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Volumn 23, Issue 4, 2010, Pages 311-319

Molecular diagnosis of bloodstream infections: Planning to (physically) reach the bedside

Author keywords

broad range PCR; molecular identification; PCR whole blood; rapid identification; realtime PCR

Indexed keywords

AMPLICON; BACTERIUM CULTURE; BACTERIUM ISOLATION; BLOOD CULTURE; BLOODSTREAM INFECTION; DIAGNOSTIC PROCEDURE; GEL ELECTROPHORESIS; HUMAN; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MICROARRAY ANALYSIS; NONHUMAN; PROGNOSIS; REAL TIME POLYMERASE CHAIN REACTION; REVIEW; BACTEREMIA; BACTERIUM IDENTIFICATION; HOSPITAL INFORMATION SYSTEM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MOLECULAR DIAGNOSIS; POLYMERASE CHAIN REACTION; PROCEDURES; TIME; TRENDS;

EID: 77954875923     PISSN: 09517375     EISSN: 14736527     Source Type: Journal    
DOI: 10.1097/QCO.0b013e32833bfc44     Document Type: Review
Times cited : (44)

References (50)
  • 1
    • 0032779611 scopus 로고    scopus 로고
    • Variations in etiology of ventilator-associated pneumonia across four treatment sites: Implications for antimicrobial prescribing practices
    • Rello J, Sa-Borges M, Correa H, et al. Variations in etiology of ventilator-associated pneumonia across four treatment sites: implications for antimicrobial prescribing practices. Am J Respir Crit Care Med 1999; 160:608-613.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 608-613
    • Rello, J.1    Sa-Borges, M.2    Correa, H.3
  • 2
    • 0242266613 scopus 로고    scopus 로고
    • Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis
    • Harbarth S, Garbino J, Pugin J, et al. Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis. Am J Med 2003; 115:529-535.
    • (2003) Am J Med , vol.115 , pp. 529-535
    • Harbarth, S.1    Garbino, J.2    Pugin, J.3
  • 3
    • 0141610906 scopus 로고    scopus 로고
    • The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting
    • Ibrahim EH, Sherman G, Ward S, et al. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest 2000; 118:146-155.
    • (2000) Chest , vol.118 , pp. 146-155
    • Ibrahim, E.H.1    Sherman, G.2    Ward, S.3
  • 4
    • 70350580290 scopus 로고    scopus 로고
    • Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock
    • Kumar A, Ellis P, Arabi Y, et al. Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest 2009; 136:1237-1248.
    • (2009) Chest , vol.136 , pp. 1237-1248
    • Kumar, A.1    Ellis, P.2    Arabi, Y.3
  • 5
    • 0038555339 scopus 로고    scopus 로고
    • Community-acquired bloodstream infection in critically ill adult patients: Impact of shock and inappropriate antibiotic therapy on survival
    • Valles J, Rello J, Ochagavia A, et al. Community-acquired bloodstream infection in critically ill adult patients: impact of shock and inappropriate antibiotic therapy on survival. Chest 2003; 123:161 5-1624.
    • (2003) Chest , vol.123 , pp. 1615-1624
    • Valles, J.1    Rello, J.2    Ochagavia, A.3
  • 6
    • 33744527833 scopus 로고    scopus 로고
    • Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock
    • Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006; 34:1589-1596.
    • (2006) Crit Care Med , vol.34 , pp. 1589-1596
    • Kumar, A.1    Roberts, D.2    Wood, K.E.3
  • 8
    • 77950462078 scopus 로고    scopus 로고
    • Comparison of two matrix-assisted laser desorption ionization-time of flight mass spectrometry methods with conventional phenotypic identification for routine identification of bacteria to the species level
    • Cherkaoui A, Hibbs J, Emonet S, et al. Comparison of two matrix-assisted laser desorption ionization-time of flight mass spectrometry methods with conventional phenotypic identification for routine identification of bacteria to the species level. J Clin Microbiol 2010; 48:1169-1175.
    • (2010) J Clin Microbiol , vol.48 , pp. 1169-1175
    • Cherkaoui, A.1    Hibbs, J.2    Emonet, S.3
  • 9
    • 75649119276 scopus 로고    scopus 로고
    • Rapid identification of bacteria in positive blood culture broths by matrix-assisted laser desorption ionization-time of flight mass spectrometry
    • Stevenson LG, Drake SK, Murray PR. Rapid identification of bacteria in positive blood culture broths by matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol 2010; 48:444-447.
