Treatment with fall-risk-increasing and fracture-preventing drugs before and after a hip fracture: An observational study

Drugs and Aging

Volumn 27, Issue 8, 2010, Pages 653-661

  Sj̈berg, Christina ^a   Bladh, Lina ^a   Klintberg, Lars ^a   Mellstrm, Dan ^a   Ohlsson, Claes ^a   Wallerstedt, Susanna M ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Elderly; Hip fracture; Osteoporosis

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; CALCIUM; SELECTIVE ESTROGEN RECEPTOR MODULATOR; VITAMIN D;

AGED; ARTICLE; BONE DENSITOMETRY; DUAL ENERGY X RAY ABSORPTIOMETRY; FALLING; FEMALE; HIP FRACTURE; HOSPITAL ADMISSION; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; SWEDEN; UNIVERSITY HOSPITAL; ADVERSE DRUG REACTION; CHEMICALLY INDUCED; DRUG THERAPY; HIP FRACTURES; RISK; STATISTICS AND NUMERICAL DATA; VERY ELDERLY;

ACCIDENTAL FALLS; AGED; AGED, 80 AND OVER; CALCIUM; DIPHOSPHONATES; DRUG THERAPY; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; FEMALE; HIP FRACTURES; HUMANS; MALE; RISK; SELECTIVE ESTROGEN RECEPTOR MODULATORS; SWEDEN; VITAMIN D;

EID: 77955000110     PISSN: 1170229X     EISSN: 11791969     Source Type: Journal    
DOI: 10.2165/11538200-000000000-00000     Document Type: Article

References (46)

