-
1
-
-
52449123919
-
Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity
-
Farooqi IS, O'Rahilly S. Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity. Nat Clin Pract Endocrinol Metab 2008;4:569-577.
-
(2008)
Nat Clin Pract Endocrinol Metab
, vol.4
, pp. 569-577
-
-
Farooqi, I.S.1
O'Rahilly, S.2
-
2
-
-
0037101841
-
A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism
-
Challis BG, Pritchard LE, Creemers JW et al. A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism. Hum Mol Genet 2002;11:1997-2004.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 1997-2004
-
-
Challis, B.G.1
Pritchard, L.E.2
Creemers, J.W.3
-
3
-
-
12144289073
-
Melanocortin-4 receptor gene variant I103 is negatively associated with obesity
-
Geller F, Reichwald K, Dempfle A et al. Melanocortin-4 receptor gene variant I103 is negatively associated with obesity. Am J Hum Genet 2004;74:572-581.
-
(2004)
Am J Hum Genet
, vol.74
, pp. 572-581
-
-
Geller, F.1
Reichwald, K.2
Dempfle, A.3
-
4
-
-
34547839796
-
Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: The two facets of a Janus obesity gene
-
Stutzmann F, Vatin V, Cauchi S et al. Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene. Hum Mol Genet 2007;16:1837-1844.
-
(2007)
Hum Mol Genet
, vol.16
, pp. 1837-1844
-
-
Stutzmann, F.1
Vatin, V.2
Cauchi, S.3
-
5
-
-
44349142294
-
Common variants near MC4R are associated with fat mass, weight and risk of obesity
-
Loos RJ, Lindgren CM, Li S et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008;40:768-775.
-
(2008)
Nat Genet
, vol.40
, pp. 768-775
-
-
Loos, R.J.1
Lindgren, C.M.2
Li, S.3
-
6
-
-
58149163141
-
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
-
Thorleifsson G, Walters GB, Gudbjartsson DF et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 2009;41:18-24.
-
(2009)
Nat Genet
, vol.41
, pp. 18-24
-
-
Thorleifsson, G.1
Walters, G.B.2
Gudbjartsson, D.F.3
-
7
-
-
1442349990
-
A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2
-
Meyre D, Lecoeur C, Delplanque J et al. A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2. Diabetes 2004;53:803-811.
-
(2004)
Diabetes
, vol.53
, pp. 803-811
-
-
Meyre, D.1
Lecoeur, C.2
Delplanque, J.3
-
8
-
-
0032532480
-
Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1
-
Michaud JL, Rosenquist T, May NR, Fan CM. Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1. Genes Dev 1998;12:3264-3275.
-
(1998)
Genes Dev
, vol.12
, pp. 3264-3275
-
-
Michaud, J.L.1
Rosenquist, T.2
May, N.R.3
Fan, C.M.4
-
9
-
-
27544450765
-
Divergence of melanocortin pathways in the control of food intake and energy expenditure
-
Balthasar N, Dalgaard LT, Lee CE et al. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 2005;123:493-505.
-
(2005)
Cell
, vol.123
, pp. 493-505
-
-
Balthasar, N.1
Dalgaard, L.T.2
Lee, C.E.3
-
10
-
-
33748752620
-
Single-minded view of melanocortin signaling in energy homeostasis
-
Baskin DG. Single-minded view of melanocortin signaling in energy homeostasis. Endocrinology 2006;147:4539-4541.
-
(2006)
Endocrinology
, vol.147
, pp. 4539-4541
-
-
Baskin, D.G.1
-
11
-
-
3042744036
-
Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice
-
Holder JL Jr, Zhang L, Kublaoui BM et al. Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice. Am J Physiol Endocrinol Metab 2004;287:E105-E113.
-
(2004)
Am J Physiol Endocrinol Metab
, vol.287
-
-
Holder Jr., J.L.1
Zhang, L.2
Kublaoui, B.M.3
-
12
-
-
33748742610
-
Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons
-
Kublaoui BM, Holder JL Jr, Gemelli T, Zinn AR. Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons. Mol Endocrinol 2006;20:2483-2492.
-
(2006)
Mol Endocrinol
, vol.20
, pp. 2483-2492
-
-
Kublaoui, B.M.1
Holder Jr., J.L.2
Gemelli, T.3
Zinn, A.R.4
-
13
-
-
0035393437
-
Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus
-
Michaud JL, Boucher F, Melnyk A et al. Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus. Hum Mol Genet 2001;10:1465-1473.
-
(2001)
Hum Mol Genet
, vol.10
, pp. 1465-1473
-
-
Michaud, J.L.1
Boucher, F.2
Melnyk, A.3
-
14
-
-
33745959078
-
Adenoviral-mediated modulation of Sim1 expression in the paraventricular nucleus affects food intake
-
Yang C, Gagnon D, Vachon P et al. Adenoviral-mediated modulation of Sim1 expression in the paraventricular nucleus affects food intake. J Neurosci 2006;26:7116-7120.
-
(2006)
J Neurosci
, vol.26
, pp. 7116-7120
-
-
Yang, C.1
Gagnon, D.2
Vachon, P.3
-
15
-
-
33748746056
-
SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake
-
Kublaoui BM, Holder JL Jr, Tolson K P, Gemelli T, Zinn AR. SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake. Endocrinology 2006;147:4542-4549.