    • (2010) J Clin Microbiol , vol.48 , pp. 444-447
    • Stevenson, L.G.1    Drake, S.K.2    Murray, P.R.3
  • 10
    • 77950508078 scopus 로고    scopus 로고
    • Matrix-assisted laser desorption ionization-time of flight mass spectrometry for direct bacterial identification from positive blood culture pellets
    • Prod?hom G, Bizzini A, Durussel C, et al. Matrix-assisted laser desorption ionization-time of flight mass spectrometry for direct bacterial identification from positive blood culture pellets. J Clin Microbiol 2010; 48:1481-1483.
    • (2010) J Clin Microbiol , vol.48 , pp. 1481-1483
    • Prodhom, G.1    Bizzini, A.2    Durussel, C.3
  • 11
    • 65249159001 scopus 로고    scopus 로고
    • Truncated human cytidylate-phos-phate-deoxyguanylate-binding protein for improved nucleic acid amplification technique-based detection of bacterial species in human samples
    • Sachse S, Straube E, Lehmann M, et al. Truncated human cytidylate-phos-phate-deoxyguanylate-binding protein for improved nucleic acid amplification technique-based detection of bacterial species in human samples. J Clin Microbiol 2009; 47:1050-1057.
    • (2009) J Clin Microbiol , vol.47 , pp. 1050-1057
    • Sachse, S.1    Straube, E.2    Lehmann, M.3
  • 12
    • 53249142137 scopus 로고    scopus 로고
    • Rapid detection of pathogens in blood culture bottles by real-time PCR in conjunction with the preanalytic tool MolYsis
    • Gebert S, Siegel D, Wellinghausen N. Rapid detection of pathogens in blood culture bottles by real-time PCR in conjunction with the preanalytic tool MolYsis. J Infect 2008; 57:307-316.
    • (2008) J Infect , vol.57 , pp. 307-316
    • Gebert, S.1    Siegel, D.2    Wellinghausen, N.3
  • 13
    • 74249100609 scopus 로고    scopus 로고
    • Accurate and rapid identification of bacterial species from positive blood cultures with a DNA-based microarray platform: An observational study
    • Tissari P, Zumla A, Tarkka E, et al. Accurate and rapid identification of bacterial species from positive blood cultures with a DNA-based microarray platform: an observational study. Lancet 2010; 375:224-230.
    • (2010) Lancet , vol.375 , pp. 224-230
    • Tissari, P.1    Zumla, A.2    Tarkka, E.3
  • 14
    • 69949087599 scopus 로고    scopus 로고
    • Diagnosis of bacteremia in whole-blood samples by use of a commercial universal 16S rRNA gene-based PCR and sequence analysis
    • Wellinghausen N, Kochem AJ, Disque C, et al. Diagnosis of bacteremia in whole-blood samples by use of a commercial universal 16S rRNA gene-based PCR and sequence analysis. J Clin Microbiol 2009; 47:2759-2765.
    • (2009) J Clin Microbiol , vol.47 , pp. 2759-2765
    • Wellinghausen, N.1    Kochem, A.J.2    Disque, C.3
  • 15
    • 45449094597 scopus 로고    scopus 로고
    • Ibis T5000: A universal biosensor approach for microbiology
    • Ecker DJ, Sampath R, Massire C, et al. Ibis T5000: a universal biosensor approach for microbiology. Nat Rev Microbiol 2008; 6:553-558.
    • (2008) Nat Rev Microbiol , vol.6 , pp. 553-558
    • Ecker, D.J.1    Sampath, R.2    Massire, C.3
  • 16
    • 34250329156 scopus 로고    scopus 로고
    • Rapid identification of emerging infectious agents using PCR and electrospray ionization mass spectrometry
    • Sampath R, Hall TA, Massire C, et al. Rapid identification of emerging infectious agents using PCR and electrospray ionization mass spectrometry. Ann N Y Acad Sci 2007; 1102:109-120.
    • (2007) Ann N y Acad Sci , vol.1102 , pp. 109-120
    • Sampath, R.1    Hall, T.A.2    Massire, C.3
  • 17
    • 67651108596 scopus 로고    scopus 로고
    • Ongoing revolution in bacteriology: Routine identification of bacteria by matrix-assisted laser desorption ionization time-of-flight mass spectrometry
    • Seng P, Drancourt M, Gouriet F, et al. Ongoing revolution in bacteriology: routine identification of bacteria by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Clin Infect Dis 2009; 49:543-551.
