C-reactive protein levels increase during HIV-1 disease progression in rakai, Uganda, despite the absence of microbial translocation

Journal of Acquired Immune Deficiency Syndromes

Volumn 54, Issue 5, 2010, Pages 556-559

  Redd, Andrew D ^a   Eaton, Kevin P ^b   Kong, Xiangrong ^c   Laeyendecker, Oliver ^a   Lutalo, Tom ^d   Wawer, Maria J ^c   Gray, Ronald H ^c   Serwadda, David ^d,e   Quinn, Thomas C ^a,b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^d RAKAI HEALTH SCIENCES PROGRAM   (Uganda)

^e MAKERERE UNIVERSITY   (Uganda)

Author keywords

Africa; HIV disease progression; immune activation; microbial translocation

Indexed keywords

C REACTIVE PROTEIN;

ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE COURSE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; PRIORITY JOURNAL; UGANDA;

BLOOD CHEMICAL ANALYSIS; C-REACTIVE PROTEIN; DISEASE PROGRESSION; HIV INFECTIONS; HIV-1; HUMANS; LONGITUDINAL STUDIES; UGANDA;

EID: 77955013082     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAI.0b013e3181e0cdea     Document Type: Article

References (12)

1. Bentwich Z, Kalinkovich A, Weisman Z. Immune activation is a dominant factor in the pathogenesis of African AIDS. Immunol Today. 1995;16: 187-191.
2. Rizzardini G, Piconi S, Ruzzante S, et al. Immunological activation markers in the serum of African and European HIV-seropositive and seronegative individuals. AIDS. 1996;10:1535-1542.
3. McCune JM. The dynamics of CD4+ T-cell depletion in HIV disease. Nature. 2001;410:974-979.
4. Douek DC. Disrupting T-cell homeostasis: how HIV-1 infection causes disease. AIDS Rev. 2003;5:172-177.
5. Brenchley JM, Price DA, Schacker TW, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 2006;12:1365-1371.
6. Brenchley JM, Price DA, Douek DC. HIV disease: fallout from a mucosal catastrophe? Nat Immunol. 2006;7:235-239.
7. Redd AD, Dabitao D, Bream JH, et al. Microbial translocation, the innate cytokine response, and HIV-1 disease progression in Africa. Proc Natl Acad Sci USA. 2009;106:6718-6723.
8. Lau B, Sharrett AR, Kingsley LA, et al. C-reactive protein is a marker for human immunodeficiency virus disease progression. Arch Intern Med. 2006;166:64-70.
9. Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest. 2003;111:1805-1812.
10. Zulu I, Hassan G, Njobvu RNL, et al. Cytokine activation is predictive of mortality in Zambian patients with AIDS-related diarrhoea. BMC Infect Dis. 2008;8:156.
11. Melchior JC, Niyongabo T, Henzel D, et al. Malnutrition and wasting, immunodepression, and chronic inflammation as independent predictors of survival in HIV-infected patients. Nutrition. 1999;15:865-869.
12. Drain PK, Kupka R, Msamanga GI, et al. C-reactive protein independently predicts HIV-related outcomes among women and children in a resource-poor setting. AIDS. 2007;21:2067-2075.