Apple, cherry, and blackcurrant increases nuclear factor kappa B activation in liver of transgenic mice

Nutrition and Cancer

Volumn 62, Issue 6, 2010, Pages 841-848

  Balstad, Trude R ^a   Paur, Ingvild ^a   Poulsen, Morten ^b   Markowski, Jaroslaw ^c   Kolodziejczyk, Krzysztof ^d   Dragsted, Lars O ^e   Myhrstad, Mari C W ^f   Blomhoff, Rune ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c RESEARCH INSTITUTE OF POMOLOGY AND FLORICULTURE   (Poland)

^d LODZ UNIVERSITY OF TECHNOLOGY   (Poland)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

^f OSLO METROPOLITAN UNIVERSITY   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; LUCIFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APPLE; ARTICLE; BLACK CURRANT; CHERRY; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME ACTIVATION; ENZYME ACTIVITY; EX VIVO STUDY; FRUIT; IN VIVO STUDY; INFLAMMATION; LIVER; MOLECULAR IMAGING; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ALANINE TRANSAMINASE; ANIMAL FEED; ANIMALS; LIVER; MALE; MALUS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NF-KAPPA B; PRUNUS; RIBES;

MALUS X DOMESTICA; MUS; MUS MUSCULUS;

EID: 77955004113     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1080/01635581003695749     Document Type: Article

References (38)

