Plasma and Cerebrospinal Fluid Amino Acids in Epileptic Patients

Neurochemical Research

Volumn 29, Issue 1, 2004, Pages 319-324

  Rainesalo, Sirpa ^a,b   Keränen, Tapani ^a,c   Palmio, Johanna ^b   Peltola, Jukka ^b   Oja, Simo ^a,b   Saransaari, Pirjo ^a  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

Author keywords

Amino acids; Blood plasma; Cerebrospinal fluid; Epilepsy

Indexed keywords

AMINO ACID; ASPARTIC ACID; GLUTAMIC ACID; ORNITHINE; PHENYLALANINE; TAURINE;

ADOLESCENT; ADULT; AMINO ACID BLOOD LEVEL; AMINO ACID COMPOSITION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; FEMALE; GENERALIZED EPILEPSY; HUMAN; MALE; MYOCLONUS EPILEPSY; NEUROTRANSMITTER RELEASE; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; SEIZURE;

ADULT; AMINO ACIDS; EPILEPSY; FEMALE; HUMANS; MALE; MIDDLE AGED;

EID: 0842322717     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:NERE.0000010461.34920.0c     Document Type: Article

References (40)

1. During, M. J. and Spencer, D. D. 1993. Extracellular hippocampal glutamate and spontaneous seizures in the conscious human brain. Lancet 341:1607-1610.
2. Wilson, C. L., Maidment, N. T., Shomer, M. H., Behnke, E. J., Ackerson, L., Fried, I., and Engel, J. Jr. 1996. Comparison of seizure related amino acid release in human epileptic hippocampal versus chronic, kainate rat model of hippocampal epilepsy. Epilepsy Res. 26:245-254.
3. Mutani, R., Monaco, F., Durelli, L., and Delsedime, M. 1974. Free amino acids in the cerebrospinal fluid of epileptic subjects. Epilepsia 15:593-597.
4. Plum, C. M. 1974. Free amino acid levels in the cerebrospinal fluid of normal humans and their variation in cases of epilepsy and Spielmeyer-Vogt-Batten disease. J. Neurochem. 23:595-600.
5. Wood, J. H., Hare, T. A., Glaeser, B. S., Ballenger, J. C., and Post, R. M. 1979. Low cerebrospinal fluid γ-aminobutyric acid content in seizure patients. Neurology 29:1203-1208.
6. Engelsen, B. and ElSayed, S. 1984. Increased concentrations of aspartic acid in the cerebrospinal fluid of patients with epilepsy and trigeminal neuralgia: An effect of medication? Acta Neurol. Scand. 69:70-76.
7. Crawford, P. M. and Chadwick, D. W. 1987. GABA and amino acid concentrations in lumbar CSF in patients with treated and untreated epilepsy. Epilepsy Res. 1:328-338.
8. Pitkänen, A., Riekkinen, P. J., Halonen, T., Ylinen, A., Ruutiainen, T., and Lehtinen, M. 1987. Amino acid levels in human CSF after generalized seizure. J. Neural Transm. 70:313-319.
9. Araki, K., Harada, M., Ueda, Y., Takino, T., and Kuriyama, K. 1988. Alteration of amino acid content of cerebrospinal fluid from patients with epilepsy. Acta Neurol. Scand. 78:473-479.
10. Devinsky, O., Emoto, S., Nadi, N. S., and Theodore W. H. 1993. Cerebrospinal fluid levels of neuropeptides, cortisol, and amino acids in patients with epilepsy. Epilepsia 34:255-261.
11. Kälviäinen, R., Halonen, T., Pitkänen, A., and Riekkinen, P. J., 1993. Amino acid levels in the cerebrospinal fluid of newly diagnosed epileptic patients: Effect of vigabatrin and carbamazepine monotherapies. J. Neurochem. 60:1244-1250.
12. Monaco, F., Mutani, R., Durelli, L., and Delsedime, M. 1975. Free amino acids in serum of patients with epilepsy: Significant increase in taurine. Epilepsia 16:245-249.
13. Van Gelder, N. M., Janhua, N. A., Metrakos, K., MacGibbon, B., and Metrakos, J. D. 1980. Plasma amino acids in 3/s spike wave epilepsy. Neurochem. Res. 5:659-671.
14. Huxtable, R. J., Laird, H., Lippincott, S. E., and Walson, P. 1983. Epilepsy and the concentrations of plasma amino acids in humans. Neurochem. Int. 5:125-135.
15. Haines, J. L., Rich, S. S., Tsai, M. Y., and Anderson, I. E. 1985. Altered amino acid levels in multiply affected sibships with seizures. Epilepsia 26:642-648.
16. Janhua, N. A., Itano, T., Kugoh, T., Hosokawa, K., Nakano, M., Matsui, H., and Hatase, O. 1992. Familial increase in plasma glutamic acid in epilepsy. Epilepsy Res. 11:37-44.
17. Ferrie, C. D., Bird, S., Tilling, K., Maisey, M. N., Chapman, A. G., and Robinson, R. O. 1999. Plasma amino acids in childhood epileptic encephalopathies. Epilepsy Res. 34:221-229.
18. Rao, M. L., Stefan, H., Scheid, C., Kuttler, A. D. S., and Fröscher, W. 1993. Serum amino acids, liver status, and antiepileptic drug therapy in epilepsy. Epilepsia 34:347-354.