1. Johnell O, Gullberg B, Allander E, et al. The apparent incidence of hip fracture in Europe: a study of national register sources. MEDOS Study Group. Osteoporos Int 1992 Nov; 2 (6): 298-302
2. Kanis JA, Johnell O, Oden A, et al. Long-term risk of osteoporotic fracture in Malmo. Osteoporos Int 2000; 11 (8): 669-674
3. Hasserius R, Johnell O, Nilsson BE, et al. Hip fracture patients have more vertebral deformities than subjects in population-based studies. Bone 2003 Feb; 32 (2): 180-184
4. Colon-Emeric C, Kuchibhatla M, Pieper C, et al. The contribution of hip fracture to risk of subsequent fractures: data from two longitudinal studies. Osteoporos Int 2003 Nov; 14 (11): 879-883
5. Kanis JA, Oden A, Johnell O, et al. The components of excess mortality after hip fracture. Bone 2003 May; 32 (5): 468-473
6. Sernbo I, Johnell O. Consequences of a hip fracture: a prospective study over 1 year. Osteoporos Int 1993 May; 3 (3): 148-153
7. Meyer HE, Tverdal A, Selmer R. Weight variability, weight change and the incidence of hip fracture: a prospective study of 39,000 middle-aged Norwegians. Osteoporos Int 1998; 8 (4): 373-378
8. Nguyen T, Sambrook P, Kelly P, et al. Prediction of osteoporotic fractures by postural instability and bone density. BMJ 1993 Oct 30; 307 (6912): 1111-1115
9. Kanis JA, Borgstrom F, De Laet C, et al. Assessment of fracture risk. Osteoporos Int 2005 Jun; 16 (6): 581-589
10. Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet 2002 May 18; 359 (9319): 1761-1767
11. Gillespie LD, Gillespie WJ, Robertson MC, et al. Interventions for preventing falls in elderly people. Cochrane Database Syst Rev 2003; (4): CD000340
12. Speechley M, Tinetti M. Falls and injuries in frail and vigorous community elderly persons. J Am Geriatr Soc 1991 Jan; 39 (1): 46-52
13. Kallin K. Falls in older people in geriatric care settings. Umeai: Umeai University, 2004
14. Kallin K, Lundin-Olsson L, Jensen J, et al. Predisposing and precipitating factors for falls among older people in residential care. Public Health 2002 Sep; 116 (5): 263-271
15. Tangman S, Eriksson S, Gustafson Y, et al. Precipitating factors for falls among patients with dementia on a psychogeriatric ward. Int Psychogeriatr 2010 Feb; 2: 1-9
16. Van Der Velde N, Stricker BH, Pols HA, et al. Risk of falls after withdrawal of fall-risk-increasing drugs: a prospective cohort study. Br J Clin Pharmacol 2007 Feb; 63 (2): 232-237
17. Leipzig RM, Cumming RG, Tinetti ME. Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs. J Am Geriatr Soc 1999 Jan; 47 (1): 30-39
18. Leipzig RM, Cumming RG, Tinetti ME. Drugs and falls in older people: a systematic review and meta-analysis: II. Cardiac and analgesic drugs. J Am Geriatr Soc 1999 Jan; 47 (1): 40-50
19. Kanis JA. Diagnosis of osteoporosis and assessment of fracture risk. Lancet 2002 Jun 1; 359 (9321): 1929-1936
20. Melton 3rd LJ. The prevalence of osteoporosis: gender and racial comparison. Calcif Tissue Int 2001 Oct; 69 (4): 179-181
21. Johnell O, Kanis JA, Oden A, et al. Predictive value of BMD for hip and other fractures. J Bone Miner Res 2005 Jul; 20 (7): 1185-1194
22. Sowers MR, Clark MK, Jannausch ML, et al. Body size, estrogen use and thiazide diuretic use affect 5-year radial bone loss in postmenopausal women. Osteoporos Int 1993 Dec; 3 (6): 314-321
23. Diem SJ, Blackwell TL, Stone KL, et al. Use of antidepressants and rates of hip bone loss in older women: the study of osteoporotic fractures. Arch Intern Med 2007 Jun 25; 167 (12): 1240-1245
24. Berthold HK, Unverdorben S, Zittermann A, et al. Agedependent effects of atorvastatin on biochemical bone turnover markers: a randomized controlled trial in postmenopausal women. Osteoporos Int 2004 Jun; 15 (6): 459-467
25. Panneman MJ, Lips P, Sen SS, et al. Undertreatment with anti-osteoporotic drugs after hospitalization for fracture. Osteoporos Int 2004 Feb; 15 (2): 120-124
26. Kanis JA, on behalf of the World Health Organization Scientific Group (2007). Assessment of osteoporosis at the primary health-care level. Technical report. Sheffield: World Health Organization Collaborating Centre for Metabolic Bone Diseases, University of Sheffield, 2007
27. QaseemA, Snow V, Shekelle P, et al. Pharmacologic treatment of low bone density or osteoporosis to prevent fractures: a clinical practice guideline from the American College of Physicians. Ann Intern Med 2008 Sep 16; 149 (6): 404-415
28. Albertsson DM, Mellstrom D, Petersson C, et al. Validation of a 4-item score predicting hip fracture and mortality risk among elderly women. Ann FamMed 2007 Jan-Feb; 5 (1): 48-56
29. The Swedish Medical Products Agency. Treatment of osteoporosis: treatment guidelines. Information frain Laikemedelsverket 2007; 18 (4): 19-29
30. Campbell AJ, Robertson MC, Gardner MM, et al. Psychotropic medication withdrawal and a home-based exercise program to prevent falls: a randomized, controlled trial. J Am Geriatr Soc 1999 Jul; 47 (7): 850-853
31. Lee JS, Kwok T, Leung PC, et al. Medical illnesses are more important than medications as risk factors of falls in older community dwellers? A cross-sectional study. Age Ageing 2006 May; 35 (3): 246-251
32. Iyer S, Naganathan V, McLachlan AJ, et al. Medication withdrawal trials in people aged 65 years and older: a systematic review. Drugs Aging 2008; 25 (12): 1021-1031
33. Myers MG, Weingert ME, Fisher RH, et al. Unnecessary diuretic therapy in the elderly. Age Ageing 1982 Nov; 11 (4): 213-221
34. Nelson MR, Reid CM, Krum H, et al. Predictors of normotension on withdrawal of antihypertensive drugs in elderly patients: prospective study in second Australian national blood pressure study cohort. BMJ 2002 Oct 12; 325 (7368): 815-819
35. Curran HV, Collins R, Fletcher S, et al. Older adults and withdrawal from benzodiazepine hypnotics in general practice: effects on cognitive function, sleep, mood and quality of life. Psychol Med 2003 Oct; 33 (7): 1223-1237
36. Lakatos P. Thyroid hormones: beneficial or deleterious for bone? Calcif Tissue Int 2003 Sep; 73 (3): 205-209
37. Barrett-Connor E, Weiss TW, McHorney CA, et al. Predictors of falls among postmenopausal women: results from the National Osteoporosis Risk Assessment (NORA). Osteoporos Int 2009 May; 20 (5): 715-722
38. Kallin K, Gustafson Y, Sandman PO, et al. Drugs and falls in older people in geriatric care settings. Aging Clin Exp Res 2004 Aug; 16 (4): 270-276
39. Boonen S, Dejaeger E, Vanderschueren D, et al. Osteoporosis and osteoporotic fracture occurrence and prevention in the elderly: a geriatric perspective. Best Pract Res Clin Endocrinol Metab 2008 Oct; 22 (5): 765-785
40. Ensrud KE, Black DM, Palermo L, et al. Treatment with alendronate prevents fractures in women at highest risk: results from the Fracture Intervention Trial. Arch Intern Med 1997 Dec 8-22; 157 (22): 2617-2624
41. Boonen S,McClung MR, Eastell R, et al. Safety and efficacy of risedronate in reducing fracture risk in osteoporotic women aged 80 and older: implications for the use of antiresorptive agents in the old and oldest old. J Am Geriatr Soc 2004 Nov; 52 (11): 1832-1839
42. Tosi LL, Lane JM. Osteoporosis prevention and the orthopaedic surgeon: when fracture care is not enough. J Bone Joint Surg Am 1998 Nov; 80 (11): 1567-1569
43. Rabenda V, Vanoverloop J, Fabri V, et al. Low incidence of anti-osteoporosis treatment after hip fracture. J Bone Joint Surg Am 2008 Oct; 90 (10): 2142-2148
44. Juby AG, De Geus-Wenceslau CM. Evaluation of osteoporosis treatment in seniors after hip fracture. Osteoporos Int 2002 Mar; 13 (3): 205-210
45. Lyles KW, Colon-Emeric CS, Magaziner JS, et al. Zoledronic acid and clinical fractures and mortality after hip fracture. N Engl J Med 2007 Nov 1; 357 (18): 1799-1809
46. Mancia G, De Backer G, Dominiczak A, et al. Guidelines for the Management of Arterial Hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007 Jun; 25 (6): 1105-1187 (Pubitemid 46924065)