-
(2006)
Endocrinology
, vol.147
, pp. 4542-4549
-
-
Kublaoui, B.M.1
Holder Jr., J.L.2
Tolson, K.P.3
Gemelli, T.4
Zinn, A.R.5
-
16
-
-
0034016043
-
Profound obesity associated with a balanced translocation that disrupts the SIM1 gene
-
Holder JL Jr, Butte N F, Zinn AR. Profound obesity associated with a balanced translocation that disrupts the SIM1 gene. Hum Mol Genet 2000;9:101-108.
-
(2000)
Hum Mol Genet
, vol.9
, pp. 101-108
-
-
Holder Jr., J.L.1
Butte, N.F.2
Zinn, A.R.3
-
17
-
-
58149163142
-
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
-
Willer CJ, Speliotes EK, Loos RJ et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009;41:25-34.
-
(2009)
Nat Genet
, vol.41
, pp. 25-34
-
-
Willer, C.J.1
Speliotes, E.K.2
Loos, R.J.3
-
18
-
-
59149097625
-
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
-
Meyre D, Delplanque J, Chèvre JC et al. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet 2009;41:157-159.
-
(2009)
Nat Genet
, vol.41
, pp. 157-159
-
-
Meyre, D.1
Delplanque, J.2
Chèvre, J.C.3
-
19
-
-
67650224470
-
Common variation in SIM1 is reproducibly associated with BMI in Pima Indians
-
Traurig M, Mack J, Hanson RL et al. Common variation in SIM1 is reproducibly associated with BMI in Pima Indians. Diabetes 2009;58: 1682-1689.
-
(2009)
Diabetes
, vol.58
, pp. 1682-1689
-
-
Traurig, M.1
MacK, J.2
Hanson, R.L.3
-
20
-
-
0025765272
-
Body mass index variations: Centiles from birth to 87 years
-
Rolland-Cachera M F, Cole TJ, Sempé M et al. Body mass index variations: centiles from birth to 87 years. Eur J Clin Nutr 1991;45:13-21.
-
(1991)
Eur J Clin Nutr
, vol.45
, pp. 13-21
-
-
Rolland-Cachera, M.F.1
Cole, T.J.2
Sempé, M.3
-
21
-
-
0029146711
-
Defining childhood obesity: The relative body mass index (BMI)
-
European Childhood Obesity group
-
Poskitt EM. Defining childhood obesity: the relative body mass index (BMI). European Childhood Obesity group. Acta Paediatr 1995;84:961-963.
-
(1995)
Acta Paediatr
, vol.84
, pp. 961-963
-
-
Poskitt, E.M.1
-
22
-
-
0033646938
-
Macronutrient energy intake and adiposity in non obese prepubertal children aged 5-11 y (the Fleurbaix Laventie Ville Santé Study)
-
Maillard G, Charles MA, Lafay L et al. Macronutrient energy intake and adiposity in non obese prepubertal children aged 5-11 y (the Fleurbaix Laventie Ville Santé Study). Int J Obes Relat Metab Disord 2000;24: 1608-1617.
-
(2000)
Int J Obes Relat Metab Disord
, vol.24
, pp. 1608-1617
-
-
Maillard, G.1
Charles, M.A.2
Lafay, L.3
-
23
-
-
33744948613
-
The INS VNTR locus does not associate with smallness for gestational age (SGA) but interacts with SGA to increase insulin resistance in young adults
-
Vu-Hong TA, Durand E, Deghmoun S et al. The INS VNTR locus does not associate with smallness for gestational age (SGA) but interacts with SGA to increase insulin resistance in young adults. J Clin Endocrinol Metab 2006;91:2437-2440.
-
(2006)
J Clin Endocrinol Metab
, vol.91
, pp. 2437-2440
-
-
Vu-Hong, T.A.1
Durand, E.2
Deghmoun, S.3
-
24
-
-
0032145872
-
SUpplementation en VItamines et Minéraux AntioXydants
-
Hercberg S, Preziosi P, Briançon S et al. A primary prevention trial using nutritional doses of antioxidant vitamins and minerals in cardiovascular diseases and cancers in a general population: the SU.VI.MAX study\design, methods, and participant characteristics. SUpplementation en VItamines et Minéraux AntioXydants. Control Clin Trials 1998;19:336-351.
-
(1998)
Control Clin Trials
, vol.19
, pp. 336-351
-
-
Hercberg, S.1
Preziosi, P.2
Briançon, S.3
-
25
-
-
33847257845
-
Studies of the SIM1 gene in relation to human obesity and obesity-related traits
-
Hung CC, Luan J, Sims M et al. Studies of the SIM1 gene in relation to human obesity and obesity-related traits. Int J Obes (Lond) 2007;31: 429-434.
-
(2007)
Int J Obes (Lond)
, vol.31
, pp. 429-434
-
-
Hung, C.C.1
Luan, J.2
Sims, M.3
-
26
-
-
0033989154
-
ARNT2 acts as the dimerization partner of SIM1 for the development of the hypothalamus
-
Michaud JL, DeRossi C, May NR, Holdener BC, Fan CM. ARNT2 acts as the dimerization partner of SIM1 for the development of the hypothalamus. Mech Dev 2000;90:253-261.
-
(2000)
Mech Dev
, vol.90
, pp. 253-261
-
-
Michaud, J.L.1
Derossi, C.2
May, N.R.3
Holdener, B.C.4
Fan, C.M.5
-
27
-
-
0037155908
-
Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors
-
Woods SL, Whitelaw ML. Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors. J Biol Chem 2002;277:10236-10243.
-
(2002)
J Biol Chem
, vol.277
, pp. 10236-10243
-
-
Woods, S.L.1
Whitelaw, M.L.2
|