메뉴 건너뛰기




Volumn 24, Issue 8, 2010, Pages 525-531

Comparison of the efficacy of candesartan and losartan: A meta-analysis of trials in the treatment of hypertension

Author keywords

angiotensin II type 1 receptor blockers; anti hypertensive treatment; benzimidazoles; candesartan; losartan; randomized controlled trials

Indexed keywords

CANDESARTAN; CANDESARTAN PLUS HYDROCHLOROTHIAZIDE; HYDROCHLOROTHIAZIDE; HYDROCHLOROTHIAZIDE PLUS LOSARTAN; LOSARTAN; UNCLASSIFIED DRUG; ANTIHYPERTENSIVE AGENT; BENZIMIDAZOLE DERIVATIVE; TETRAZOLE DERIVATIVE;

EID: 77954814946     PISSN: 09509240     EISSN: 14765527     Source Type: Journal    
DOI: 10.1038/jhh.2009.99     Document Type: Article
Times cited : (18)

References (32)
  • 1
    • 0025347391 scopus 로고
    • Blood pressure, stroke, and coronary heart disease: Part 2. Short-term reductions in blood pressure: Overview of randomised drug trials in their epidemiological context
    • Collins R, Peto R, MacMahon S, Hebert P, Fiebach NH, Eberlein KA et al. Blood pressure, stroke, and coronary heart disease: part 2. Short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet 1990; 335: 827-838.
    • (1990) Lancet , vol.335 , pp. 827-838
    • Collins, R.1    Peto, R.2    MacMahon, S.3    Hebert, P.4    Fiebach, N.H.5    Eberlein, K.A.6
  • 2
    • 44349101152 scopus 로고    scopus 로고
    • Blood pressure lowering treatment trialists' collaboration. Effects of different regimens to lower blood pressure on major cardiovascular events in older and younger adults: Meta-analysis of randomised trials
    • Blood Pressure Lowering Treatment Trialists' Collaboration. Effects of different regimens to lower blood pressure on major cardiovascular events in older and younger adults: meta-analysis of randomised trials. Br Med J 2008; 336: 1121-1123.
    • (2008) Br Med J , vol.336 , pp. 1121-1123
  • 4
    • 34250350040 scopus 로고    scopus 로고
    • 2007 guidelines for the management of arterial hypertension: The task force for the management of arterial hypertension of the european society of hypertension (ESH) and of the European Society of cardiology (ESC)
    • Management of arterial hypertension of the European society of hypertension. European society of cardiology
    • Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G et al. Management of Arterial Hypertension of the European Society of Hypertension. European Society of Cardiology. 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007; 25(6): 1105-1108.
    • (2007) J Hypertens , vol.25 , Issue.6 , pp. 1105-1108
    • Mancia, G.1    De Backer, G.2    Dominiczak, A.3    Cifkova, R.4    Fagard, R.5    Germano, G.6
  • 6
    • 0036429265 scopus 로고    scopus 로고
    • The relationships between dose and antihypertensive effect of four AT1-receptor blockers. Differences in potency and efficacy
    • Elmfeldt D, Olofsson B, Meredith P. The relationships between dose and antihypertensive effect of four AT1-receptor blockers. Differences in potency and efficacy. Blood Press 2002; 11: 293-301.
    • (2002) Blood Press , vol.11 , pp. 293-301
    • Elmfeldt, D.1    Olofsson, B.2    Meredith, P.3
  • 7
    • 0029932496 scopus 로고    scopus 로고
    • Losartan potassium: A review of its pharmacology, clinical efficacy, and tolerability in the management of hypertension
    • Goa KL, Wagstaff AJ. Losartan potassium: a review of its pharmacology, clinical efficacy, and tolerability in the management of hypertension. Drugs 1996; 51(5): 820-845.
    • (1996) Drugs , vol.51 , Issue.5 , pp. 820-845
    • Goa, K.L.1    Wagstaff, A.J.2
  • 8
    • 0036271824 scopus 로고    scopus 로고
    • Candesartan cilexetil: An update of its use in essential hypertension
    • Easthope SE, Jarvis B. Candesartan cilexetil: an update of its use in essential hypertension. Drugs 2002; 62(8): 1253-1287.
    • (2002) Drugs , vol.62 , Issue.8 , pp. 1253-1287
    • Easthope, S.E.1    Jarvis, B.2
  • 9