    • (2009) Clin Infect Dis , vol.49 , pp. 543-551
    • Seng, P.1    Drancourt, M.2    Gouriet, F.3
  • 18
    • 77953920184 scopus 로고    scopus 로고
    • Preliminary clinical study using a multiplex real-time PCR test for the detection of bacterial and fungal DNA directly in blood
    • Wallet F, Nseir S, Baumann L, et al. Preliminary clinical study using a multiplex real-time PCR test for the detection of bacterial and fungal DNA directly in blood. Clin Microbiol Infect 2009; 16:774-779.
    • (2009) Clin Microbiol Infect , vol.16 , pp. 774-779
    • Wallet, F.1    Nseir, S.2    Baumann, L.3
  • 19
    • 77953889323 scopus 로고    scopus 로고
    • Molecular identification of blood stream pathogens in patients presenting to the emergency room with suspected sepsis
    • [Epub ahead of print]
    • Avolio M, Diamante P, Zamparo S, et al. Molecular identification of blood stream pathogens in patients presenting to the emergency room with suspected sepsis. Shock 2010 [Epub ahead of print].
    • (2010) Shock
    • Avolio, M.1    Diamante, P.2    Zamparo, S.3
  • 20
    • 73349137967 scopus 로고    scopus 로고
    • Potential clinical utility of polymerase chain reaction in microbiological testing for sepsis
    • Lehmann LE, Alvarez J, Hunfeld KP, et al. Potential clinical utility of polymerase chain reaction in microbiological testing for sepsis. Crit Care Med 2009; 37:3085-3090.
    • (2009) Crit Care Med , vol.37 , pp. 3085-3090
    • Lehmann, L.E.1    Alvarez, J.2    Hunfeld, K.P.3
  • 21
    • 77951210696 scopus 로고    scopus 로고
    • A multicenter trial to compare blood culture with polymerase chain reaction in severe human sepsis
    • Bloos F, Hinder F, Becker K, et al. A multicenter trial to compare blood culture with polymerase chain reaction in severe human sepsis. Intensive Care Med 2010; 36:241-247.
    • (2010) Intensive Care Med , vol.36 , pp. 241-247
    • Bloos, F.1    Hinder, F.2    Becker, K.3
  • 22
    • 70349779856 scopus 로고    scopus 로고
    • Clinical impact of a commercially available multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis
    • Dierkes C, Ehrenstein B, Siebig S, et al. Clinical impact of a commercially available multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis. BMC Infect Dis 2009; 9:126.
    • (2009) BMC Infect Dis , vol.9 , pp. 126
    • Dierkes, C.1    Ehrenstein, B.2    Siebig, S.3
  • 23
    • 42949089382 scopus 로고    scopus 로고
    • Multiplex polymerase chain reaction detection enhancement of bacteremia and fungemia
    • Louie RF, Tang Z, Albertson TE, et al. Multiplex polymerase chain reaction detection enhancement of bacteremia and fungemia. Crit Care Med 2008; 36:1487-1492.
    • (2008) Crit Care Med , vol.36 , pp. 1487-1492
    • Louie, R.F.1    Tang, Z.2    Albertson, T.E.3
  • 24
    • 43049121061 scopus 로고    scopus 로고
    • Molecular diagnosis of sepsis in neutropenic patients with haematological malignancies
    • Mancini N, Clerici D, Diotti R, et al. Molecular diagnosis of sepsis in neutropenic patients with haematological malignancies. J Med Microbiol 2008; 57:601-604.
    • (2008) J Med Microbiol , vol.57 , pp. 601-604
    • Mancini, N.1    Clerici, D.2    Diotti, R.3
  • 25
    • 73949106830 scopus 로고    scopus 로고
    • Multiplex PCR to diagnose bloodstream infections in patients admitted from the emergency department with sepsis
    • Tsalik EL, Jones D, Nicholson B, et al. Multiplex PCR to diagnose bloodstream infections in patients admitted from the emergency department with sepsis. J Clin Microbiol 2010; 48:26-33.