1. Karin M, Yamamoto Y, and Wang QM: The IKK NF-kappaB system: a treasure trove for drug development. Nat Rev Drug Discov 3, 17-26, 2004.
2. Valen G, Yan ZQ, and Hansson GK: Nuclear factor kappa-B and the heart. J Am Coll Cardiol 38, 307-314, 2001.
3. Mattson MP and Camandola S: NF-kappaB in neuronal plasticity and neurodegenerative disorders. J Clin Invest 107, 247-254, 2001.
4. Feldmann M, Andreakos E, Smith C, Bondeson J, Yoshimura S, et al.: Is NF-kappaB a useful therapeutic target in rheumatoid arthritis? Ann Rheum Dis 61(2 Suppl.), ii13-ii18, 2002.
5. Christman JW, Sadikot RT, and Blackwell TS: The role of nuclear factor- kappa B in pulmonary diseases. Chest 117, 1482-1487, 2000.
6. Neurath MF, Becker C, and Barbulescu K: Role of NF-kappaB in immune and inflammatory responses in the gut. Gut 43, 856-860, 1998.
7. Karin M, Cao Y, Greten FR, and Li ZW: NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2, 301-310, 2002.
8. Greten FR and Karin M: The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer. Cancer Lett 206, 193-199, 2004.
9. Luo JL, Maeda S, Hsu LC, Yagita H, and Karin M: Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression. Cancer Cell 6, 297-305, 2004.
10. Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, et al.: NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 431, 461-466, 2004.
11. Chen LF and Greene WC: Shaping the nuclear action of NF-kappaB. Nat Rev Mol Cell Biol 5, 392-401, 2004.
12. Pahl HL: Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18, 6853-6866, 1999.
13. Karin M and Greten FR: NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5, 749-759, 2005.
14. World Cancer Research Fund/American Institute for Cancer Research: Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective. Washington, DC: American Institute for Cancer Research, 2007.
15. FAO/WHO. Joint FAO/WHO Expert Report on Diet, Nutrition, and the Prevention of Chronic Disease. WHO Technical Report 916, 2003.
16. Halvorsen BL, Holte K, Myhrstad MC, Barikmo I, Hvattum E, et al.: A systematic screening of total antioxidants in dietary plants. J Nutr 132, 461-471, 2002.
17. Halvorsen BL, Carlsen MH, Phillips KM, Bohn SK, Holte K, et al.: Content of redox-active compounds (i.e., antioxidants) in foods consumed in the United States. Am J Clin Nutr 84, 95-135, 2006.
18. Boyer J and Liu RH: Apple phytochemicals and their health benefits. Nutr J 3, 5-20, 2004.
19. Surh YJ and Na HK: NF-kappaB and Nrf2 as prime molecular targets for chemoprevention and cytoprotection with anti-inflammatory and antioxidant phytochemicals. Genes Nutr 2, 313-317, 2008.
20. Carlsen H, Moskaug JO, Fromm SH, and Blomhoff R: In vivo imaging of NF-kappa B activity. J Immunol 168, 1441-1446, 2002.
21. Benzie IF and Strain JJ: The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem 239, 70-76, 1996.
22. Singleton VL and Rossi JA Jr.: Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Vitic 16, 144-158, 1965.
23. ChatterjeeS, Premachandran S, Shukla J, andPoduval TB: Synergistic therapeutic potential of dexamethasone and L-arginine in lipopolysaccharide- induced septic shock. J Surg Res 140, 99-108, 2007.
24. Reeves PG: Components of the AIN-93 diets as improvements in the AIN- 76A diet. J Nutr 127, 838S-841S, 1997.
25. Lotito SB and Frei B: The increase in human plasma antioxidant capacity after apple consumption is due to the metabolic effect of fructose on urate, not apple-derived antioxidant flavonoids. Free Radic Biol Med 37,251-258, 2004.
26. Strazzullo P and Puig JG: Uric acid and oxidative stress: relative impact on cardiovascular risk? Nutr Metab Cardiovasc Dis 17, 409-414, 2007.
27. Le KA and Bortolotti M: Role of dietary carbohydrates and macronutrients in the pathogenesis of nonalcoholic fatty liver disease. Curr Opin Clin Nutr Metab Care 11, 477-482, 2008.
28. Roglans N, Vila L, Farre M, Alegret M, Sanchez RM, et al.: Impairment of hepatic Stat-3 activation and reduction of PPARalpha activity in fructose- fed rats. Hepatology 45, 778-788, 2007.
29. Rutledge AC and Adeli K: Fructose and the metabolic syndrome: pathophysiology and molecular mechanisms. Nutr Rev 65, S13-S23, 2007.
30. Paur I, Austenaa LM, and Blomhoff R: Extracts of dietary plants are efficient modulators of nuclear factor kappa B. Food Chem Toxicol 46, 1288-1297, 2008.
31. Dinkova-Kostova AT and Talalay P: Direct and indirect antioxidant properties of inducers of cytoprotective proteins. Mol Nutr Food Res 52(1 Suppl.), S128-S138, 2008.
32. Neyrinck AM, Mouson A, and Delzenne NM: Dietary supplementation with laminarin, a fermentable marine beta (1-3) glucan, protects against hepatotoxicity induced by LPS in rat by modulating immune response in the hepatic tissue. Int Immunopharmacol 7, 1497-1506, 2007.
33. Maeda S, Kamata H, Luo JL, Leffert H, and Karin M: IKKbeta couples hep- atocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121, 977-990, 2005.
34. Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, et al.: IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118, 285-296, 2004.
35. Yang RC, Chen HW, Lu TS, and Hsu C: Potential protective effect of NF-kappaB activity on the polymicrobial sepsis of rats preconditioning heat shock treatment. Clin Chim Acta 302, 11-22, 2000.
36. Teoh N, Dela PA, and Farrell G: Hepatic ischemic preconditioning in mice is associated with activation of NF-kappaB, p38 kinase, and cell cycle entry. Hepatology 36, 94-102, 2002.
37. Ricciardi R, Shah SA, Wheeler SM, Quarfordt SH, Callery MP, et al.: Regulation of NFkappaB in hepatic ischemic preconditioning. J Am Coll Surg 195, 319-326, 2002.
38. Eliseev RA, Vanwinkle B, Rosier RN, and Gunter TE: Diazoxide-mediated preconditioning against apoptosis involves activation of cAMP-response element-binding protein (CREB) and NFkappaB. J Biol Chem 279, 46748-46754, 2004.