Cerebrospinal fluid changes in the excitatory amino acids concentration caused by the standard treatment of acute lymphoblastic leukaemia in children do not correlate with their later cognitive functioning

Neuropediatrics

Volumn 40, Issue 6, 2009, Pages 295-297

  Protas, P T ^a   Muszynska Roslan, K ^a   Holownia, A ^a   Grabowska, A ^a   Krawczuk Rybak, M ^a   Braszko, J J ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

acute lymphoblastic leukaemia; aspartic acid; cognitive functioning; glutamic acid; neurotoxicity

Indexed keywords

ASPARAGINASE; ASPARTIC ACID; CYCLOPHOSPHAMIDE; CYTARABINE; DAUNORUBICIN; DEXAMETHASONE; DOXORUBICIN; EXCITATORY AMINO ACID; FOLINIC ACID; GLUTAMIC ACID; MERCAPTOPURINE; METHOTREXATE; PREDNISONE; TIOGUANINE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; CEREBROSPINAL FLUID; CHILD; CLINICAL ARTICLE; COGNITION; COGNITIVE BEHAVIORAL STRESS MANAGEMENT; CONTROLLED STUDY; FEMALE; HUMAN; MALE; NEUROTOXICITY; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD;

ADOLESCENT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHILD; CHILD, PRESCHOOL; COGNITION; EXCITATORY AMINO ACIDS; FEMALE; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA;

EID: 77954804122     PISSN: 0174304X     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0030-1249655     Document Type: Article

References (22)

1. Atlante A, Calissano P, Bobba A, etal. Glutamate neurotoxicity, oxidative stress and mitochondria. FEBS Lett 2001 18 1-5
2. Buizer AI, de Sonneville LM, Veerman AJ. Effects of chemotherapy on neurocognitive function in children with acute lymphoblastic leukemia: a critical review of the literature. Pediatr Blood Cancer 2009 52 447-454
3. Cole PD, Kamen BA. Delayed neurotoxicity associated with therapy for children with acute lymphoblastic leukemia. Ment Retard Dev Disabil Res Rev 2006 12 174-183
4. Cole PD, Beckwith KA, Vijayanathan V, etal. Folate homeostasis in cerebrospinal fluid during therapy for acute lymphoblastic leukemia. Pediatr Neurol 2009 1 34-41
5. Cronstein BN. The mechanism of action of methotrexate. Rheum Dis Clin North Am 1997 23 739-755
6. De Braganca KC, Packer RJ. Neurotoxicity of chemotherapeutic and biologic agents in children with cancer. Curr Neurol Neurosci Rep 2008 8 114-122
7. Glover DA, Byrne J, Mills JL, etal. Impact of CNS treatment on mood in adult survivors of childhood leukemia: a report from the Children's Cancer Group. J Clin Oncol 2003 21 4395-4401
8. Hallbk H, Gustafsson G, Smedmyr B, etal. Treatment outcome in young adults and children >10 years of age with acute lymphoblastic leukemia in Sweden: a comparison between a pediatric protocol and an adult protocol. Cancer 2006 107 1551-1561
9. Hill JM, Kornblith AB, Jones D, etal. A comparative study of the long term psychosocial functioning of childhood acute lymphoblastic leukemia survivors treated by intrathecal methotrexate with or without cranial radiation. Cancer 1998 82 208-218
10. Holownia A, Trofimiuk E, Krawczuk-Rybak M, etal. Cerebrospinal fluid excitatory amino acids and tau protein in children with acute lymphoblastic leukemia treated according to the BFM protocol. Acta Haematol 2004 112 222-224
11. Iuvone L, Mariotti P, Colosimo C, etal. Long-term cognitive outcome, brain computed tomography scan, and magnetic resonance imaging in children cured for acute lymphoblastic leukemia. Cancer 2002 95 2562-2570
12. Kingma A, van Dommelen RI, Mooyaart EL, etal. Slight cognitive impairment and magnetic resonance imaging abnormalities but normal school levels in children treated for acute lymphoblastic leukemia with chemotherapy only. J Pediatr 2001 139 413-420
13. Melucci D, Xie M, Reschiglian P, etal. FMOC-Cl as derivatizing agent for the analysis of amino acids and dipeptides by the absolute analysis method. Chromatographia 1999 5-6 317-320
14. Muszyñska-Rosan K, Krawczuk-Rybak M, Protas PT, etal. Level of tau protein in children treated for acute lymphoblastic leukemia. Pediatr Neurol 2006 34 367-371
15. Pui CH, Howard SC. Current management and challenges of malignant disease in the CNS in paediatric leukaemia. Lancet Oncol 2008 9 257-268
16. Pui CH, Robison LL, Look AT. Acute lymphoblastic leukaemia. Lancet 2008 22 1030-1043
17. Quinn CT, Griener JC, Bottiglieri T, etal. Elevation of homocysteine and excitatory amino acid neurotransmitters in the CSF of children who receive methotrexate for the treatment of cancer. J Clin Oncol 1997 15 2800-2806
18. Quinn CT, Griener JC, Bottiglieri T, etal. Effects of intraventricular methotrexate on folate, adenosine, and homocysteine metabolism in cerebrospinal fluid. J Pediatr Hematol Oncol 2004 26 386-388
19. Rainesalo S, Kernen T, Palmio J, etal. Plasma and cerebrospinal fluid amino acids in epileptic patients. Neurochem Res 2004 29 319-324
20. Shen EY, Lai YJ, Ho CS, etal. Excitatory and inhibitory amino acid levels in the cerebrospinal fluids of children with neurological disorders. Acta Paediatr Taiwan 1999 40 65-69
21. Virgin CE Jr, Ha TP, Packan DR, etal. Glucocorticoids inhibit glucose transport and glutamate uptake in hippocampal astrocytes: implications for glucocorticoid neurotoxicity. J Neurochem 1991 57 1422-1428
22. Zhang H, Zhang X, Zhang T, etal. Excitatory amino acids in cerebrospinal fluid of patients with acute head injuries. Clin Chem 2001 47 1458-1462