Impact of catechol-O-methyltransferase (COMT) gene polymorphism on promoter methylation status in gastric mucosa

Anticancer Research

Volumn 29, Issue 7, 2009, Pages 2857-2861

  Tahara, Tomomitsu ^a,b   Shibata, Tomoyuki ^a   Arisawa, Tomiyasu ^a   Nakamura, Masakatsu ^a   Yamashita, Hiromi ^a   Yoshioka, Daisuke ^a   Okubo, Masaaki ^a   Maruyama, Naoko ^a   Kamano, Toshiaki ^a   Kamiya, Yoshio ^a   Fujita, Hiroshi ^a   Nagasaka, Mitsuo ^a   Iwata, Masami ^a   Takahama, Kazuya ^a   Watanabe, Makoto ^a   Hirata, Ichiro ^a  

^a FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NONE   (Japan)

Author keywords

COMT; Gastric mucosa; Helicobacter pylori; Methylation; Polymorphism

Indexed keywords

CATECHOL METHYLTRANSFERASE; METHIONINE; PROTEIN P14; PROTEIN P16; VALINE;

ADULT; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GASTROINTESTINAL ENDOSCOPY; GROUPS BY AGE; HELICOBACTER INFECTION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PEPTIC ULCER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN METHYLATION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEX DIFFERENCE; STOMACH MUCOSA;

BASE SEQUENCE; CATECHOL O-METHYLTRANSFERASE; CELL TRANSFORMATION, NEOPLASTIC; DNA METHYLATION; DNA PRIMERS; GASTRIC MUCOSA; HUMANS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC;

