Shortened irradiation scheme, continuous infusion of 5-fluorouracil and fractionation of mitomycin C in locally advanced anal carcinomas. Results of a phase II study of the European Organization for Research and Treatment of Cancer. Radiotherapy and Gastrointestinal Cooperative Groups

European Journal of Cancer

Volumn 39, Issue 1, 2003, Pages 45-51

  Bosset, J F ^a   Roelofsen, F ^b   Morgan, D A L ^c   Budach, V ^d   Coucke, P ^e   Jager, J J ^f   Van der Steen Banasik, E ^g   Triviere N ^h   Stuben G ^b   Puyraveau, M ^a   Mercier, M ^a  

^a UNIVERSITY HOSPITAL OF BESANÇON   (France)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c NOTTINGHAM CITY HOSPITAL   (United Kingdom)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^f MAASTRO CLINIC   (Netherlands)

^g Arnhems Radiotherapeutisch Instituut   (Netherlands)

^h JULES BORDET INSTITUTE   (Belgium)

Author keywords

Accelerated treatment; Anal cancer; Chemoradiotherapy; Phase II clinical trial

Indexed keywords

CISPLATIN; FLUOROURACIL; MITOMYCIN C;

ACUTE TOXICITY; ADULT; AGED; ANUS CARCINOMA; ANUS DISEASE; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DIARRHEA; DRUG DELIVERY SYSTEM; DRUG DOSE; FEMALE; HUMAN; INTESTINE OBSTRUCTION; IRRADIATION; LOBAR PNEUMONIA; MAJOR CLINICAL STUDY; MALE; PATIENT COMPLIANCE; PERINEUM INJURY; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RADIATION DOSE; RANDOMIZED CONTROLLED TRIAL; RESPONSE TIME; TREATMENT PLANNING; TUMOR CLASSIFICATION; WORLD HEALTH ORGANIZATION;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ANUS NEOPLASMS; COMBINED MODALITY THERAPY; DRUG ADMINISTRATION SCHEDULE; FEASIBILITY STUDIES; FEMALE; FLUOROURACIL; FOLLOW-UP STUDIES; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; MITOMYCIN; RADIOTHERAPY DOSAGE;

EID: 0037215152     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(02)00377-5     Document Type: Article

References (21)

1. Epidermoïd anal cancer. results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin Lancet. 348:1996;1049-1054.
2. Bartelink H., Roelofsen F., Eschwege F.et al. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer. results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups J. Clin. Oncol. 15:1997;2040-2049.
3. Flam M., John M., Pajak T.F.et al. Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal cancer. results of a phase III Randomized Intergroup Study J. Clin. Oncol. 14:1996;2527-2539.
4. Bosset J.F., Pavy J.J., Roelofsen F., Bartelink H. Combined radiotherapy and chemotherapy for anal cancer. Lancet. 349:1997;205-206.
5. Sobin L.H., Wittekind C. TNM Classification of Malignant Tumours. 5th edn. 1997;Wiley-Liss, New York.
6. Miller A.B., Hoogstraten B., Staquet M., Winkler A. Reporting results of cancer treatment. Cancer. 47:1981;107-214.
7. Pavy J.J., Denekamp J., Letschert J.et al. EORTC late effects working group. Late effects toxicity scoring. the SOMA scale Radiother. Oncol. 35:1995;11-15.
8. Papillon J. Rectal and Anal Cancers. Conservative Treatment by Irradiation - An Alternative to Radical Surgery. 1982;Springer-Verlag, Berlin, Heidelberg, New York.
9. Papillon J., Montbarbon J. Epidermoid carcinoma of the anal canal. a series of 276 cases Dis. Colon Rectum. 30:1987;324-333.
10. Cummings B. The place of radiation therapy in the treatment of carcinoma of the anal canal. Cancer Treat. Rev. 9:1982;125-147.
11. Eschwege F., Lasser P., Chavy A.et al. Squamous cell carcinoma of the anal canal. treatment by external beam irradiation Radiat. Oncol. 3:1985;145-150.
12. Doggett S.W., Green J.P., Cantril S.T. Efficacy of radiation therapy alone for limited squamous cell carcinoma of the anal canal. Int. J. Radiat. Oncol. Biol. Phys. 15:1988;1069-1072.
13. Schlienger M., Krzisch C., Pene F.et al. Epidermoid carcinoma of the anal canal treatment results and prognostic variables in a series of 242 cases. Int. J. Radiat. Oncol. Biol. Phys. 17:1989;1141-1151.
14. Zelnick R.S., Haas P.A., Aljouni M., Szilagyi E., Fox T.A. Results of abdominoperineal resections for failures after combination chemotherapy and radiation therapy for anal cancers. Dis Colon Rectum. 35:1992;574-578.
15. Grabenbauer G.G., Matzel K.E., Schneider I.H.F.et al. Sphincter preservation with chemoradiation in anal canal carcinoma. Dis. Colon Rectum. 41:1998;441-450.
16. Allal A.S., Laurencet F.M., Reymond M.A., Kurtz J.M., Marti M.C. Effectiveness of surgical salvage therapy for patients with locally uncontrolled anal carcinoma after sphincter-conserving treatment. Cancer. 86:1999;405-409.
17. Fowler J.F., Lindstrom M.J. Loss of local control with prolongation in radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 23:1992;457-467.
18. Peiffert D., Bey P., Pernot M.et al. Conservative treatment by irradiation of epidermoid cancers of the anal canal. prognostic factors of tumoral control and complications Int. J. Radiat. Oncol. Biol. Phys. 37:1997;313-324.
19. Allal A.S., Mermillod B., Roth A.D., Marti M.C., Kurtz J.M. The impact of treatment factors of local control in T2-T3 anal carcinomas treated by radiotherapy with or without chemotherapy. Cancer. 79:1997;2329-2335.
20. John M., Pajak T., Flam M.et al. Dose escalation in chemoradiation for anal cancer. preliminary results of RTOG 92-08 Cancer J. Sci. Am. 2:1996;205.
21. Rich T.A., Ajani J.A., Morrison W.H., Ota D., Levin B. Chemoradiation therapy for anal cancer. radiation plus continuous infusion of 5-fluorouracil with or without cisplatin Radiother. Oncol. 27:1993;209-215.