The interplay of phase inversion, polymer membrane formation, and drug release in a membrane-based delivery system

Journal of Membrane Science

Volumn 358, Issue 1-2, 2010, Pages 85-92

  Xiang, Aishuang ^a   Ma, Decheng ^a   McHugh, Anthony J ^a  

^a Lehigh University   (United States)

Author keywords

Biodegradable; Controlled release; Drug delivery; Membrane; Phase inversion

Indexed keywords

AS-CAST; CASTING CONDITIONS; CONTROLLED RELEASE DRUGS; DELIVERY SYSTEMS; DENSE STRUCTURES; DRIED FILMS; DRUG LOADING; DRUG RELEASE; DRUG RELEASE KINETICS; DRUG-RELEASE RATE; GLASS COMPOSITIONS; IN-PROCESS; MEMBRANE FORMATION; N-BUTYL CYANOACRYLATE; NAPROXENS; NON-SOLVENTS; OPTIMAL COMPOSITION; PHASE INVERSION; PLASTICIZING EFFECTS; POLYMER MEMBRANE; POLYMER-SOLVENTS; POROUS MORPHOLOGY; POROUS STRUCTURES; SOLVENT CAST FILMS;

ACETONE; CRYSTALLIZATION KINETICS; DIFFERENTIAL SCANNING CALORIMETRY; FUNCTIONAL POLYMERS; GLASS; GLASS TRANSITION; MEMBRANES; MORPHOLOGY; PHASE DIAGRAMS; POLYMER FILMS; POLYMERS; SCANNING ELECTRON MICROSCOPY; SOLVENTS;

CONTROLLED DRUG DELIVERY;

ACETONE; ENBUCRILATE; NAPROXEN; POLYMER; SOLVENT; WATER;

ARTICLE; BIODEGRADABILITY; CHEMICAL COMPOSITION; CONTROLLED DRUG RELEASE; CRYSTALLIZATION; DENSITY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG RELEASE; ELECTRON MICROSCOPY; FILM; GLASS TRANSITION TEMPERATURE; KINETICS; MEMBRANE FORMATION; MORPHOLOGY; POLYMERIZATION; POROSITY; PRIORITY JOURNAL; STRUCTURE ANALYSIS; THERMAL ANALYSIS;

EID: 77954818816     PISSN: 03767388     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.memsci.2010.04.031     Document Type: Article

References (17)

1. Ahmed A., Barry B.W., Williams A.C., Davis A.F. Penciclovir solubility in Eudragit films: a comparison of X-ray, thermal, microscopic and release rate techniques. J. Pharm. Biomed. Anal. 2004, 34:945-956.
2. Alexis F., Venkatraman S.S., Rath S.K., Boey F. In vitro study of release mechanisms of paclitaxel and rapamycin from drug-incorporated biodegradable stent matrices. J. Control. Release 2004, 98:67-74.
3. Acharya G., Park K. Mechanisms of controlled drug release from drug-eluting stents. Adv. Drug Deliv. Rev. 2006, 58:387-401.
4. D. Ma, The interplay of drug, polymer, and solvent properties in the fabrication of membrane-based delivery systems, PhD dissertation, Lehigh University, 2008.
5. Ma D., McHugh A.J. The interplay of membrane formation and drug release in solution-cast films of polylactide polymers. Int. J. Pharm. 2010, 388:1-12.
6. Ma D., McHugh A.J. The interplay of phase inversion and membrane formation in the drug release characteristics of a membrane-based delivery system. J. Membr. Sci. 2007, 298:156-168.
7. S.H. Kessler, S.E. Mastroianni, Polymeric devices for controlled release, Research report, Lehigh University, 2008.
8. Cijvan S., Margetis P.M., Reddick R.L. Properties of n-butyl-a-cyanoacrylate mixtures. J. Dent. Res. 1969, 48:536-542.
9. Gulyaev A.E., Gelperina S.E., Skidan I.N., Antropov A.S., Kivman G.Y., Kreuter J. Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles. Pharm. Res. 1999, 16(10):1564-1569.
10. Ryan B., McCann G. Novel sub-ceiling temperature rapid depolymerization-repolymerization reactions of cyanoacrylate polymers. Macromol. Rapid Commun. 1996, 17:217-227.
11. Sullivan C.O., Birkinshaw C. In vitro degradation of insulin-loaded poly(n-butylcyanoacrylate) nanoparticles. Biomaterials 2004, 25:4375-4382.
12. Li J., Masso J.J., Guertin J.A. Prediction of drug solubility in an acrylate adhesive based on the drug-polymer interaction parameter and drug solubility in acetonitrile. J. Control. Release 2002, 83:211-221.
13. Nair R., Nyamweya N., GÖnen S., Martίnez-Miranda L.J., Hoag S.W. Influence of various drugs on the glass transition temperature of poly(vinylpyrrolidone): a thermodynamic and spectroscopic investigation. Int. J. Pharm. 2001, 225:83-96.
14. Hancock B.C., Zografi G. The relationship between the glass transition temperature and the water content of amorphous pharmaceutical solids. Pharm. Res. 1994, 11:471-477.
15. Yip Y., McHugh A.J. Modeling and simulation of nonsolvent vapor-induced phase separation. J. Membr. Sci. 2006, 271:163-176.
16. Johari G.P. Calorimetric features of high-enthalpy amorphous solids and glass-softening temperature of water. J. Phys. Chem. B 2003, 107:9063-9070.
17. Kelley F.N., Bueche F. Viscosity and glass temperature relations for polymer-diluent systems. J. Polym. Sci. 1961, 50:549-556.