Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114 001) to decrease the rate of illness in kids: The DRINK study A patient-oriented, double-blind, cluster-randomized, placebo-controlled, clinical trial

European Journal of Clinical Nutrition

Volumn 64, Issue 7, 2010, Pages 669-677

  Merenstein, D ^a   Murphy, M ^a   Fokar, A ^b   Hernandez, R K ^b   Park, H ^a   Nsouli, H ^b   Sanders, M E ^c   Davis, B A ^d   Niborski, V ^e   Tondu, F ^e   Shara, N M ^b,f  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b MEDSTAR RESEARCH INSTITUTE   (United States)

^c Dairy Food Culture Technologies   (United States)

^d Dannon Company Inc   (United States)

^e DANONE RESEARCH   (France)

^f GEORGETOWN UNIVERSITY   (United States)

Author keywords

clinical trial; functional foods; infections; probiotics

Indexed keywords

PROBIOTIC AGENT;

ARTICLE; CHILD; CHILD NUTRITION; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DAIRY PRODUCT; DISEASE ACTIVITY; DOUBLE BLIND PROCEDURE; DRINKING BEHAVIOR; FEMALE; FERMENTED PRODUCT; FOOD INTAKE; FUNCTIONAL FOOD; GASTROINTESTINAL INFECTION; HUMAN; HUMAN EXPERIMENT; ILLNESS BEHAVIOR; INFECTION PREVENTION; INFECTION RATE; INTERVENTION STUDY; LACTOBACILLUS CASEI; LOWER RESPIRATORY TRACT INFECTION; MALE; NORMAL HUMAN; OUTCOME ASSESSMENT; PATIENT ATTITUDE; PATIENT SAFETY; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; UNITED STATES; UPPER RESPIRATORY TRACT INFECTION;

CHILD; CHILD, PRESCHOOL; COMMUNICABLE DISEASE CONTROL; COMMUNICABLE DISEASES; DAIRY PRODUCTS; DISTRICT OF COLUMBIA; DOUBLE-BLIND METHOD; FEMALE; FERMENTATION; GASTROINTESTINAL DISEASES; HUMANS; INCIDENCE; LACTOBACILLUS CASEI; MALE; PROBIOTICS; RESPIRATORY TRACT INFECTIONS;

LACTOBACILLUS CASEI;

EID: 77955013021     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/ejcn.2010.65     Document Type: Article

References (40)