    • 33745579670 scopus 로고    scopus 로고
    • Long-lasting angiotensin type 1 receptor binding and protection by candesartan: Comparison with other biphenyl-tetrazole sartans
    • Vauquelin G, Fierens F, Van Liefde I. Long-lasting angiotensin type 1 receptor binding and protection by candesartan: comparison with other biphenyl-tetrazole sartans. JHypertens 2006; 24(1): S23-S30.
    • (2006) JHypertens , vol.24 , Issue.1
    • Vauquelin, G.1    Fierens, F.2    Van Liefde, I.3
  • 10
    • 0030698746 scopus 로고    scopus 로고
    • Inhibition of angiotensin II pressor response and ex vivo angiotensin II radioligand binding by candesartan cilexetil and losartan in healthy human volunteers
    • Belz GG, Fuchs B, Malerczyk C, Magin SG, Roll S, Mutschler E. Inhibition of angiotensin II pressor response and ex vivo angiotensin II radioligand binding by candesartan cilexetil and losartan in healthy human volunteers. J Hum Hypertens 1997; vfll(Suppl 2): S45-S47.
    • (1997) J Hum Hypertens , vol.VFLL , Issue.SUPPL. 2
    • Belz, G.G.1    Fuchs, B.2    Malerczyk, C.3    Magin, S.G.4    Roll, S.5    Mutschler, E.6
  • 11
    • 77954815763 scopus 로고    scopus 로고
    • Review Manager (RevMan). [Computer program]. Version 5.0 The Nordic Cochrane Centre, The Cochrane Collaboration: Copenhagen, 2008
    • Review Manager (RevMan). [Computer program]. Version 5.0 The Nordic Cochrane Centre, The Cochrane Collaboration: Copenhagen, 2008.
  • 13
    • 0031882729 scopus 로고    scopus 로고
    • The antihypertensive effect and tolerability of candesartan cilexetil, a new generation angiotensin II antagonist, in comparison with losartan
    • Andersson OK, Neldam S. The antihypertensive effect and tolerability of candesartan cilexetil, a new generation angiotensin II antagonist, in comparison with losartan. Blood Press 1998; 7: 53-59.
    • (1998) Blood Press , vol.7 , pp. 53-59
    • Andersson, O.K.1    Neldam, S.2
  • 14
    • 33645068586 scopus 로고    scopus 로고
    • A placebo-controlled comparison of the efficacy and tolerability of candesartan cilexetil, 8 mg, and losartan, 50 mg, as monotherapy in patients with essential hypertension, using 36-h ambulatory blood pressure monitoring
    • Baguet J-P, Nisse-Durgeat S, Mouret S, Asmar R, Mallion J-M. A placebo-controlled comparison of the efficacy and tolerability of candesartan cilexetil, 8 mg, and losartan, 50 mg, as monotherapy in patients with essential hypertension, using 36-h ambulatory blood pressure monitoring. Int J Clin Pract 2006; 60: 391-398.
    • (2006) Int J Clin Pract , vol.60 , pp. 391-398
    • Baguet, J.-P.1    Nisse-Durgeat, S.2    Mouret, S.3    Asmar, R.4    Mallion, J.-M.5
  • 15
    • 0034959207 scopus 로고    scopus 로고
    • Antihypertensive efficacy of candesartan in comparison to losartan: The CLAIM study
    • Bakris G, Gradman A, Reif M, Wofford M, Munger M, Harris S et al. Antihypertensive efficacy of candesartan in comparison to losartan: the CLAIM study. J Clin Hypertens 2001; 3: 16-21.
    • (2001) J Clin Hypertens , vol.3 , pp. 16-21
    • Bakris, G.1    Gradman, A.2    Reif, M.3    Wofford, M.4    Munger, M.5    Harris, S.6
  • 16
    • 0033123506 scopus 로고    scopus 로고
    • Comparative effects of candesartan cilexetil and losartan in patients with systemic hypertension
    • Candesartan Versus Losartan Efficacy Comparison (CANDLE) Study Group
    • Gradman AH, Lewin A, Bowling BT, Tonkon M, Deedwania PC, Kezer AE et al. Comparative effects of candesartan cilexetil and losartan in patients with systemic hypertension. Candesartan Versus Losartan Efficacy Comparison (CANDLE) Study Group. Heart Dis 1999; 1: 52-57.
    • (1999) Heart Dis , vol.1 , pp. 52-57
    • Gradman, A.H.1    Lewin, A.2    Bowling, B.T.3    Tonkon, M.4    Deedwania, P.C.5    Kezer, A.E.6
  • 17
    • 0034006111 scopus 로고    scopus 로고
