Impairment of pancreatic islet β cell function induced by intermittent high glucose through oxidative and endoplasmic reticulum stress: Experiment with rat pancreatic islet β cells

National Medical Journal of China

Volumn 88, Issue 28, 2008, Pages 2002-2004

  Hou, Zhi Qiang ^a   Li, Hong Liang ^a   Zhao, Jia Jun ^a   Li, Guang Wei ^a  

^a CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

Author keywords

Endoplasmic reticulum; Hyperglycemia; Oxidative stress; Pancreatic islet cell function

Indexed keywords

3 NITROTYROSINE; 8 HYDROXYDEOXYGUANOSINE; ACTIVATING TRANSCRIPTION FACTOR 4; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; GLUCOSE; INSULIN; MESSENGER RNA; PEROXIREDOXIN 1; 3-NITROTYROSINE; 8-HYDROXY-2'-DEOXYGUANOSINE; DEOXYGUANOSINE; DRUG DERIVATIVE; PEROXIREDOXIN; TYROSINE;

ANIMAL CELL; ARTICLE; CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION REGULATION; HYPERGLYCEMIA; INSULIN RELEASE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; RAT; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; DOSE RESPONSE; DRUG EFFECT; ENDOPLASMIC RETICULUM; GENETICS; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; DEOXYGUANOSINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; OXIDATIVE STRESS; PEROXIREDOXINS; RADIOIMMUNOASSAY; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TYROSINE;

EID: 77954786048     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Hirsch IB, Brownlee M. Should minimal blood glucose variability become the gold standard of glycemic control? J Diabetes Complications, 2005, 19:178-181.
2. Meyer J, Sturis J, Kalschinski M, et al. Acute hyperglycemia alters the ability of the normal β-cell to sense and respond to glucose. Am J Physiol Endecinol Metab, 2002, 282;E917-E922.
3. Del Cuerra S, Crupillo M, Masini M, et al. Cliclazide protects human islet beta-cells from apoptosis induced by intermittent high glucose. Diabetes Metab Res Rev, 2007, 23:234-238.
4. Brock B, Mogensen JH, Cregersen S, et al. Glucose desensitization in INS-1 cells: evidence of impaired function caused by glucose metabolite (s) rather than by the glucose molecule per se. Metabolism, 2002, 51:671-677. (Pubitemid 34624831)
5. Robertson R, Zhou H, Zhang T, et al. Chronic oxidative stress as a mechanism for glucose toxicity of the beta cell in type 2 diabetes. Cell Biochem Biophys, 2007, 48:139-146. (Pubitemid 47340880)
6. Lipson KL, Fonseca SC, Ishigaki S, et al. Regulalion of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1. Cell Metab, 2006, 3:245-254. (Pubitemid 44283955)
7. Yoshida H. ER stress and diseases. FEBS J, 2007, 274:630-658.
8. Elouil H, Bensellam M, Guiot Y, et al. Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets. Diabetologia, 2007, 50:1442-1452. (Pubitemid 46879004)
9. Cnop M, Ladriere L, Hekerman P, et al. Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis. J Biol Chem, 2007, 282:3989-3997. (Pubitemid 47084497)