expression of a family of proteins that are major products of zygotic gene activation in the mouse embryo. Dev. Biol. 144, 392-404 (1991).
9. Tong, Z.B. et al. Mater, a maternal effect gene required for early embryonic development in mice. Nat. Genet. 26, 267-268 (2000).
10. Howell, C.Y. et al. Genomic imprinting disrupted by a maternal-effect mutation in the Dnmt1 gene. Cell 104, 829-838 (2001).
11. Prolla, T.A. et al. Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Nat. Genet. 18, 276-279 (1998).
12. Christians, E., Davis, A.A., Thomas, S.D. & Benjamin, I.J. Maternal effect of Hsf1 on reproductive success. Nature 407, 693-694 (2000).
13. Dong, J. et al. Growth differentiation factor 9 is required during early ovarian folliculogenesis. Nature 383, 531-535 (1996).
14. Gibbons, R.J. et al. Mutations in transcriptional regulator ATRX establish the functional significance of a PHD-like domain. Nat. Genet. 17, 146-148 (1997).
15. Capili, A.D., Schultz, D.C., Rauscher, I.F. & Borden, K.L. Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains. EMBO J. 20, 165-177 (2001).
16. Kumar, T.R. et al. Reproductive defects in γ-glutamyl transpeptidase-deficient mice. Endocrinology 141, 4270-4277 (2000).
17. Flach, G., Johnson, M.H., Braude, P.R., Taylor, R.A. & Bolton, V.N. The transition from maternal to embryonic control in the two-cell mouse embryo. EMBO J. 1, 681-686(1982).
18. Tong, Z.B., Bondy, C.A., Zhou, J. & Nelson, L.M. A human homologue of mouse Mater, a maternal-effect gene essential for early embryonic development. Hum. Reprod. 17, 903-911 (2002).
19. Albrecht, U., Eichele, G., Helms, J.A. & Lu, H.C. Visualization of gene expression patterns by in situ hybridization in Molecular and Cellular Methods in Developmental Toxicology (ed. Daston, G.R) 23-48 (CRC Press, Boca Raton, Florida, 1997).
20. Elvin, J.A., Yan, C., Wang, P., Nishimori, K. & Matzuk, M.M. Molecular characterization of the follicle defects in the growth differentiation factor 9-deficient ovary. Mol. Endocrinol. 13, 1018-1034 (1999).
21. Matzuk, M.M. & Bradley, A. Structure of the mouse activin receptor type II gene. Biochem. Biophys. Res. Commun. 185, 404-413 (1992).
22. Matzuk, M.M., Finegold, MJ., Su, J.-G.J., Hsueh, A.J.W. & Bradley, A. α-Inhibin is a tumor-suppressor gene with gonadal specificity in mice. Nature 360, 313-319 (1992).
23. Bradley, A. Production and analysis of chimeric mice-teratocarcinomas and embryonic stem cells: a practical approach, in Production and Analysis of Chimeric Mice (ed. Robinson, E.J.) 113-151 (Oxford, London, 1987).
24. Eppig, J.J. Mouse oocyte maturation, fertilization, and pre-implantation development in vitro in A Comparative Methods Approach to the Study of Oocytes and Embryos (ed. Richter, J.D.) 3-9 (Oxford University Press, Oxford, 1999).
25. Yan, W. et al. Identification of Gasz, an evolutionarily conserved gene expressed exclusively in germ cells and encoding a protein with four ankyrin repeats, a sterile-alpha motif, and a basic leucine zipper. Mol. Endocrinol. 16, 1168-1184 (2002).
26. Ferreira, J. & Carmo-Fonseca, M. Genome replication in early mouse embryos follows a defined temporal and spatial order. J. Cell. Sci. 110, 889-897 (1997).
27. Yaffe, M.B. et al. A motif-based profile scanning approach for genome-wide prediction of signaling pathways. Nat. Biotechnol. 19, 348-353 (2001).
28. Elvin, J.A., Clark, A.T., Wang, P., Wolfman, N.M. & Matzuk, M.M. Paracrine actions of growth differentiation factor 9 in the mammalian ovary. Mol. Endocrinol. 13, 1035-1048 (1999).
29. Pedersen, T. & Peters, H. Proposal for a classification of oocytes and follicles in the mouse ovary. J. Reprod. Fertil. 17, 555-557 (1968).