    • Comparison of the efficacy and tolerability of combination tablets containing candesartan cilexetil and hydrochlorothiazide or losartan and hydrochlor-othiazide in patients with moderate to severe hypertension. Results of the CARLOS-Study
    • Koenig W. Comparison of the efficacy and tolerability of combination tablets containing candesartan cilexetil and hydrochlorothiazide or losartan and hydrochlor-othiazide in patients with moderate to severe hypertension. Results of the CARLOS-Study. Clin Drug Investig 2000; 19: 239-246.
    • (2000) Clin Drug Investig , vol.19 , pp. 239-246
    • Koenig, W.1
  • 18
    • 2542479913 scopus 로고    scopus 로고
    • Comparison of effects of losartan, irbesartan, and candesartan on flow-mediated brachial artery dilation and on inflammatory and thrombolytic markers in patients with systemic hypertension
    • Koh KK, Han SH, Chung WJ, Ahn JY, Jin DK, Kim HS et al. Comparison of effects of losartan, irbesartan, and candesartan on flow-mediated brachial artery dilation and on inflammatory and thrombolytic markers in patients with systemic hypertension. Am J Cardiol 2004; 93: 1432-1435.
    • (2004) Am J Cardiol , vol.93 , pp. 1432-1435
    • Koh, K.K.1    Han, S.H.2    Chung, W.J.3    Ahn, J.Y.4    Jin, D.K.5    Kim, H.S.6
  • 19
    • 0033391893 scopus 로고    scopus 로고
    • A comparison of the efficacy and duration of action of candesartan cilexetil and losartan as assessed by clinic and ambulatory blood pressure after a missed dose, in truly hypertensive patients: A placebo-controlled, forced titration study. Candesartan/Losartan study investigators
    • Lacourciere Y, Asmar R. A comparison of the efficacy and duration of action of candesartan cilexetil and losartan as assessed by clinic and ambulatory blood pressure after a missed dose, in truly hypertensive patients: a placebo-controlled, forced titration study. Candesartan/Losartan study investigators. Am J Hy- pertens 1999; 12: 1181-1187.
    • (1999) Am J Hy- Pertens , vol.12 , pp. 1181-1187
    • Lacourciere, Y.1    Asmar, R.2
  • 20
    • 0033746050 scopus 로고    scopus 로고
    • Effects of losartan and candesartan monotherapy and losartan/hydrochlor- othiazide combination therapy in patients with mild to moderate hypertension Losartan Trial Investigators
    • Manolis AJ, Grossman E, Jelakovic B, Jacovides A, Bernhardi DC, Cabrera WJ et al. Effects of losartan and candesartan monotherapy and losartan/hydrochlor-othiazide combination therapy in patients with mild to moderate hypertension Losartan Trial Investigators. Clin Ther 2000; 22: 1186-1203.
    • (2000) Clin Ther , vol.22 , pp. 1186-1203
    • Manolis, A.J.1    Grossman, E.2    Jelakovic, B.3    Jacovides, A.4    Bernhardi, D.C.5    Cabrera, W.J.6
  • 22
    • 23844494098 scopus 로고    scopus 로고
    • Efficacy and duration of action of the four selective angiotensin II subtype 1 receptor blockers, losartan, candesartan, valsartan and telmisartan, in patients with essential hypertension determined by home blood pressure measurements
    • Nishimura T, Hashimoto J, Ohkubo T, Kikuya M, Metoki H, Asayama K et al. Efficacy and duration of action of the four selective angiotensin II subtype 1 receptor blockers, losartan, candesartan, valsartan and telmisartan, in patients with essential hypertension determined by home blood pressure measurements. Clin Exp Hypertens 2005; 27: 477-489.
    • (2005) Clin Exp Hypertens , vol.27 , pp. 477-489
    • Nishimura, T.1    Hashimoto, J.2    Ohkubo, T.3    Kikuya, M.4    Metoki, H.5    Asayama, K.6
  • 23
    • 0033803617 scopus 로고    scopus 로고
    • Efficacy and toler-ability of a combination tablet of candesartan cilexetil and hydrochlorothiazide in insufficiently controlled primary hypertension-comparison with a combination of losartan and hydrochlorothiazide
    • Ohman KP, Milon H, Valnes K. Efficacy and toler-ability of a combination tablet of candesartan cilexetil and hydrochlorothiazide in insufficiently controlled primary hypertension-comparison with a combination of losartan and hydrochlorothiazide. Blood Press 2000; 9: 214-220.
