Mitomycin C with continuous fluorouracil or with cisplatin in combination with radiotherapy for locally advanced anal cancer (European Organisation for Research and Treatment of Cancer phase II study 22011-40014)

European Journal of Cancer

Volumn 45, Issue 16, 2009, Pages 2782-2791

  Matzinger, O ^a,b   Roelofsen, F ^c   Mineur, L ^d   Koswig, S ^e   Van Der Steen Banasik, E M ^f   Van Houtte, P ^g   Haustermans, K ^h   Radosevic Jelic, L ⁱ   Mueller, R P ^j   Maingon, P ^k   Collette, L ^a   Bosset, J F ^l  

^a EORTC DATA CENTER   (Belgium)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c Bethesda Krankenhaus   (Germany)

^d INSTITUT SAINTE CATHERINE   (France)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^f Arnhems Radiotherapeutisch Instituut   (Netherlands)

^g JULES BORDET INSTITUTE   (Belgium)

^h UNIVERSITY HOSPITALS LEUVEN   (Belgium)

ⁱ INSTITUTE FOR ONCOLOGY AND RADIOLOGY OF SERBIA   (Serbia)

^j Radiation Oncology Department   (Germany)

^k CENTRE GEORGES FRANÇOIS LECLERC   (France)

^l UNIVERSITY HOSPITAL JEAN MINJOZ   (France)

more..

Author keywords

Anal cancer; Cisplatin; Mitomycin C; Radio chemotherapy; Radiotherapy; Randomised trial

Indexed keywords

CISPLATIN; FLUOROURACIL; MITOMYCIN C;

ADULT; ADVANCED CANCER; ANUS CARCINOMA; ARTICLE; BLOOD TOXICITY; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DERMATITIS; DIARRHEA; DISEASE FREE SURVIVAL; DRUG WITHDRAWAL; FEMALE; HAND FOOT SYNDROME; HUMAN; MALE; MUCOSA INFLAMMATION; NEUTROPENIA; PRIORITY JOURNAL; PROCTITIS; RECTUM HEMORRHAGE; SQUAMOUS CELL CARCINOMA; THROMBOCYTOPENIA; TREATMENT DURATION; TREATMENT OUTCOME;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ANUS NEOPLASMS; CARCINOMA, SQUAMOUS CELL; CISPLATIN; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; FEASIBILITY STUDIES; FEMALE; FLUOROURACIL; HUMANS; MALE; MIDDLE AGED; MITOMYCIN; PATIENT COMPLIANCE; TREATMENT OUTCOME;

EID: 70350281270     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2009.06.020     Document Type: Article

References (26)

1. Jemal A., Siegel R., Ward E., et al. Cancer statistics, 2008. CA Cancer J Clin 58 (2008) 71-96
2. Lund J.A., Wibe A., Sundstrom S.H., et al. Anal carcinoma in mid-Norway 1970-2000. Acta Oncol 46 (2007) 1019-1026
3. Frisch M., Glimelius B., van den Brule A.J.C., et al. Sexually transmitted infection as a cause of anal cancer. N Engl J Med 337 (1997) 1350-1358
4. Uronis H.E., and Bendell J.C. Anal cancer: an overview. Oncologist 12 (2007) 524-534
5. Chiao E.Y., Krown S.E., Stier E.A., et al. A population-based analysis of temporal trends in the incidence of squamous anal canal cancer in relation to the HIV epidemic. J Acquir Immune Defic Syndr 40 (2005) 451-455
6. Clark M.A., Hartley A., and Geh J.I. Cancer of the anal canal. Lancet Oncol 5 (2004) 149-157
7. Boman B.M., Moertel C.G., O'Connell M.J., et al. Carcinoma of the anal canal: a clinical and pathologic study of 188 cases. Cancer 54 (1984) 114-125
8. Pintor M.P., Northover J.M., and Nicholls R.J. Squamous cell carcinoma of the anus at one hospital from 1948 to 1984. Br J Surg 76 (1989) 806-810
9. Papillon J. Rectal and anal cancers. Conservative treatment by irradiation. An alternative to radical surgery (1982), Springer-Verlag, Berlin, Heidelberg, New York
10. Nigro N.D., Vaitkevicius V.K., and Considine B. Combined therapy for cancer of the anal canal: a preliminary report. Dis Colon Rectum 17 (1974) 354-356
11. UKCCR. Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin. UKCCCR Anal Cancer Trial Working Party. UK Co-ordinating Committee on Cancer Research. Lancet 1996;348:1049-54.
12. Bartelink H., Roelofsen F., Eschwege F., et al. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups. J Clin Oncol 15 (1997) 2040-2049
13. Flam M., John M., Pajak T.F., et al. Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study. J Clin Oncol 14 (1996) 2527-2539
14. Bosset J.F., Roelofsen F., Morgan D.A., et al. Shortened irradiation scheme, continuous infusion of 5-fluorouracil and fractionation of mitomycin C in locally advanced anal carcinomas. Results of a phase II study of the European Organization for Research and Treatment of Cancer. Radiotherapy and Gastrointestinal Cooperative Groups. Eur J Cancer 39 (2003) 45-51
15. Rich T.A., Ajani J.A., Morrison W.H., et al. Chemoradiation therapy for anal cancer: radiation plus continuous infusion of 5-fluorouracil with or without cisplatin. Radiother Oncol 27 (1993) 209-215
16. Gerard J.P., Ayzac L., Hun D., et al. Treatment of anal canal carcinoma with high dose radiation therapy and concomitant fluorouracil-cisplatinum. Long-term results in 95 patients. Radiother Oncol 46 (1998) 249-256
17. Hung A., Crane C., Delclos M., et al. Cisplatin-based combined modality therapy for anal carcinoma: a wider therapeutic index. Cancer 97 (2003) 1195-1202
18. Sobin L.H., and Wittekind C. TNM classification of malignant tumours. 5th ed. (1997), Wiley-Liss, New York
19. Therasse P., Arbuck S.G., Eisenhauer E.A., et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 92 (2000) 205-216
20. ICRU. ICRU Report 62: Prescribing, Recording and Reporting Photon Beam Therapy (Supplement to ICRU Report 50); 1999.
21. Common Terminology Criteria for Adverse Events v3.0 (CTCAE). .
22. Fleming T.R. One-sample multiple testing procedure for phase II clinical trials. Biometrics 38 (1982) 143-151
23. James RD, David C, Neville D, et al. Chemoradiation and maintenance chemotherapy for patients with anal carcinoma: a phase II trial of the UK co-ordinating committee for cancer research (UKCCCR) anal cancer trial working party. Proc ASCO 2000;19 [abstract 1045].
24. James R., Meadows H., and Wan S. ACT II: the second UK phase III anal cancer trial. Clin Oncol 17 (2005) 364-366
25. Ajani J.A., Winter K.A., Gunderson L.L., et al. Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial. JAMA 299 (2008) 1914-1921
26. Glynne-Jones R., Meadows H., Wan S., et al. EXTRA-A multicenter phase II study of chemoradiation using a 5 day per week oral regimen of capecitabine and intravenous mitomycin C in anal cancer. Int J Radiat Oncol Biol Phys 72 (2008) 119-126