    • (2010) J Clin Microbiol , vol.48 , pp. 26-33
    • Tsalik, E.L.1    Jones, D.2    Nicholson, B.3
  • 26
    • 33745620019 scopus 로고    scopus 로고
    • Evaluation of rapid screening and preemptive contact isolation for detecting and controlling methicillin-resistant Staphylococcus aureus in critical care: An interventional cohort study
    • Harbarth S, Masuet-Aumatell C, Schrenzel J, et al. Evaluation of rapid screening and preemptive contact isolation for detecting and controlling methicillin-resistant Staphylococcus aureus in critical care: an interventional cohort study. Crit Care 2006; 10:R25.
    • (2006) Crit Care , vol.10
    • Harbarth, S.1    Masuet-Aumatell, C.2    Schrenzel, J.3
  • 27
    • 0036304245 scopus 로고    scopus 로고
    • Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia
    • Iregui M, Ward S, Sherman G, et al. Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest 2002; 122:262-268.
    • (2002) Chest , vol.122 , pp. 262-268
    • Iregui, M.1    Ward, S.2    Sherman, G.3
  • 28
    • 12844281083 scopus 로고    scopus 로고
    • Bloodstream infections: A trial of the impact of different methods of reporting positive blood culture results
    • Bouza E, Sousa D, Munoz P, et al. Bloodstream infections: a trial of the impact of different methods of reporting positive blood culture results. Clin Infect Dis 2004; 39:1161-1169.
    • (2004) Clin Infect Dis , vol.39 , pp. 1161-1169
    • Bouza, E.1    Sousa, D.2    Munoz, P.3
  • 32
    • 0037123196 scopus 로고    scopus 로고
    • Bio-barcodes based onoligonucleotide-modified nanoparticles
    • Nam JM, ParkSJ, MirkinCA. Bio-barcodes based onoligonucleotide-modified nanoparticles. J Am Chem Soc 2002; 124:3820-3821.
    • (2002) J Am Chem Soc , vol.124 , pp. 3820-3821
    • Nam, J.M.1    Park, S.J.2    Mirkin, C.A.3
  • 33
    • 2442575025 scopus 로고    scopus 로고
    • Bio-bar-code-based DNA detection with PCR-like sensitivity
    • Nam JM, Stoeva SI, Mirkin CA. Bio-bar-code-based DNA detection with PCR-like sensitivity. J Am Chem Soc 2004; 126:5932-5933.
    • (2004) J Am Chem Soc , vol.126 , pp. 5932-5933
    • Nam, J.M.1    Stoeva, S.I.2    Mirkin, C.A.3
  • 34
    • 0037154825 scopus 로고    scopus 로고
    • Array-based electrical detection of DNA with nanoparticle probes
    • Park SJ, Taton TA, Mirkin CA. Array-based electrical detection of DNA with nanoparticle probes. Science 2002; 295:1503-1506.
    • (2002) Science , vol.295 , pp. 1503-1506
    • Park, S.J.1    Taton, T.A.2    Mirkin, C.A.3
  • 35
    • 84925571176 scopus 로고    scopus 로고
    • The proof of B-Streptococcus in comparison: Culture (Goldstandard) versus GeneXpert GBS (PCR-Schnellt-est)
    • Kersten DJ, Henle-Gross A, Droz S, et al. The proof of B-Streptococcus in comparison: culture (Goldstandard) versus GeneXpert GBS (PCR-Schnellt-est). Geburtsh Frauenheilk 2008; 68:S126.
    • (2008) Geburtsh Frauenheilk , vol.68
    • Kersten, D.J.1    Henle-Gross, A.2    Droz, S.3
  • 36
    • 66149115670 scopus 로고    scopus 로고
    • Identification of methicillin-resistant or methicillin-susceptible Staphylococcus aureus in blood cultures and wound swabs by GeneXpert
    • Parta M, Goebel M, Matloobi M, et al. Identification of methicillin-resistant or methicillin-susceptible Staphylococcus aureus in blood cultures and wound swabs by GeneXpert. J Clin Microbiol 2009; 47:1609-1610.
    • (2009) J Clin Microbiol , vol.47 , pp. 1609-1610
    • Parta, M.1    Goebel, M.2    Matloobi, M.3
  • 37
    • 77954882670 scopus 로고    scopus 로고
    • Cepheid granted US patent covering GeneXpert (R) cartridge: Key patent enables fully automated sample preparation for DNA testing
    • Anonymous
    • Anonymous. Cepheid granted US patent covering GeneXpert (R) cartridge: key patent enables fully automated sample preparation for DNA testing. Mol Biotechnol 2002; 22:213-214.
