Analysis of methylation patterns and expression profiles of p14 ARF gene in patients with oral squamous cell carcinoma

International Journal of Biological Markers

Volumn 25, Issue 2, 2010, Pages 99-103

  Kordi Tamandani, Dor Mohammad ^a   Moazeni Roodi, Abdolkarim ^a   Ladez, Mohammad Ayoub Rigi ^b   Hashemi, Mohammad ^c   Birjandian, Elnaz ^a   Torkamanzehi, Adam ^a  

^a UNIVERSITY OF SISTAN AND BALUCHESTAN   (Iran)

^b ZAHEDAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ZAHEDAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Gene expression; Oral squamous cell carcinoma; P14ARF gene; Promoter methylation

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; GENOMIC DNA; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; PARAFFIN;

ADULT; ARTICLE; CANCER STAGING; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA EXTRACTION; EARLY DIAGNOSIS; FEMALE; GENE EXPRESSION PROFILING; GENE SEQUENCE; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MOLECULAR GENETICS; MOUTH CARCINOMA; ORAL SQUAMOUS CELL CARCINOMA; POLYMERASE CHAIN REACTION; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN METHYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SQUAMOUS CELL CARCINOMA; AGED; CARCINOMA, SQUAMOUS CELL; CASE CONTROL STUDY; DNA METHYLATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; MOUTH NEOPLASMS; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; DNA METHYLATION; EARLY DETECTION OF CANCER; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; MOUTH NEOPLASMS; PROMOTER REGIONS, GENETIC; TUMOR SUPPRESSOR PROTEIN P14ARF;

EID: 77954914152     PISSN: 03936155     EISSN: None     Source Type: Journal    
DOI: 10.1177/172460081002500207     Document Type: Article

References (23)

1. World Health Organization. The World Health Report 2004 - Changing History. Geneva: WHO, 2004.
2. Mousavi SM, Gouya MM, Ramazani R, Davanlou M, Hajsadeghi N, Seddighi Z. Cancer incidence and mortality in Iran. Ann Oncol 2009; 20: 556-63.
3. Petersen PE. Oral cancer prevention and control - the approach of the World Health Organization. Oral Oncol 2009; 45: 454-60.
4. Feinberg AP, Vogelstein B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 1983; 301: 89-92. (Pubitemid 13154475)
5. Ding Z, Qian Yb, Zhu Lx, xiong QR. Promoter methylation and mRNA expression of DKK-3 and WIF-1 in hepatocellular carcinoma. World J Gastroenterol 2009; 15: 2595-601.
6. Ruas M, Peters G. The p16INK4a/CDKN2A tumor suppressor and its relatives. Biochim Biophys Acta 1998; 1378: F115-77.
7. Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993; 366: 704-7. (Pubitemid 24036021)
8. Sherr CJ, Roberts JM. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 1995; 9: 1149-63.
9. Weinberg RA The retinoblastoma protein and cell cycle control. Cell 1995; 81: 323-30.
10. Kamijo T, Weber JD, Zambetti G, Zindy F, Roussel MF, Sherr CJ. Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2. Proc Natl Acad Sci U S A 1998; 95: 8292-7. (Pubitemid 28326106)
11. Kamijo T, Zindy F, Roussel MF, et al. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 1997; 91: 649-59.
12. Berggren P, Kumar R, Sakano S, et al. Detecting homozygous deletions in the CDKN2A(p16(INK4a))/ARF(p14(ARF)) gene in urinary bladder cancer using real-time quantitative PCR. Clin Cancer Res 2003; 9: 235-42.
13. Esteller M, Tortola S, Toyota M, et al. Hypermethylation associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status. Cancer Res 2000; 60: 129-33. (Pubitemid 30058742)
14. Sato F, Harpaz N, Shibata D, et al. Hypermethylation of the p14(ARF) gene in ulcerative colitis-associated colorectal carcinogenesis. Cancer Res 2002; 62: 1148-51.
15. Kang MY, Lee BB, Ji YI, et al. Association of interindividual differences in p14ARF promoter methylation with single nucleotide polymorphism in primary colorectal cancer. Cancer 2008; 112: 1699-707.
16. Uhrinova S, Uhrin D, Powers H, et al. Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding. J Mol Biol 2005; 350: 587-98. (Pubitemid 40828916)
17. De Jong WK, Verpooten GF, Kramer H, Louwagie J, Groen HJ. Promoter methylation primarily occurs in tumor cells of patients with non-small cell lung cancer. Anticancer Res 2009; 29: 363-9.
18. Ellinger J, Albers P, Perabo FG, Muller SC, Von Ruecker A, Bastian PJ. CpG island hypermethylation of cell-free circulating serum DNA in patients with testicular cancer. J Urol 2009; 182: 324-9.
19. Kuo LT, Kuo KT, Lee MJ. Correlation among pathology, genetic and epigenetic profiles, and clinical outcome in oligodendroglial tumors. Int J Cancer 2009; 124: 2872-9.
20. Phé V, Cussenot O, Rouprêt M. Interest of methylated genes as biomarkers in urothelial cell carcinomas of the urinary tract. BJU Int 2009, June 12 [Epub ahead of print].
21. Tahara T, Shibata T, Arisawa T, et al. Impact of catechol-O- methyltransferase (COMT) gene polymorphism on promoter methylation status in gastric mucosa. Anticancer Res 2009; 29: 2857-61.
22. Sharma G, Mirza S, Prasad CP, Srivastava A, Gupta SD, Ralhan R. Promoter hypermethylation of p16INK4A, p14ARF, CyclinD2 and Slit2 in serum and tumor DNA from breast cancer patients. Life Sci 2007; 80: 1873-81.
23. Sailasree R, Abhilash A, Sathyan KM, Nalinakumari KR, Thomas S, Kannan S. Differential roles of p16INK4A and p14ARF genes in prognosis of oral carcinoma. Cancer Epidemiol Biomarkers Prev 2008; 17: 414-20.