Identification of an ABCB/P-glycoprotein-specific inhibitor of auxin transport by chemical genomics

Journal of Biological Chemistry

Volumn 285, Issue 30, 2010, Pages 23309-23317

  Kim, Jun Young ^a   Henrichs, Sina ^b   Bailly, Aurélien ^b   Vincenzetti, Vincent ^b   Sovero, Valpuri ^b   Mancuso, Stefano ^c   Pollmann, Stephan ^d   Kim, Daehwang ^e   Geisler, Markus ^b   Nam, Hong Gil ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF FLORENCE   (Italy)

^d RUHR UNIVERSITY BOCHUM   (Germany)

^e Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2-HYDROXYBENZOYL; ATP-BINDING CASSETTE; AUXIN TRANSPORT; AUXIN TRANSPORT INHIBITORS; BENZOIC ACID; BINDING ASSAYS; CELLULAR EFFLUX; GENOMICS; IC50 VALUE; MEMBRANE TRAFFICKING; MULTIDRUG RESISTANCE; NUCLEOTIDE BINDING; P-GLYCOPROTEIN; PLANT DEVELOPMENT; PLANT PHYSIOLOGY; SIGNALING MOLECULES; SPECIFIC INHIBITORS;

ACIDS; CHEMOTHERAPY; GLYCOPROTEINS; HERBICIDES; PROTEINS;

TARGETS;

1 N NAPHTYLPHTALAMIC ACID; 2 [4 (DIETHYLAMINO) 2 HYDROXYBENZOYL]BENZOIC ACID; AUXIN; BENZOIC ACID DERIVATIVE; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; GRAVACIN; MULTIDRUG RESISTANCE PROTEIN 1; PIN FORMED PROTEIN; UNCLASSIFIED DRUG; VEGETABLE PROTEIN;

ARABIDOPSIS; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; GENOMICS; GRAVITROPISM; MEMBRANE TRANSPORT; NONHUMAN; PLANT DEVELOPMENT; PLANT GROWTH; PLANT PHYSIOLOGY; PLANT ROOT; PRIORITY JOURNAL; PROTEIN TRANSPORT; SHOOT;

ARABIDOPSIS; BENZOIC ACID; BIOLOGICAL TRANSPORT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION, PLANT; GENOMICS; INDOLEACETIC ACIDS; MODELS, MOLECULAR; P-GLYCOPROTEIN; PROTEIN CONFORMATION; SMALL MOLECULE LIBRARIES; SUBSTRATE SPECIFICITY;

EID: 77954890373     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.105981     Document Type: Article

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