Combined-modality treatment for anal cancer: Current strategies and future directions

Strahlentherapie und Onkologie

Volumn 186, Issue 7, 2010, Pages 361-366

  Fraunholz, Ingeborg ^b   Rabeneck, Daniela ^b   Weiß, Christian ^b   Rödel, Claus ^a  

^a GOETHE UNIVERSITY   (Germany)

^b NONE

Author keywords

Anal cancer; Chemoradiotherapy; Cisplatin; Induction chemotherapy; Maintenance chemotherapy

Indexed keywords

ANTINEOPLASTIC AGENT; CAPECITABINE; CETUXIMAB; CISPLATIN; FLUOROURACIL; MITOMYCIN C; OXALIPLATIN; MITOMYCIN;

ANUS CANCER; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL TRIAL; DRUG DOSE REGIMEN; DRUG RESPONSE; HUMAN; MAINTENANCE THERAPY; MULTIMODALITY CANCER THERAPY; OUTCOME ASSESSMENT; PATIENT COMPLIANCE; RADIATION DOSE DISTRIBUTION; REVIEW; ADJUVANT CHEMOTHERAPY; ADJUVANT THERAPY; ANUS TUMOR; PATIENT CARE; RADIATION DOSE FRACTIONATION; RADIATION RESPONSE; RANDOMIZED CONTROLLED TRIAL;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ANUS NEOPLASMS; CHEMOTHERAPY, ADJUVANT; CISPLATIN; COMBINED MODALITY THERAPY; DOSE FRACTIONATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; FLUOROURACIL; HUMANS; MITOMYCIN; NEOADJUVANT THERAPY; PATIENT CARE TEAM; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 77954930820     PISSN: 01797158     EISSN: 1439099X     Source Type: Journal    
DOI: 10.1007/s00066-010-2162-x     Document Type: Review

References (31)