    • (2002) Mol Biotechnol , vol.22 , pp. 213-214
  • 38
    • 70349972114 scopus 로고    scopus 로고
    • Point-of-care testing and molecular diagnostics: Miniaturization required
    • Kiechle FL, Holland CA. Point-of-care testing and molecular diagnostics: miniaturization required. Clin Lab Med 2009; 29:555.
    • (2009) Clin Lab Med , vol.29 , pp. 555
    • Kiechle, F.L.1    Holland, C.A.2
  • 40
    • 1542614140 scopus 로고    scopus 로고
    • Nucleic acid purification using microfabricated silicon structures
    • Cady NC, Stelick S, Batt CA. Nucleic acid purification using microfabricated silicon structures. Biosens Bioelectron 2003; 19:59-66.
    • (2003) Biosens Bioelectron , vol.19 , pp. 59-66
    • Cady, N.C.1    Stelick, S.2    Batt, C.A.3
  • 41
    • 12444313592 scopus 로고    scopus 로고
    • Microchip-based purification of DNA from biological samples
    • Breadmore MC, Wolfe KA, Arcibal IG, et al. Microchip-based purification of DNA from biological samples. Anal Chem 2003; 75:1880-1886.
    • (2003) Anal Chem , vol.75 , pp. 1880-1886
    • Breadmore, M.C.1    Wolfe, K.A.2    Arcibal, I.G.3
  • 42
    • 65349186471 scopus 로고    scopus 로고
    • Cutting edge: Microfluidic-micromagnetic blood cleansing device
    • Lee AP. Cutting edge: microfluidic-micromagnetic blood cleansing device. Lab Chip 2009; 9:1167.
    • (2009) Lab Chip , vol.9 , pp. 1167
    • Lee, A.P.1
  • 43
    • 65349174488 scopus 로고    scopus 로고
    • Micromagnetic-microfluidic blood cleansing device
    • Yung CW, Fiering J, Mueller AJ, Ingber DE. Micromagnetic-microfluidic blood cleansing device. Lab Chip 2009; 9:1171-1177.
    • (2009) Lab Chip , vol.9 , pp. 1171-1177
    • Yung, C.W.1    Fiering, J.2    Mueller, A.J.3    Ingber, D.E.4
  • 44
    • 0036120419 scopus 로고    scopus 로고
    • Lipooligosaccharide and polysac-charide capsule: Virulence factors of Neisseria meningitidis that determine meningococcal interaction with human dendritic cells
    • Unkmeir A, Kammerer U, Stade A, et al. Lipooligosaccharide and polysac-charide capsule: virulence factors of Neisseria meningitidis that determine meningococcal interaction with human dendritic cells. Infect Immun 2002; 70:2454-2462.
    • (2002) Infect Immun , vol.70 , pp. 2454-2462
    • Unkmeir, A.1    Kammerer, U.2    Stade, A.3
  • 45
    • 0021964174 scopus 로고
    • The relative role of bacterial-cell wall and capsule in the induction of inflammation in pneumococcal meningitis
    • Tuomanen E, Tomasz A, Hengstler B, Zak O. The relative role of bacterial-cell wall and capsule in the induction of inflammation in pneumococcal meningitis. J Infect Dis 1985; 151:535-540.
    • (1985) J Infect Dis , vol.151 , pp. 535-540
    • Tuomanen, E.1    Tomasz, A.2    Hengstler, B.3    Zak, O.4
  • 46
    • 33646912788 scopus 로고    scopus 로고
    • Why human platelets fail to kill bacteria
    • White JG. Why human platelets fail to kill bacteria. Platelets 2006; 17:191-200.
    • (2006) Platelets , vol.17 , pp. 191-200
    • White, J.G.1
  • 47
    • 0015152169 scopus 로고
    • Platelet interaction with bacteria II. Fate of bacteria
    • Clawson CC, White JG. Platelet interaction with bacteria II. Fate of bacteria. Am J Pathol 1971; 65:381.
    • (1971) Am J Pathol , vol.65 , pp. 381
    • Clawson, C.C.1    White, J.G.2
  • 48
    • 33646854563 scopus 로고    scopus 로고
    • The interaction of bacterial pathogens with platelets
    • Fitzgerald JR, Foster TJ, Cox D. The interaction of bacterial pathogens with platelets. Nat Rev Microbiol 2006; 4:445-457.
    • (2006) Nat Rev Microbiol , vol.4 , pp. 445-457
    • Fitzgerald, J.R.1    Foster, T.J.2    Cox, D.3


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