    • (2000) Blood Press , vol.9 , pp. 214-220
    • Ohman, K.P.1    Milon, H.2    Valnes, K.3
  • 24
    • 33644815752 scopus 로고    scopus 로고
    • Effect of losartan versus candesartan on uric acid, renal function, and fibrinogen in patients with hypertension and hyperuricemia associated with diuretics
    • Rayner BL, Trinder YA, Baines D, Isaacs S, Opie LH. Effect of losartan versus candesartan on uric acid, renal function, and fibrinogen in patients with hypertension and hyperuricemia associated with diuretics. Am J Hypertens 2006; 19: 208-213.
    • (2006) Am J Hypertens , vol.19 , pp. 208-213
    • Rayner, B.L.1    Trinder, Y.A.2    Baines, D.3    Isaacs, S.4    Opie, L.H.5
  • 25
    • 0034932549 scopus 로고    scopus 로고
    • A forced titration study of antihyper-tensive efficacy of candesartan cilexetil in comparison to losartan: CLAIM Study II
    • Vidt DG, White WB, Ridley E, Rahman M, Harris S, Vendetti J et al. A forced titration study of antihyper-tensive efficacy of candesartan cilexetil in comparison to losartan: CLAIM Study II. J Hum Hypertens 2001; 15: 475-480.
    • (2001) J Hum Hypertens , vol.15 , pp. 475-480
    • Vidt, D.G.1    White, W.B.2    Ridley, E.3    Rahman, M.4    Harris, S.5    Vendetti, J.6
  • 26
    • 0037079309 scopus 로고    scopus 로고
    • Age-specific relevance of usual blood pressure to vascular mortality: A meta-analysis of individual data for one million adults in 61 prospective studies
    • Prospective Studies Collaboration
    • Prospective Studies Collaboration. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002; 360: 1903-1913.
    • (2002) Lancet , vol.360 , pp. 1903-1913
  • 27
    • 67650082354 scopus 로고    scopus 로고
    • Use of blood pressure lowering drugs in the prevention of cardiovascular disease: Meta-analysis of 147 randomised trials in the context of expectations from prospective epidemio-logical studies
    • Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemio-logical studies. Br Med J 2009; 338: b1665.
    • (2009) Br Med J , vol.338
    • Law, M.R.1    Morris, J.K.2    Wald, N.J.3
  • 28
    • 61649091385 scopus 로고    scopus 로고
    • Combination therapy versus monotherapy in reducing blood pressure: Meta-analysis on 11 000 participants from 42 trials
    • Wald DS, Law M, Morris JK, Bestwick JP, Wald NJ. Combination therapy versus monotherapy in reducing blood pressure: meta-analysis on 11 000 participants from 42 trials. Am JMed 2009; 122: 290-300.
    • (2009) Am JMed , vol.122 , pp. 290-300
    • Wald, D.S.1    Law, M.2    Morris, J.K.3    Bestwick, J.P.4    Wald, N.J.5
  • 30
    • 0037534905 scopus 로고    scopus 로고
    • The study on cognition and prognosis in the elderly (SCOPE): Principal results of a randomized double-blind intervention trial
    • DOI 10.1097/00004872-200305000-00011
    • Lithell H, Hansson L, Skoog I, Elmfeldt D, Hofman A, Olofsson B et al. The Study On Cognition And Prognosis In The Elderly (SCOPE): principal results of a randomized double-blind intervention trial. J Hypertens 2003; 21: 875-886. (Pubitemid 36677151)
    • (2003) Journal of Hypertension , vol.21 , Issue.5 , pp. 875-886
    • Lithell, H.1    Hansson, L.2    Skoog, I.3    Elmfeldt, D.4    Hofman, A.5    Olofsson, B.6    Trenkwalder, P.7    Zanchetti, A.8
  • 32
    • 77949875945 scopus 로고    scopus 로고
    • Effects of losartan vs candesartan in reducing cardiovascular events in the primary treatment of hypertension
    • Kjeldsen SE, Stalhammar J, Hasvold P, Bodegard J, Olsson U, Russell D et al. Effects of losartan vs candesartan in reducing cardiovascular events in the primary treatment of hypertension. J Hum Hypertens 2010; 24: 263-273.
    • J Hum Hypertens , vol.2010 , Issue.24 , pp. 263-273
    • Kjeldsen, S.E.1    Stalhammar, J.2    Hasvold, P.3    Bodegard, J.4    Olsson, U.5    Russell, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.