Biomarkers as end points in clinical trials of severe sepsis: A garden of forking paths

Critical Care Medicine

Volumn 38, Issue 8, 2010, Pages 1749-1751

  Salluh, Jorge I F ^a   Póvoa, Pedro ^b,c  

^a INSTITUTO NACIONAL DE CÂNCER   (Brazil)

^b Polyvalent Intensive Care Unit   (Portugal)

^c UNIVERSIDADE NOVA DE LISBOA   (Portugal)

Author keywords

biomarkers; cytokines; outcomes; risk assessment; severe sepsis

Indexed keywords

6 [N (2 CHLORO 4 FLUOROPHENYL)SULFAMOYL] 1 CYCLOHEXENE 1 CARBOXYLIC ACID ETHYL ESTER; BIOLOGICAL MARKER; INTERLEUKIN 6;

CLINICAL TRIAL; DISEASE SEVERITY; DRUG TREATMENT FAILURE; EDITORIAL; EVIDENCE BASED PRACTICE; GRAM NEGATIVE INFECTION; HUMAN; INTENSIVE CARE UNIT; MORTALITY; OUTCOME ASSESSMENT; PATIENT CARE; PRIORITY JOURNAL; RESPIRATORY FAILURE; SEPSIS; SHOCK; SIGNAL TRANSDUCTION;

EID: 77954889415     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181e941f6     Document Type: Editorial

References (12)

1. Angus DC, Linde-Zwirble WT, Lidicker J, et al: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29:1303-1310
2. Levy MM, Dellinger RP, Townsend SR, et al: The Surviving Sepsis Campaign: Results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med 2010; 36:222-231
3. Rice TW, Wheeler AP, Bernard GR, et al: A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. Crit Care Med 2010; 38:1685-1694
4. Bozza FA, Salluh JI, Japiassu AM, et al: Cytokine profiles as markers of disease severity in sepsis: A multiplex analysis. Crit Care 2007; 11:R49
5. Ulloa L, Tracey KJ: The "cytokine profile": A code for sepsis. Trends Mol Med 2005; 11:56-63
6. Kellum JA, Kong L, Fink MP, et al: Understanding the inflammatory cytokine response in pneumonia and sepsis: Results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med 2007; 167:1655-1663
7. Marshall JC, Reinhart K: Biomarkers of sepsis. Crit Care Med 2009; 37:2290-2298
8. Seely AJ, Christou NV: Multiple organ dysfunction syndrome: Exploring the paradigm of complex nonlinear systems. Crit Care Med 2000; 28:2193-2200
9. Salluh JI, Bozza PT: Biomarkers of sepsis: lost in translation? Crit Care Med 2008; 36: 2192-2194
10. Macias WL, Nelson DR, Williams M, et al: Lack of evidence for qualitative treatment by disease severity interactions in clinical studies of severe sepsis. Crit Care 2005; 9:R607-R622
11. Povoa P: Serum markers in community-acquired pneumonia and ventilator-associated pneumonia. Curr Opin Infect Dis 2008; 21:157-162
12. Jansen TC, van Bommel J, Schoonderbeek J, et al: Early lactate-guided therapy in ICU patients: A multicenter, open-label, randomized, controlled trial. Am J Respir Crit Care Med 2010 May 12 [Epub ahead of print]