1. J.A. Ajani K.A. Winter L.L. Gunderson 2008 Fluorouracil, mitomycin, and radiotherapy vs. fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial JAMA 299 1914 21 10.1001/jama.299.16. 1914 1:CAS:528:DC%2BD1cXltFWgsLs%3D (Pubitemid 351574921)
2. A. Allal J.M. Kurtz G. Pipard 1993 Chemoradiotherapy versus radiotherapy alone for anal cancer: a retrospective comparison Int J Radiat Oncol Biol Phys 27 59 66 1:STN:280:DyaK3sznsVKmsQ%3D%3D
3. G. Alvarez A. Perry B.R. Tan 2006 Expression of epidermal growth factor receptor in squamous cell carcinomas of the anal canal is independent of gene amplification Mod Pathol 19 942 9 10.1038/modpathol.3800608 1:CAS:528: DC%2BD28Xls1KitLw%3D
4. H. Bartelink F. Roelofsen F. Eschwege 1997 Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups J Clin Oncol 15 2040 9 1:CAS:528: DyaK2sXjsVCrt7k%3D
5. J.F. Bosset F. Roelofsen D.A. Morgan 2003 Shortened irradiation scheme, continuous infusion of 5-fluorouracil and fractionation of mitomycin C in locally advanced anal carcinomas. Results of a phase II study of the European Organization for Research and Treatment of Cancer. Radiotherapy and Gastrointestinal Cooperative Groups Eur J Cancer 39 45 51 10.1016/S0959-8049(02) 00377-5 1:CAS:528:DC%2BD38Xps12msLw%3D (Pubitemid 36005424)
6. Conroy T, Ducreux M, Lemanski C, et al. Treatment intensification by induction chemotherapy (ICT) and radiation dose escalation in locally advanced squamous cell anal canal carcinoma (LAAC): definitive analysis of the intergroup ACCORD 03 trial. J Clin Oncol 2009;27:Suppl:abstract 4033.
7. G. Crehange M. Bosset F. Lorchel 2007 Combining cisplatin and mitomycin with radiotherapy in anal carcinoma Dis Colon Rectum 50 43 9 10.1007/s10350-006-0761-5
8. R. Doci R. Zucali G. La Monica 1996 Primary chemoradiation therapy with fluorouracil and cisplatin for cancer of the anus: results in 35 consecutive patients J Clin Oncol 14 3121 5 1:CAS:528:DyaK2sXitl2itg%3D%3D
9. Eng C, Chang GJ, Das P, et al. Phase II study of capecitabine and oxaliplatin with concurrent radiation therapy (XELOX-XRT) for squamous cell carcinoma of the anal canal. J Clin Oncol 2009;27:Suppl:abstract 4116.
10. Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin. UKCCCR Anal Cancer Trial Working Party. UK Co-ordinating Committee on Cancer Research. Lancet 1996;348:1049-54.
11. M. Flam M. John T.F. Pajak 1996 Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study J Clin Oncol 14 2527 39 1:CAS:528:DyaK28XlvVGisr0%3D
12. R. Glynne-Jones H. Meadows S. Wan 2008 EXTRA - a multicenter phase II study of chemoradiation using a 5 day per week oral regimen of capecitabine and intravenous mitomycin C in anal cancer Int J Radiat Oncol Biol Phys 72 119 26 1:CAS:528:DC%2BD1cXhtVamu77E
13. A. Hung C. Crane M. Delclos 2003 Cisplatin-based combined modality therapy for anal carcinoma: a wider therapeutic index Cancer 97 1195 202 10.1002/cncr.11161 1:CAS:528:DC%2BD3sXisVKhtbs%3D (Pubitemid 36237304)
14. James R, Wan S, Glynne-Jones R, et al. A randomized trial of chemoradiation using mitomycin or cisplatin, with or without maintenance cisplatin/ 5FU in squamous cell carcinoma of the anus (ACT II). J Clin Oncol 2009;27:Suppl:abstract 4009.
15. L.H. Le R. Chetty M.J. Moore 2005 Epidermal growth factor receptor expression in anal canal carcinoma Am J Clin Pathol 124 20 3 10.1309/X4UADHVN317V2XMW 1:CAS:528:DC%2BD2MXmvVGnsbY%3D
16. N. Lukan P. Ströbel A. Willer 2009 Cetuximab-based treatment of metastatic anal cancer: correlation of response with Kras mutational status Oncology 77 293 9 10.1159/000259615 1:CAS:528:DC%2BD1MXhsFOhtrfL
17. S.K. Mai G. Welzel B. Hermann 2009 Can the radiation dose to CT-enlarged but FDG-PET-negative inguinal lymph nodes in anal cancer be reduced? Strahlenther Onkol 185 254 9 10.1007/s00066-009-1944-5
18. F. Marquardt F. Rodel G. Capalbo 2009 Molecular targeted treatment and radiation therapy for rectal cancer Strahlenther Onkol 185 371 8 10.1007/s00066-009-1936-5
19. J.A. Martenson S.R. Lipsitz M. Lefkopoulou 1995 Results of combined modality therapy for patients with anal cancer (E7283). An Eastern Cooperative Oncology Group study Cancer 76 1731 6 10.1002/1097-0142(19951115)76:10<1731: AID-CNCR2820761009>3.0.CO;2-H 1:CAS:528:DyaK28XktV2hsA%3D%3D
20. O. Matzinger F. Roelofsen L. Mineur 2009 Mitomycin C with continuous fluorouracil or with cisplatin in combination with radiotherapy for locally advanced anal cancer (European Organisation for Research and Treatment of Cancer phase II study 22011-40014) Eur J Cancer 45 2782 91 10.1016/j.ejca.2009.06.020 1:CAS:528:DC%2BD1MXhtlSqsLzF
21. N.J. Meropol D. Niedzwiecki B. Shank 2008 Induction therapy for poor-prognosis anal canal carcinoma: a phase II study of the Cancer and Leukemia Group B (CALGB 9281) J Clin Oncol 26 3229 34 10.1200/JCO.2008.16.2339 1:CAS:528:DC%2BD1cXptlKgtbg%3D
22. N.D. Nigro V.K. Vaitkevicius B. Considine 1974 Combined therapy for cancer of the anal canal: a preliminary report Dis Colon Rectum 17 354 6 10.1007/BF02586980 1:STN:280:DyaE2c7ntFelsA%3D%3D
23. M. Niyazi P. Marini P.T. Daniel 2009 Efficacy of a triple treatment with irradiation, agonistic TRAIL receptor antibodies and ECFR blockade Strahlenther Onkol 185 8 18 10.1007/s00066-009-1856-4
24. J. Northover R. Glynne-Jones D. Sebag-Montefiore 2010 Chemoradiation for the treatment of epidermoid anal cancer: 13-year follow-up of the first randomised UKCCCR Anal Cancer Trial (ACT I) Br J Cancer 201 1123 8 10.1038/sj.bjc.6605605
25. Olivatto LO, Meton F, Bezerra A, et al. Phase I study of cetuximab (CET) in combination with 5-fluorouracil (5-FU), cisplatin (CP), and radiotherapy (RT) in patients with locally advanced squamous cell anal carcinoma (LAAC). J Clin Oncol 2008;26:Suppl:abstract 4609.
26. L.K. Phan P.M. Hoff 2007 Evidence of clinical activity for cetuximab combined with irinotecan in a patient with refractory anal canal squamous-cell carcinoma: report of a case Dis Colon Rectum 50 395 8 10.1007/s10350-006-0786-9 (Pubitemid 46393970)
27. T.A. Rich J.A. Ajani W.H. Morrison 1993 Chemoradiation therapy for anal cancer: radiation plus continuous infusion of 5-fluorouracil with or without cisplatin Radiother Oncol 27 209 15 10.1016/0167-8140(93)90076-K 1:STN:280:DyaK2c%2FitlSluw%3D%3D
28. I. Sirak J. Petera J. Hatlova 2008 Epidermal growth factor receptor as a predictor of tumor response to preoperative chemoradiation in locally advanced gastric carcinoma Strahlenther Onkol 184 592 7 10.1007/s00066-008-1880-9
29. B. Sischy R.L. Doggett J.M. Krall 1989 Definitive irradiation and chemotherapy for radiosensitization in management of anal carcinoma: interim report on Radiation Therapy Oncology Group study no. 8314 J Natl Cancer Inst 81 850 6 10.1093/jnci/81.11.850 1:STN:280:DyaL1M3lvVymug%3D%3D
30. Van Damme N, Van Roy N, Speleman F, et al. EGFR and Kras status in anal canal cancer. J Clin Oncol 2008;26:Suppl:abstract 15569.
31. M.G. Zampino E. Magni A. Sonzogni 2009 K-ras status in squamous cell anal carcinoma (SCC): it's time for target-oriented treatment? Cancer Chemother Pharmacol 65 197 9 10.1007/s00280-009-1117-3 1:CAS:528:DC%2BD1MXhtFegu73K