Inhibition of thrombin formation by active site mutated (S360A) activated protein C

Journal of Biological Chemistry

Volumn 285, Issue 30, 2010, Pages 22890-22900

  Nicolaes, Gerry A F ^a   Bock, Paul E ^b   Segers, Kenneth ^a   Wildhagen, Karin C A A ^a   Dahlbäck, Björn ^c   Rosing, Jan ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; ACTIVE SITE; ANTICOAGULANT ACTIVITIES; CLEAVAGE SITES; COAGULATION FACTOR; COFACTORS; EXOSITE INTERACTIONS; FACTOR VIIIA; IN-VIVO; MICHAELIS COMPLEX; MODEL SYSTEM; PROTEOLYTIC ACTIVITIES; SUBSTRATE RECOGNITION;

COAGULATION; ENZYME ACTIVITY; GLYCOPROTEINS; SUBSTRATES;

PROTEINS;

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5A; BLOOD CLOTTING FACTOR 8A; BLOOD CLOTTING FACTOR 9; PROTEIN S; PROTHROMBIN; THROMBIN;

ANTICOAGULATION; ARTICLE; BINDING COMPETITION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DOWN REGULATION; ENZYME ACTIVE SITE; HUMAN; MOLECULAR DOCKING; MOLECULAR MODEL; MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY;

ARGININE; BINDING, COMPETITIVE; BLOOD COAGULATION; BLOOD COAGULATION FACTORS; CATALYTIC DOMAIN; CELL LINE; CYSTEINE ENDOPEPTIDASES; ENZYME ACTIVATION; HUMANS; MODELS, MOLECULAR; MUTATION; NEOPLASM PROTEINS; PROTEIN C; PROTEIN S; PROTEIN STABILITY; RECOMBINANT PROTEINS; THROMBIN;

EID: 77954943563     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.131029     Document Type: Article

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