Administration of a low dose of sildenafil for 1 week decreases intrahepatic resistance in rats with biliary cirrhosis: The role of NO bioavailability

Clinical Science

Volumn 119, Issue 1, 2010, Pages 45-55

  Lee, Kuei Chuan ^a,b   Yang, Ying Ying ^a,b   Huang, Yi Tsau ^b   Lee, Fa Yauh ^a,b   Hou, Ming Chih ^a,b   Lin, Han Chieh ^a,b   Lee, Shou Dong ^a,b  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Cirrhosis; Intrahepatic resistance; Microcirculation; Nitric oxide; Phosphodiesterase inhibitor; Tetrahydrobiopterin (BH4)

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; GUANYLATE CYCLASE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PHOSPHODIESTERASE V; SILDENAFIL; TETRAHYDROBIOPTERIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE DUCT LIGATION; BILIARY CIRRHOSIS; BIOAVAILABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVITY; FLUORESCENCE MICROSCOPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER PERFUSION; LIVER SINUSOID; LOW DRUG DOSE; MALE; MICROCIRCULATION; MICROVASCULATURE; NONHUMAN; PORTAL VEIN BLOOD PRESSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION; WESTERN BLOTTING;

ANIMALS; BIOLOGICAL AVAILABILITY; DRUG ADMINISTRATION SCHEDULE; DRUG EVALUATION, PRECLINICAL; HEMODYNAMICS; HYPERTENSION, PORTAL; LIVER CIRCULATION; LIVER CIRRHOSIS, BILIARY; MALE; NITRIC OXIDE; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PORTAL PRESSURE; PURINES; RATS; RATS, SPRAGUE-DAWLEY; SULFONES; VASCULAR RESISTANCE;

EID: 77954950163     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20090601     Document Type: Article

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