1. Agarwal KN, Bhasin SK (2002). Feasibility studies to control acute diarrhoea in children by feeding fermented milk preparations Actimel and Indian Dahi. Eur J Clin Nutr 56 (Suppl 4), S56-S59.
2. Baba N, Samson S, Bourdet-Sicard R, Rubio M, Sarfati M (2009). Selected commensal-related bacteria and toll-like receptor 3 agonist combinatorial codes synergistically induce interleukin-12 production by dendritic cells to trigger a T helper type 1 polarizing programme. Immunology 128, e523-e531.
3. Cordell RL, MacDonald JK, Solomon SL, Jackson LA, Boase J (1997). Illnesses and absence due to illness among children attending child care facilities in Seattle-King County, Washington. Pediatrics 100, 850-855.
4. Dales R, Cakmak S, Brand K, Judek S (2004). Respiratory illness in children attending daycare. Pediatric Pulmonology 38, 6409.
5. de Moreno de LeBlanc A, Chaves S, Carmuega E, Weill R, Antoine J, Perdigon G (2008). Effect of long-term continuous consumption of fermented milk containing probiotic bacteria on mucosalimmunity and the activity of peritoneal macrophages. Immunobiology 213, 97-108.
6. Djouzi Z, Andrieux C, Degivry MC, Bouley C, Szylit O (1997). The association of yogurt starters with Lactobacillus casei DN 114.001 in fermented milk alters the composition and metabolism of intestinal microflora in germ-free rats and in human flora- associated rats. J Nutr 127, 2260-2266.
7. Feeney A, North F, Head J, Canner R, Marmot M (1998). Socioeconomic and sex differentials in reason for sickness absence from the Whitehall II Study. Occup Environ Med 55, 91-98.
8. Fleming DW, Cochi SL, Hightower AW, Broome CV (1987). Childhood upper respiratory tract infections: to what degree is incidence affected by day-care attendance? Pediatrics 79, 55-60.
9. Fleming TR, DeMets DL (1996). Surrogate end points in clinical trials: are we being misled? Ann Intern Med 125, 605-613.
10. Food and Agriculture Organization of the United Nations and World Health Organization (2001). Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. Report of a Joint FAO/WHO Expert Consultation on Evaluation of Health and Nutritional Properties of Probiotics in Food Including Powder Milk with Live Lactic Acid Bacteria. Cordoba, Argentina, 1-4 October 2001.
11. Freitas M, Tavan E, Cayuela C, Diop L, Sapin C, Trugnan G (2003). Host-pathogens cross-talk. Indigenous bacteria and probiotics also play the game. Biol Cell 95, 503-506.
12. Giovannini M, Agostoni C, Riva E, Salvini F, Ruscitto A, Zuccotti GV et al. (2007). A randomized prospective double blind controlled trial on effects of long-term consumption of fermented milk containing Lactobacillus casei in pre-school children with allergic asthma and/or rhinitis. Pediatr Res 62, 215-220.
13. Glasgow RE, Magid DJ, Beck A, Ritzwoller D, Estabrooks PA (2005). Practical clinical trials for translating research to practice: design and measurement recommendations. Med Care 43, 551-557.
14. Greenberg SB (2002). Respiratory viral infections in adults. Curr Opin Pulm Med 8, 201-208.
15. Guerin-Danan C, Chabanet C, Pedone C, Popot F, Vaissade P, Bouley C et al. (1998). Milk fermented with yogurt cultures and Lactobacillus casei compared with yogurt and gelled milk: influence on intestinal microflora in healthy infants. Am J Clin Nutr 67, 111-117.
16. Guerin-Danan C, Meslin JC, Chambard A, Charpilienne A, Relano P, Bouley C et al. (2001). Food supplementation with milk fermented by Lactobacillus casei DN-114 001 protects suckling rats from rotavirus-associated diarrhea. J Nutr 131, 111-117.
17. Guillemard E, Tondu F, Lacoin F, Schrezenmeir J (2010). Consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial. Br J Nutr 103, 58-68.
18. Haskins R (1989). Acute illness in day care: how much does it cost? Bull N YAcad Med 65, 319-343.
19. Hatakka K, Savilahti E, Ponka A, Meurman JH, Poussa T, Nase L et al. (2001). Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial. BMJ 322, 1327.
20. Hickson M, D'Souza AL, Muthu N, Rogers TR, Want S, Rajkumar C et al. (2007). Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial. BMJ 335, 80.
21. Ingrassia I, Leplingard A, Darfeuille-Michaud A (2005). Lactobacillus casei DN-114 001 inhibits the ability of adherent-invasive Escherichia coli isolated from Crohn's disease patients to adhere to and to invade intestinal epithelial cells. Appl Environ Microbiol 71, 2880-2887.
22. Kalliomaki M, Salminen S, Arvilommi H, Kero P, Koskinen P, Isolauri E (2001). Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 357, 1076-1079.
23. Lin HC, Su BH, Chen AC, Lin TW, Tsai CH, Yeh TF et al. (2005). Oral probiotics reduce the incidence and severity of necrotizingenterocolitis in very low birth weight infants. Pediatrics 115, 1-4.
24. Lin JS, Chiu YH, Lin NT, Chu CH, Huang KC, Liao KW et al. (2009). Different effects of probiotic species/strains on infections in preschool children: a double-blind, randomized, controlled study. Vaccine 27, 1073-1079.
25. Mastrandrea F, Coradduzza G, Serio G, Minardi A, Manelli M, Ardito S et al. (2004). Probiotics reduce the CD34 + hemopoietic precursor cell increased traffic in allergic subjects. Allerg Immunol (Paris) 36, 118-122.
26. Medici M, Vinderola CG, Weill R, Perdigon G (2005). Effect of fermented milk containing probiotic bacteria in the prevention of an enter- oinvasive Escherichia coli infection in mice. J Dairy Res 72, 243-249.
27. Oozeer R, Goupil-Feuillerat N, Alpert CA, van de Guchte M, Anba J, Mengaud J et al. (2002). Lactobacillus casei is able to survive and initiate protein synthesis during its transit in the digestive tract of human flora-associated mice. Appl Environ Microbiol 68, 3570-3574.
28. Oozeer R, Leplingard A, Mater DD, Mogenet A, Michelin R, Seksek I et al. (2006). Survival of Lactobacillus casei in the human digestive tract after consumption of fermented milk. Appl Environ Microbiol 72, 5615-5617.
29. Parassol N, Freitas M, Thoreux K, Dalmasso G, Bourdet-Sicard R, Rampal P (2005). Lactobacillus casei DN-114 001 inhibits the increase in paracellular permeability of enteropathogenic Escher- ichia coli-infected T84 cells. Res Microbiol 156, 256-262.
30. Pedone CA, Bernabeu AO, Postaire ER, Bouley CF, Reinert P (1999). The effect of supplementation with milk fermented by Lactoba- cillus casei (strain DN-114 001) on acute diarrhoea in children attending day care centres. Int J Clin Pract 53, 179-184.
31. Pedone CA, Arnaud CC, Postaire ER, Bouley CF, Reinert P (2000). Multicentric study of the effect of milk fermented by Lactobacillus casei on the incidence of diarrhoea. Int J Clin Pract 54, 568-571.
32. Rochet V, Rigottier-Gois L, Levenez F, Cadiou J, Marteau P, Bresson JL et al. (2008). Modulation of Lactobacillus casei in ileal and fecal samples from healthy volunteers after consumption of a fermented milk containing Lactobacillus casei DN-114 001Rif. Can J Microbiol 54, 660-667.
33. Rosenfeldt V, Michaelsen KF, Jakobsen M, Larsen CN, Moller PL, Tvede M et al. (2002). Effect of probiotic Lactobacillus strains on acute diarrhea in a cohort of nonhospitalized children attending day-care centers. Pediatr Infect Dis J 21, 417-419.
34. Shaughnessy AF, Slawson DC (1997). POEMs: patient-oriented evidence that matters. Ann Intern Med 126, 667.
35. Shaughnessy AF, Slawson DC (2003). What happened to the valid POEMs? A survey of review articles on the treatment of type 2 diabetes. BMJ 327, 266.
36. Silverstein M, Sales AE, Koepsell TD (2003). Health care utilization and expenditures associated with child care attendance: a nationally representative sample. Pediatrics 111, e371-e375.
37. Tien MT, Girardin SE, Regnault B, Le Bourhis L, Dillies MA, Coppee JY et al. (2006). Anti-inflammatory effect of Lactobacillus casei on Shigella-infected human intestinal epithelial cells. J Immunol 176, 1228-1237.
38. Tunis SR, Stryer DB, Clancy CM (2003). Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy. JAMA 290, 1624-1632.
39. Vanderhoof JA, Whitney DB, Antonson DL, Hanner TL, Lupo JV, Young RJ (1999). Lactobacillus GG in the prevention of antibiotic- associated diarrhea in children. J Pediatr 135, 564-568.
40. Weizman Z, Asli G, Alsheikh A (2005). Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic agents. Pediatrics 115, 5-9.