19. Lowry, O. H., Rosenbrough, N. J., Farr, A. L., and Randall, R. J. 1951. Protein measurements with the folin phenol reagent. J. Biol. Chem. 193:265-275.
20. Arroyo, S., Brodie, M. J., Avanzini, G., Baumgartner, C., Chiron, C., Dulac, O., French, J. A., and Serratosa, J. M. 2002. Is refractory epilepsy preventable? Epilepsia 43:437-444.
21. Rainesalo, S., Keränen, T., Peltola, J., and Saransaari, P. 2003. Glutamate uptake in blood platelets from epileptic patients. Neurochem. Int. 43:389-392.
22. Rainesalo, S., Saransaari, P., Peltola, J., and Keränen, T. 2003. Uptake of GABA and activity of GABA-transaminase in platelets from epileptic patients. Epilepsy Res. 53:233-239.
23. Millan, M. H., Chapman, A. G., and Meldrum, B. S. 1993. Extracellular amino acid levels in hippocampus during pilocarpine-induced seizures. Epilepsy Res. 14:139-148.
24. Liu, Z., Stafstrom, C. E., Sarkisian, M. R., Yang, Y., Hori, A., Tandon, P., and Holmes, G. L. 1997. Seizure-induced glutamate release in mature and immature animals: An in vivo microdialysis study. Neuroreport 27:2019-1023.
25. Pitkänen, A., Matilainen, R., Halonen, T., Kutvonen, R., Hartikainen, P., and Riekkinen, P. 1989. Inhibitory and excitatory amino acids in cerebrospinal fluid of chronic epileptic patients. J. Neural Transm. 76:221-230.
26. Pasantes-Morales, H., Quesada, O., and Moran, J. 1998. Taurine: An osmolyte in mammalian tissues. Adv. Exp. Med. Biol. 442: 209-217.
27. Chadwick, D., Hallett, M., Harris, R., Jenner, P., Reynolds, E. H., and Marsden, C. D. 1977. Clinical, biochemical, and physiological features distinguishing myoclonus responsive to 5-hydroxytryptophan, tryptophan with a monoamine oxidase inhibitor, and clonazepam. Brain 100:455-487.
28. Van Woert, M. H., Rosenbaum, D., Howieson, J., and Bowers, M. B. Jr. 1977. Long-term therapy of myoclonus and other neurologic disorders with L-5-hydroxytryptophan and carbidopa. New Engl. J. Med. 296:70-75.
29. Leino, E., MacDonald, E., Airaksinen, M. M., and Riekkinen, P. J. 1980. Homovanillic acid and 5-hydroxyindoleacetic acid levels in cerebrospinal fluid of patients with progressive myoclonus epilepsy. Acta Neurol. Scand. 62:41-54.
30. Leino, E., MacDonald, E., Airaksinen, M. M., Riekkinen, P. J., and Salo, H. 1982. L-Tryptophan-carbidopa trial in patients with long-standing progressive myoclonus epilepsy. Acta Neurol. Scand. 64:1321-1341.
31. Pitkänen, H., Mero, A., Oja, S. S., Komi, P. V., Rusko, H., Nummela, A., Saransaari, P., and Takala, T. 2002. Effects of training on the exercise-induced changes in serum amino acids and hormones. J. Strength Condit. Res. 16:390-398.
32. Del Prato, S., DeFronzo, R. A., Castellino, P., Wahren, J., and Alvestrand, A. 1990. Regulation of amino acid metabolism by epinephrine. Am. J. Physiol. 258:E878-E887.
33. Hammarqvist, F., Ejesson, B., and Wernerman, J. 2001. Stress hormones initiate prolonged changes in the muscle amino acid pattern. Clin. Physiol. 21:44-50.
34. Castillo, J., Dávalos, A., Naveiro, J., and Noya, M. 1996. Neuroexcitatory amino acids and their relation to infarct size and neurological deficit in ischemic stroke. Stroke 27:1060-1065.
35. Ferrarese, C., Aliprandi, A., Tremolizzo, L., Stanzani, L., De Micheli, A., Dolara, A., and Frattola, L. 2001. Increased glutamate in CSF and plasma of patients with HIV dementia. Neurology 57: 671-675.
36. Similä, S., von Wendt, L., and Linna, S. L. 1980. Dipropylacetate and aminoaciduria. J. Neurol. Sci. 45:83-86.
37. Mortensen, P. B., Kolvraa, S., and Christensen, E. 1980. Inhibition of the glycine cleavage system: Hyperglycinemia and hyperglycinuria caused by valproic acid. Epilepsia 21:563-569.
38. Goodman, H. O., Shihabi, Z., and Oles, K. S. 1989. Antiepileptic drugs and plasma and platelet taurine in epilepsy. Epilepsia 30:201-207.
39. Erdal, J., Gram, L., Alving, J., and Löscher, W. 1999. Changes in plasma GABA concentration during vigabatrin treatment of epilepsy: A prospective study. Epilepsy Res. 34:145-150.
40. Hagenfeldt, L., Bjerkenstedt, L., Edman, G., Sedvall, G., and Wiesel, F.-A. 1984. Amino acids in plasma and CSF and monoamine metabolites in CSF: Interrelationship in healthy subjects. J. Neurochem. 42:833-837.