EID: 69249163899     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Issa JP, Ottaviano YL, Celano P, Hamilton SR, Davidson NE and Baylin SB: Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet 7: 536-540, 1994. (Pubitemid 24308343)
2. Ahuja N, Li Q, Mohan AL, Baylin SB and Issa JP: Aging and DNA methylation in colorectal mucosa and cancer. Cancer Res 58: 5489-5494, 1998. (Pubitemid 28551135)
3. Sato F, Harpaz N, Shibata D, Xu Y, Yin J, Mori Y, Zou TT, Wang S, Desai K, Leytin A, Selaru FM, Abraham JM and Meltzer SJ: Hypermethylation of the p14(ARF) gene in ulcerative colitis-associated colorectal carcinogenesis. Cancer Res 62: 1148-1151, 2002. (Pubitemid 34160301)
4. Issa JP, Ahuja N, Toyota M, Bronner MP and Brentnall TA. Accelerated age-related CpG island methylation in ulcerative colitis. Cancer Res 61: 3573-3577, 2001. (Pubitemid 32694963)
5. Bian YS, Osterheld MC, Fontolliet C, Bosman FT and Benhattar J: p16 inactivation by methylation of the CDKN2A promoter occurs early during neoplastic progression in Barrett's esophagus. Gastroenterology 122: 1113-1121, 2002. (Pubitemid 34267292)
6. Wong DJ, Paulson TG, Prevo LJ, Galipeau PC, Longton G, Blount PL and Reid BJ: p16(INK4a) lesions are common, early abnormalities that undergo clonal expansion in Barrett's metaplastic epithelium. Cancer Res 61: 8284-8289, 2001. (Pubitemid 33091623)
7. Kaneto H, Sasaki S, Yamamoto H, Itoh F, Toyota M, Suzuki H, Ozeki I, Iwata N, Ohmura T, Satoh T, Karino Y, Satoh T, Toyota J, Satoh M, Endo T, Omata M and Imai K: Detection of hypermethylation of the p16(INK4A) gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus. Gut 48: 372-377, 2001. (Pubitemid 32269566)
8. Chan AO, Lam SK, Wong BC, Wong WM, Yuen MF, Yeung YH, Hui WM, Rashid A and Kwong YL: Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer. Gut 52: 502-506, 2003. (Pubitemid 36363400)
9. Maekita T, Nakazawa K, Mihara M, Nakajima T, Yanaoka K, Iguchi M, Arii K, Kaneda A, Tsukamoto T, Tatematsu M, Tamura G, Saito D, Sugimura T, Ichinose M and Ushijima T: High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin Cancer Res 12: 989-995, 2006. (Pubitemid 43259882)
10. Kang GH, Lee HJ, Hwang KS, Lee S, Kim JH and Kim J: Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation. Am J Pathol 163: 1551-1556, 2003. (Pubitemid 37175101)
11. Tahara T, Arisawa T, Shibata T, Wang FY, Nakamura M, Sakata M, Nagasaka M, Takagi T, Kamiya Y, Fujita H, Nakamura M, Hasegawa S, Iwata M, Takahama K, Watanabe M, Hirata I and Nakano H: Risk prediction of gastric cancer by analysis of aberrant DNA methylation in non-neoplastic gastric epithelium. Digestion 75: 54-61, 2007. (Pubitemid 46712755)
12. Kaise M, Yamasaki T, Yonezawa J, Miwa J, Ohta Y and Tajiri H: CpG island hypermethylation of tumor-suppressor genes in H. pylori-infected non-neoplastic gastric mucosa is linked with gastric cancer risk. Helicobacter 13: 35-41, 2008.
13. Nakajima T, Maekita T, Oda I, Gotoda T, Yamamoto S, Umemura S, Ichinose M, Sugimura T, Ushijima T and Saito D: Higher methylation levels in gastric mucosae significantly correlate with higher risk of gastric cancers. Cancer Epidemiol Biomarkers Prev 15: 2317-2321, 2006. (Pubitemid 44877064)
14. ARF tumour suppressor mediate nucleolar localization. Oncogene 19: 2978-2985, 2000. (Pubitemid 30389088)
15. Tannapfel A, Busse C, Weinans L, Benicke M, Katalinic A, Geissler F, Hauss J and Wittekind C: INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas. Oncogene 20: 7104-7109, 2001. (Pubitemid 33052203)
16. Toyota M, Ahuja N, Suzuki H, Itoh F, Ohe-Toyota M, Imai K, Baylin SB and Issa JP: Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype. Cancer Res 59: 5438-5442, 1999. (Pubitemid 29526452)
17. Kang GH, Shim YH, Jung HY, Kim WH, Ro JY and Rhyu MG: CpG island methylation in premalignant stages of gastric carcinoma. Cancer Res 61: 2847-2851, 2001.
18. Matsumoto M, Weickert CS, Beltaifa S, Kolachana B, Chen J, Hyde TM, Herman MM, Weinberger DR and Kleinman JE: Catechol O-methyltransferase (COMT) mRNA expression in the dorsolateral prefrontal cortex of patients with schizophrenia. Neuropsychopharmacology 28: 1521-1530, 2003. (Pubitemid 41070888)
19. Tenhunen J, Salminen M, Jalanko A, Ukkonen S and Ulmanen I: Structure of the rat catechol-O-methyltransferase gene: separate promoters are used to produce mRNAs for soluble and membrane-bound forms of the enzyme. DNA Cell Biol 12: 253-263, 1993. (Pubitemid 23121007)
20. Lundstrom K, Tenhunen J, Tilgmann C, Karhunen T, Panula P and Ulmanen I: Cloning, expression and structure of catechol-O-methyltransferase. Biochim Biophys Acta 1251: 1-10, 1995.
21. Zhu BT, Ezell EL and Liehr JG: Catechol-O-methyltransferase-catalyzed rapid O-methylation of mutagenic flavonoids. Metabolic inactivation as a possible reason for their lack of carcinogenicity in vivo. J Biol Chem 269: 292-299, 1994.
22. Zhu BT: Catechol-O-methyltransferase (COMT)-mediated methylation metabolism of endogenous bioactive catechols and modulation by endobiotics and xenobiotics: importance in pathophysiology and pathogenesis. Curr Drug Metab 3: 321-349, 2002.
23. Lotta T, Vidgren J, Tilgmann C, Ulmanen I, Melén K, Julkunen I and Taskinen J: Kinetics of human soluble and membrane-bound catechol O-methyltransferase a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 34: 4202-4210, 1995.
24. Esteller M, Tortola S, Toyota M, Capella G, Peinado MA, Baylin SB and Herman JG: Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status. Cancer Res 60: 129-133, 2000. (Pubitemid 30058742)
25. Herman JG, Graff JR, Myöhänen S, Nelkin BD and Baylin SB: Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 93: 9821-9826, 1996. (Pubitemid 26296693)
26. Chen J, Lipska BK, Halim N, Ma QD, Matsumoto M, Melhem S, Kolachana BS, Hyde TM and Herman MM, Apud J, Egan MF, Kleinman JE, Weinberger DR: Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am J Hum Genet 75: 807-821, 2004. (Pubitemid 39390488)
27. Skibola CF, Bracci PM, Paynter RA, Forrest MS, Agana L, Woodage T, Guegler K, Smith MT and Holly EA: Polymorphisms and haplotypes in the cytochrome P450 17A1, prolactin, and catechol-O-methyltransferase genes and non-Hodgkin lymphoma risk. Cancer Epidemiol Biomarkers Prev 14: 2391-2401, 2005. (Pubitemid 41437842)
28. Lavigne JA, Helzlsouer KJ, Huang HY, Strickland PT, Bell DA, Selmin O, Watson MA, Hoffman S, Comstock GW and Yager JD: An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer. Cancer Res 57: 5493-5497, 1997. (Pubitemid 28006754)
29. Goodman MT, McDuffie K, Kolonel LN, Terada K, Donlon TA, Wilkens LR, Guo C and Le Marchand L: Case-control study of ovarian cancer and polymorphisms in genes involved in catecholestrogen formation and metabolism. Cancer Epidemiol Biomarkers Prev 10: 209-216, 2001. (Pubitemid 34288531)
30. Suzuki M, Mamun MR, Hara K, Ozeki T, Yamada Y, Kadowaki T, Honda H, Yanagihara Y, Ito YM, Kameyama S, Ohta N, Hosoi T, Arai T, Sawabe M, Takeuchi T, Takahashi S and Kitamura T: The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progression-free survival in prostate cancer patients treated with estramustine phosphate. Eur Urol 48: 752-759, 2005. (Pubitemid 41495373)
31. Issa JP: GpG-island methylation in aging and cancer. Curr Top Microbiol Immunol 249: 101-118, 2000.
32. Asaka M, Sugiyama T, Nobuta A, Kato M, Takeda H and Graham DY: Atrophic gastritis and intestinal metaplasia are strongly related to Helicobacter pylori infection and not to aging in Japan: results of a large multi-center study. Helicobacter 6: 294-299, 2001.
33. Naito Y and Yoshikawa T: Molecular and cellular mechanisms involved in Helicobacter pylori-induced inflammation and oxidative stress. Free Radic Biol Med 33: 323-336, 2002. (Pubitemid 34786272)