Aprepitant vs. multimodal prophylaxis in the prevention of nausea and vomiting following extended-release epidural morphine

Pain Practice

Volumn 10, Issue 3, 2010, Pages 245-248

  Hartrick, Craig T ^a,b   Tang, Yeong Shiuh ^a   Hunstad, David ^a   Pappas, John ^a   Muir, Kathy ^a   Pestano, Cecile ^a   Silvasi, Daniel ^a  

^a WILLIAM BEAUMONT HOSPITAL   (United States)

^b OAKLAND UNIVERSITY   (United States)

Author keywords

Extended release epidural morphine; Multimodal anti emetic prophylaxis; Neurkinin 1 antagonist; PONV; Postoperative nausea and vomiting

Indexed keywords

APREPITANT; DEXAMETHASONE; DIPHENHYDRAMINE; KETOROLAC; METOCLOPRAMIDE; MORPHINE; MORPHINE SULFATE; ONDANSETRON; PROCHLORPERAZINE; ANTIEMETIC AGENT; MORPHOLINE DERIVATIVE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; FEMALE; HUMAN; INCIDENCE; MALE; MOTION SICKNESS; POSTOPERATIVE ANALGESIA; POSTOPERATIVE NAUSEA AND VOMITING; POSTOPERATIVE PAIN; PREOPERATIVE CARE; PROPHYLAXIS; PROSPECTIVE STUDY; QUALITY CONTROL; RISK FACTOR; SINGLE DRUG DOSE; SMOKING; TOTAL KNEE REPLACEMENT; CASE CONTROL STUDY; CHEMICALLY INDUCED; COMPLICATION; DRUG DELIVERY SYSTEM; EPIDURAL ANESTHESIA; MIDDLE AGED; NAUSEA; PAIN; PATHOPHYSIOLOGY; POSTOPERATIVE COMPLICATION; RETROSPECTIVE STUDY; RISK; VERY ELDERLY; VOMITING;

AGED; AGED, 80 AND OVER; ANESTHESIA, EPIDURAL; ANTIEMETICS; CASE-CONTROL STUDIES; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; MALE; MIDDLE AGED; MORPHINE; MORPHOLINES; NAUSEA; ODDS RATIO; PAIN; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; VOMITING;

EID: 77954836195     PISSN: 15307085     EISSN: 15332500     Source Type: Journal    
DOI: 10.1111/j.1533-2500.2010.00364.x     Document Type: Article

References (10)

1. Hartrick CT, Hartrick KA. Extended-release epidural morphine (DepoDur): review and safety analysis. Expert Rev Neurother. 2008, 8:1641-1648.
2. Diemunsch P, Apfel C, Gan TJ. Preventing postoperative nausea and vomiting: post hoc analysis of pooled data from two randomized active-controlled trials of aprepitant. Curr Med Res Opin. 2007, 23:2559-2565.
3. Apfel CC, Korttila K, Abdalla M. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. N Engl J Med. 2004, 350:2441-2451.
4. Pierre S, Corno G, Benais H, Apfel CC. A risk score-dependent antiemetic approach effectively reduces postoperative nausea and vomiting-a continuous quality improvement initiative. Can J Anesth. 2004, 51:320-325.
5. Apfel CC, Malhotra A, Leslie JB. The role of neurokinin-1 receptor antagonists for the management of postoperative nausea and vomiting. Curr Opin Anesthesiol. 2009, 21:427-432.
6. Apfel CC, Läärä E, Koivuranta M, Greim CA, Roewer N. A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers. Anesthesiology. 1999, 91:693-700.
7. Kovac AL. Meta-analysis of the use of rescue antiemetics following PONV prophylactic failure with 5-HT3 antagonist/dexamethasone versus single-agent therapies. Ann Pharmacother. 2006, 40:873-887.
8. White PF, O'Hara JF, Roberson CR, Wender RH, Candiotti KA. The impact of current antiemetic practices on patient outcomes: a prospective study on high-risk patients. Anesth Analg. 2008, 107:452-458.
9. Moerman DE. The meaning response: thinking about placebos. Pain Pract. 2006, 6:233-236.
10. Hartrick CT, Martin G, Kantor G, Koncelik J, Manvelian G. Evaluation of a single-dose, extended-release epidural morphine formulation for pain after knee arthroplasty. J Bone Joint Surg Am. 2006, 88:2535-2536.