Structural basis for hydration dynamics in radical stabilization of bilin reductase mutants

Biochemistry

Volumn 49, Issue 29, 2010, Pages 6206-6218

  Kohler, Amanda C ^a   Gae, David D ^a   Richley, Michael A ^a   Stoll, Stefan ^a   Gunn, Alexander ^a   Lim, Sunghyuk ^a   Martin, Shelley S ^a   Doukov, Tzanko I ^b   Britt, R David ^a   Ames, James B ^a   Lagarias, J Clark ^a   Fisher, Andrew J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SLAC NATIONAL ACCELERATOR LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CATALYTIC MECHANISMS; CATALYTIC RESIDUE; CATALYTIC TURNOVER; CHROMOPHORE PRECURSORS; FOUR-ELECTRON REDUCTION; GAIN INSIGHT; HIGH RESOLUTION CRYSTAL STRUCTURE; HISTIDINE RESIDUES; HYDRATION DYNAMICS; INTERCONVERSIONS; KEY ENZYMES; LIGHT-HARVESTING; LINEAR TETRAPYRROLES; MECHANISTIC SCHEME; NEUTRAL RADICAL; NMR ANALYSIS; ONE-ELECTRON REDUCTIONS; OXIDOREDUCTASES; OXYGENIC PHOTOSYNTHETIC ORGANISMS; PHYCOBILIPROTEINS; PROTONATION STATE; SIDE CHAINS; STRUCTURAL BASIS; STRUCTURAL STUDIES; SYNECHOCYSTIS SP. PCC 6803; VINYL GROUP; WATER MOLECULE; WILD TYPES;

CHROMOPHORES; CRYSTAL STRUCTURE; ENZYMES; HYDRATION; PHOSPHATASES; PORPHYRINS; STABILIZATION;

MOLECULES;

BILIN REDUCTASE; MUTANT PROTEIN; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL METABOLISM; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ELECTRON SPIN RESONANCE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME STABILITY; ENZYME SUBSTRATE COMPLEX; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; HYDRATION; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; SYNECHOCYSTIS;

ASPARAGINE; BACTERIAL PROTEINS; BILE PIGMENTS; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HISTIDINE; MUTATION; OXIDOREDUCTASES; PHYCOBILINS; PHYCOCYANIN; PROTEIN CONFORMATION; WATER;

SYNECHOCYSTIS SP. PCC 6803;

EID: 77954837610     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100728q     Document Type: Article

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