Effects of recombinant adenovirus-mediated double suicide genes on implanted human keloid: Experiment with athymic mice

National Medical Journal of China

Volumn 88, Issue 48, 2008, Pages 3428-3431

  Xu, Bin ^a   Liu, Zhen Zhong ^a   Zhang, Jing ^a   Zong, Xian Lei ^a   Cai, Jing Long ^a  

^a THE SECOND HOSPITAL OF SHANDONG UNIVERSITY   (China)

Author keywords

Genes, bcl 2; Genes, transgenic, suicide; Keloid; Mice, nude

Indexed keywords

CYTOSINE DEAMINASE; FLUCYTOSINE; GANCICLOVIR; PROTEIN BAX; PROTEIN BCL 2; THYMIDINE KINASE;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; ESCHERICHIA COLI; FIBROBLAST; HERPES SIMPLEX VIRUS; HISTIOCYTE; IMMUNOHISTOCHEMISTRY; KELOID; MICROSCOPY; MORPHOLOGY; MOUSE; NICK END LABELING; NONHUMAN; NUDE MOUSE; SUICIDE GENE; VIRUS RECOMBINANT; ANIMAL; BAGG ALBINO MOUSE; FEMALE; GENE THERAPY; GENETICS; HUMAN; METHODOLOGY; PATHOLOGY; SUICIDE TRANSGENE;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; FEMALE; GENE THERAPY; GENES, TRANSGENIC, SUICIDE; HUMANS; KELOID; MICE; MICE, INBRED BALB C; MICE, NUDE;

EID: 77954784961     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Al-Altar A, Mess S, Thomassen JM, et al. Keloid pathogenesis and treatment. Plast Reconstr Surg, 2006, 117:286-300.
2. Corban-Wilhelm H, Ehemann V, Becker G, et al. Comparison of different methods to assess the cytotoxic effects of cytosinc deaminase and thymidine kinase gene therapy. Cancer Gene Ther, 2004, 11:208-214.
3. Fischer U, Steffens S, Frank S, et al. Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-(fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene, 2005, 24:1231-1243.
4. Boucher PD, Im MM, Freytag SO, et al. A novel mechanism of synergistic cytotoxicity with 5-fluorocytosine and ganciclovir in double suicide gene therapy. Cancer Res, 2006, 66:3230-3237.
5. Xu B, Liu ZZ, Zhu GY, et al. Efficacy of recombinant adenovirus-mediated double suicide gene therapy in human keloid fibroblasts. Clin Exp Dermatol, 2008, 33:322-328.
6. Zeng M, Smith SK, Siegel F, et al. AdEasy system made easier by selecting the viral backbone plasmid preceding homologous recombination, 2001, 31:260-262.
7. Kuriyama S, Mitoro A, Yamazaki M, et al. Comparison of gene therapy with the herpes simplex virus thymidine kinase gene and the bacterial cytosine deaminase gene for the treatment of hepatocellular carcinoma. Scand J Gastroenterol, 1999, 34:1033-1041. (Pubitemid 29512874)
8. Fogar P, Greco E, Basso D, et al. Killer genes in pancreatic cancer therapy. Cell Mol Biol (Noisy-le-grand), 2005, 51:61-76.
9. [10) Wang X, Ji C, Ma D, et al. Antitumor effects of cytosine deaminase and thymidine kinase fusion suicide gene under the control of mdrl promoter in mdrl positive leukemia cells. Leuk Lymphoma, 2007, 48:1600-1609.
10. Shetlar MR, Shetlar DJ, Bloom RF, et al. Involution of keloid implants in athymic mice treated with pirfemidone or with triamcinolone. J Lab Clin Med, 1908, 132:491-496.