High-grade astrocytomas show increased nestin and Wilmss Tumor Gene (WT1) protein expression

International Journal of Surgical Pathology

Volumn 18, Issue 4, 2010, Pages 255-259

  Rushing, Elisabeth J ^a   Sandberg, Glenn D ^a   Horkayne Szakaly, Iren ^a  

^a ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

Author keywords

glioma; immunohistochemistry; nestin; tissue microarray; WT1 protein

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; KI 67 ANTIGEN; NESTIN; NEURON SPECIFIC NUCLEAR PROTEIN; PROTEIN P53; WT1 PROTEIN; INTERMEDIATE FILAMENT PROTEIN; NERVE PROTEIN; NES PROTEIN, HUMAN; TUMOR MARKER;

ADOLESCENT; ADULT; AGED; ARTICLE; ASTROCYTOMA; CANCER GROWTH; CARCINOGENESIS; CHILD; CLINICAL ARTICLE; FEMALE; GENE; HUMAN; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; WT1 GENE; BRAIN TUMOR; IMMUNOHISTOCHEMISTRY; INFANT; METABOLISM; MIDDLE AGED; PATHOLOGY; PRESCHOOL CHILD; TISSUE MICROARRAY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ASTROCYTOMA; BRAIN NEOPLASMS; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; INTERMEDIATE FILAMENT PROTEINS; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; NESTIN; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL; WT1 PROTEINS; YOUNG ADULT;

EID: 77954931460     PISSN: 10668969     EISSN: 19402465     Source Type: Journal    
DOI: 10.1177/1066896909338596     Document Type: Article

References (25)

1. Nakatsuka S., Oji Y., Horiuchi T., et al. Immunohistochemical detection of WT1 protein in a variety of cancer cells. Mod Pathol. 2006 ; 19: 804-814.
2. Oka Y., Tsuboi A., Oji Y., Kawase I., Sugiyama H. WT1 peptide vaccine for the treatment of cancer. Curr Opin Immunol. 2008 ; 20: 211-220.
3. Kerst G., Bergold N., Gieseke F., et al. WT1 protein expression in childhood acute leukemia. Am J Hematol. 2008 ; 83: 382-386.
4. Schittenhelm J., Beschorner R., Simon P., et al. Diagnostic value of WT1 in neuroepithelial tumours. Neuropathol Appl Neurobiol. 2009 ; 35: 69-81.
5. Schittenhelm J., Mittelbronn M., Nguyen TD, Meyermann R., Beschorner R. WT1 expression distinguishes astrocytic tumor cells from normal and reactive astrocytes. Brain Pathol. 2008 ; 18: 344-353.
6. Hashiba T., Izumoto S., Kagawa N., et al. Expression of WT1 protein and correlation with cellular proliferation in glial tumors. Neurol Med Chir (Tokyo). 2007 ; 47: 165-170.
7. Tohyama T., Lee VMY, Rorke LB, Marvin M., McKay RDG, Trojanowski JO Nestin expression in embryonic human neuroepithelium and in human neuroepithelial tumor cells. Lab Invest. 1992 ; 66: 303-313.
8. Almqvist PM, Mah R., Lendahl U., Jacobsson B., Hendson G. Immunohistochemical detection of nestin in pediatric brain tumors. J Histochem. 2002 ; 50: 147-158.
9. Kanamori M., Kawaguchi T., Nigro JM, et al. Contribution of Notch signaling activation to human glioblastoma multiforme. J Neurosurg. 2007 ; 106: 417-427.
10. Shih AH, Holland EC Notch signaling enhances nestin expression in gliomas. Neoplasia. 2006 ; 8: 1072-1082.
11. Wagner N., Wagner KD, Scholz H., Kirschner KM, Schedl A. Intermediate filament protein nestin is expressed in the developing kidney and heart and might be regulated by the Wilms tumor suppressor Wt1. Am J Physiol Regul Integr Comp Physiol. 2006 ; 291: R779 - R787.
12. Bieberich E., MacKinnon S., Silva J., Noggle S., Condie BG Regulation of cell death in mitotic neural progenitor cells by asymmetric distribution of prostate apoptosis response 4 (PAR-4) and simultaneous elevation of endogenous ceramide. J Cell Biol. 2003 ; 162: 469-479.
13. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, eds. World Health Organization Classification of Tumours of the Central Nervous System. 4 th ed. Lyon, France: IARC Press ; 2007.
14. Niksic M., Slight J., Sanford JR, Caceres JF, Hastie ND The Wilms tumor protein (WT1) shuttles between nucleus and cytoplasm and is present in functional polysomes. Hum Mol Genet. 2004 ; 13: 463-471.
15. Nakahara Y., Okamoto H., Mineta T., Tabuchi K. Expression of the Wilms tumor gene product WT1 in glioblastomas and medulloblastomas. Brain Tumor Pathol. 2004 ; 21: 113-116.
16. Wagner N., Michiels JF, Schedl A., Wagner KD The Wilms tumour suppressor WT1 is involved in endothelial cell proliferation and migration: expression in tumour vessels in vivo. Oncogene. 2008 ; 27: 3662-3672.
17. Sanai N., Alvarez-Buylla A., Berger MS Neural stem cells and the origin of glioas. N Engl J Med. 2005 ; 353: 811-822.
18. Singh SK, Clarke ID, Terasaki M., et al. Identification of a cancer stem cell in human brain tumors. Cancer Res. 2003 ; 63: 5821-5828.
19. Yuan X., Curtin J., Xiong Y., et al. Isolation of cancer stem cells from adult glioblastoma multiforme. Oncogene. 2004 ; 23: 9392-9400.
20. Galli R., Binda E., Orfanelli U., et al. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res. 2004 ; 64: 7011-7021.
21. Bao S., Wu Q., McLendon RE, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006 ; 444: 756-760.
22. Bao S., Wu Q., Sathornsumetee S., et al. Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res. 2006 ; 66: 7843-7848.
23. Liu G., Yuan X., Zeng Z., et al. Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer. 2006 ; 5: 67.
24. Hambardzumyan D., Becher OJ, Holland EC Cancer stem cells and survival pathways. Cell Cycle. 2008 ; 7: 1371-1378.
25. Hambardzumyan D., Becher OJ, Rosenblum MK, Pandolfi PP, Manova-Todorova K., Holland EC PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo. Genes Dev. 2008 ; 22: 436-448.