Abnormal CEACAM6 expression in crohn disease patients favors gut colonization and inflammation by adherent-invasive E. coli

Virulence

Volumn 1, Issue 4, 2010, Pages 281-282

  Barnich, Nicolas ^a,b   Darfeuille Michaud, Arlette ^a,b  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b CBRV   (France)

Author keywords

Adherent invasive E. coli; CEACAM6; Colonisation; Crohn disease; Inflammation; Type 1 pili

Indexed keywords

CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 6; TUMOR NECROSIS FACTOR ALPHA;

ADHERENT INVASIVE ESCHERICHIA COLI; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL VIRULENCE; CELL ADHESION; CROHN DISEASE; ESCHERICHIA COLI; HOST CELL; HUMAN; INTESTINE EPITHELIUM CELL; NONHUMAN; PROTEIN EXPRESSION;

ESCHERICHIA COLI; MUS MUSCULUS;

EID: 77955046881     PISSN: 21505594     EISSN: 21505608     Source Type: Journal    
DOI: 10.4161/viru.1.4.11510     Document Type: Article

References (21)

1. Conte MP, Schippa S, Zamboni I, Penta M, Chiarini F, Seganti L, et al. Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease. Gut 2006; 55:1760-7.
2. Darfeuille-Michaud A, Neut C, Barnich N, Lederman E, Di Martino P, Desreumaux P, et al. Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease. Gastroenterology 1998; 115:1405-13.
3. Kotlowski R, Bernstein CN, Sepehri S, Krause DO. High prevalence of Escherichia coli belonging to the B2 + D phylogenetic group in inflammatory bowel disease. Gut 2007; 56:669-75.
4. Martin HM, Campbell BJ, Hart CA, Mpofu C, Nayar M, Singh R, et al. Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer. Gastroenterology 2004; 127:80-93.
5. Mylonaki M, Rayment NB, Rampton DS, Hudspith BN, Brostoff J. Molecular characterization of rectal mucosa-associated bacterial flora in inflammatory bowel disease. Inflamm Bowel Dis 2005; 11:481-7.
6. Neut C, Bulois P, Desreumaux P, Membré JM, Lederman E, Gambiez L, et al. Changes in the bacterial flora of the neoterminal ileum after ileocolonic resection for Crohn's disease. Am J Gastroenterol 2002; 97:939-46.
7. Swidsinski A, Ladhoff A, Pernthaler A, Swidsinski S, Loening-Baucke V, Ortner M, et al. Mucosal flora in inflammatory bowel disease. Gastroenterology 2002; 122:44-54.
8. Darfeuille-Michaud A, Boudeau J, Bulois P, Neut C, Glasser AL, Barnich N, et al. High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease. Gastroenterology 2004; 127:412-21.
9. Martinez-Medina M, Aldeguer X, Lopez-Siles M, González-Huix F, López-Oliu C, Dahbi G, et al. Molecular diversity of Escherichia coli in the human gut: new ecological evidence supporting the role of adherent-invasive E. coli (AIEC) in Crohn's disease. Inflamm Bowel Dis 2009; 15:872-82.
10. Baumgart M, Dogan B, Rishniw M, Weitzman G, Bosworth B, Yantiss R, et al. Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum. Isme J 2007; 1:403-18.
11. Eaves-Pyles T, Allen CA, Taormina J, Swidsinski A, Tutt CB, Jezek GE, et al. Escherichia coli isolated from a Crohn's disease patient adheres, invades, and induces inflammatory responses in polarized intestinal epithelial cells. Int J Med Microbiol 2008; 298:397-409.
12. Sasaki M, Sitaraman SV, Babbin BA, Gerner-Smidt P, Ribot EM, Garrett N, et al. Invasive Escherichia coli are a feature of Crohn's disease. Lab Invest 2007; 87:1042-54.
13. Boudeau J, Glasser AL, Masseret E, Joly B, Darfeuille-Michaud A. Invasive ability of an Escherichia coli strain isolated from the ileal mucosa of a patient with Crohn's disease. Infect Immun 1999; 67:4499-509.
14. Barnich N, Carvalho FA, Glasser AL, Darcha C, Jantscheff P, Allez M, et al. CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease. J Clin Invest 2007; 117:1566-74.
15. Carvalho FA, Barnich N, Sivignon A, Darcha C, Chan CH, Stanners CP, et al. Crohn's disease adherentinvasive Escherichia coli colonize and induce strong gut inflammation in transgenic mice expressing human CEACAM. J Exp Med 2009; 206:2179-89.
16. Boudeau J, Barnich N, Michaud AD. Type 1 pilimediated adherence of Escherichia coli strain LF82 isolated from Crohn's disease is involved in bacterial invasion of intestinal epithelial cells. Mol Microbiol 2001; 39:1272-84.
17. Ofek I, Hasty DL, Abraham SN, Sharon N. Role of bacterial lectins in urinary tract infections. Molecular mechanisms for diversification of bacterial surface lectins. Adv Exp Med Biol 2000; 485:183-92.
18. Wellens A, Garofalo C, Nguyen H, Van Gerven N, Slättegård R, Hernalsteens JP, et al. Intervening with urinary tract infections using anti-adhesives based on the crystal structure of the FimH-oligomannose-3 complex. PLoS One 2008; 3:2040.
19. Langermann S, Palaszynski S, Barnhart M, Auguste G, Pinkner JS, Burlein J, et al. Prevention of mucosal Escherichia coli infection by FimH-adhesin-based systemic vaccination. Science 1997; 276:607-11.
20. Svensson A, Larsson A, Emtenäs H, Hedenström M, Fex T, Hultgren SJ, et al. Design and evaluation of pilicides: potential novel antibacterial agents directed against uropathogenic Escherichia coli. Chembiochem 2001; 2:915-8.
21. Larsson A, Johansson SM, Pinkner JS, Hultgren SJ, Almqvist F, Kihlberg J, et al. Multivariate design, synthesis and biological evaluation of peptide inhibitors of FimC/FimH protein-protein interactions in uropathogenic Escherichia coli. J Med Chem 2005; 48:935-45.