메뉴 건너뛰기




Volumn 25, Issue 8, 2010, Pages 2447-2457

Parathyroid hormone-related protein induces hypertrophy in podocytes via TGF-β1 and p27Kip1: Implications for diabetic nephropathy

Author keywords

diabetic nephropathy; hypertrophy; parathyroid hormone related protein; podocyte; PTH1R receptor

Indexed keywords

ANGIOTENSIN II; ANGIOTENSIN II ANTAGONIST; CYCLIN DEPENDENT KINASE INHIBITOR 1B; HORMONE ANTIBODY; HORMONE RECEPTOR BLOCKING AGENT; JB 4250; LEUCINE; NEUTRALIZING ANTIBODY; PARATHYROID HORMONE RECEPTOR 1; PARATHYROID HORMONE RELATED PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; GLUCOSE; PARATHYROID HORMONE-RELATED PEPTIDE (1-36); PEPTIDE FRAGMENT;

EID: 77954765040     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfq104     Document Type: Article
Times cited : (30)

References (32)
  • 1
    • 0032737294 scopus 로고    scopus 로고
    • End-stage renal failure in type 2 diabetes: A medical catastrophe of worldwide dimensions
    • Ritz E, Rychlick I, Locatelli F et al. End-stage renal failure in type 2 diabetes: a medical catastrophe of worldwide dimensions. Am J Kidney Dis 1999; 34: 795-808
    • (1999) Am J Kidney Dis , vol.34 , pp. 795-808
    • Ritz, E.1    Rychlick, I.2    Locatelli, F.3
  • 2
    • 0032815449 scopus 로고    scopus 로고
    • Molecular mechanisms of diabetic renal hypertrophy
    • DOI 10.1046/j.1523-1755.1999.00590.x
    • Wolf G, Ziyadeh FN. Molecular mechanisms of diabetic renal hypertrophy. Kidney Int 1999; 56: 393-405 (Pubitemid 29353136)
    • (1999) Kidney International , vol.56 , Issue.2 , pp. 393-405
    • Wolf, G.1    Ziyadeh, F.N.2
  • 4
    • 0034945789 scopus 로고    scopus 로고
    • Podocyte foot process broadening in experimental diabetic nephropathy: Amelioration with renin-angiotensin blockade
    • Mifsud SA, Allen TJ, Bertram JF et al. Podocyte foot process broadening in experimental diabetic nephropathy: amelioration with renin-angiotensin blockade. Diabetologia 2001; 44: 878-882
    • (2001) Diabetologia , vol.44 , pp. 878-882
    • Mifsud, S.A.1    Allen, T.J.2    Bertram, J.F.3
  • 5
    • 0031029379 scopus 로고    scopus 로고
    • Podocyte loss and progressive glomerular injury in type II diabetes
    • Pagtalunan ME, Miller PL, Jumping-Eagle S et al. Podocyte loss and progressive glomerular injury in type II diabetes. J Clin Invest 1997; 99: 342-348
    • (1997) J Clin Invest , vol.99 , pp. 342-348
    • Pagtalunan, M.E.1    Miller, P.L.2    Jumping-Eagle, S.3
  • 6
    • 0033623783 scopus 로고    scopus 로고
    • G1 kinases and transforming growth factor-pP signalling are associated with a growth pattern switch in diabetes-induced renal growth
    • Huang HC, Preisig PA. G1 kinases and transforming growth factor-pP signalling are associated with a growth pattern switch in diabetes-induced renal growth. Kidney Int 2000; 58: 162-172
    • (2000) Kidney Int , vol.58 , pp. 162-172
    • Huang, H.C.1    Preisig, P.A.2
  • 7
    • 20844461871 scopus 로고    scopus 로고
    • Angiotensin II receptor blocker inhibits p27Kip1 expression in glucose-stimulated podocytes and in diabetic glomeruli
    • Xu ZG, Yoo TH, Ryu DR et al. Angiotensin II receptor blocker inhibits p27Kip1 expression in glucose-stimulated podocytes and in diabetic glomeruli. Kidney Int 2005; 67: 944-952
    • (2005) Kidney Int , vol.67 , pp. 944-952
    • Xu, Z.G.1    Yoo, T.H.2    Ryu, D.R.3
  • 8
    • 33744971196 scopus 로고    scopus 로고
    • Role of TGF-beta in pathogenesis of diabetic nephrop-athy
    • Pantsulaia T. Role of TGF-beta in pathogenesis of diabetic nephrop-athy. Georgian Med News 2006; 131: 13-18
    • (2006) Georgian Med News , vol.131 , pp. 13-18
    • Pantsulaia, T.1
  • 9
    • 0031596570 scopus 로고    scopus 로고
    • Glomerular expression of p27Kip1 in diabetic db/db mouse: Role of hyperglycemia
    • Wolf G, Schroeder R, Thaiss F et al. Glomerular expression of p27Kip1 in diabetic db/db mouse: role of hyperglycemia. Kidney Int 1998; 53: 869-879
    • (1998) Kidney Int , vol.53 , pp. 869-879
    • Wolf, G.1    Schroeder, R.2    Thaiss, F.3
  • 10
    • 0033711708 scopus 로고    scopus 로고
    • Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle
    • Ekholm SV, Reed SI. Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle. Curr Opin Cell Biol 2000; 12: 676-684
    • (2000) Curr Opin Cell Biol , Issue.12 , pp. 676-684
    • Ekholm, S.V.1    Reed, S.I.2
  • 11
    • 0035181461 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein and its receptors: Nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets
    • Clemens TL, Cormier S, Eichinger A et al. Parathyroid hormone-related protein and its receptors: nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets. Br J Pharmacol 2001; 134: 1113-1136
    • (2001) Br J Pharmacol , vol.134 , pp. 1113-1136
    • Clemens, T.L.1    Cormier, S.2    Eichinger, A.3
  • 12
    • 0035720171 scopus 로고    scopus 로고
    • Up-regulation of parathyroid hormone-related protein in folic acid-induced acute renal failure
    • Santos S, Bosch RJ, Ortega A et al. Up-regulation of parathyroid hormone-related protein in folic acid-induced acute renal failure. Kidney Int 2001; 60: 982-995
    • (2001) Kidney Int , vol.60 , pp. 982-995
    • Santos, S.1    Bosch, R.J.2    Ortega, A.3
  • 13
    • 0032901039 scopus 로고    scopus 로고
    • Renal expression of parathyroid hormone-related protein (PTHrP) and PTH/PTHrP receptor in a rat model of tubulointerstitial damage
    • Largo R, Gomez-Garre D, Santos S et al. Renal expression of parathyroid hormone-related protein (PTHrP) and PTH/PTHrP receptor in a rat model of tubulointerstitial damage. Kidney Int 1999; 55: 82-90
    • (1999) Kidney Int , vol.55 , pp. 82-90
    • Largo, R.1    Gomez-Garre, D.2    Santos, S.3
  • 14
    • 33646909968 scopus 로고    scopus 로고
    • The parathyroid hormone-related protein system and diabetic nephropathy outcome in mice with streptozotocin-induced diabetes
    • Izquierdo A, Lopez Luna P, Ortega A et al. The parathyroid hormone-related protein system and diabetic nephropathy outcome in mice with streptozotocin-induced diabetes. Kidney Int 2006; 69: 2171-2177
    • (2006) Kidney Int , vol.69 , pp. 2171-2177
    • Izquierdo, A.1    Lopez Luna, P.2    Ortega, A.3
  • 15
    • 0036014999 scopus 로고    scopus 로고
    • Angiotensin II increases parathyroid hormone-related protein (PTHrP) and type 1 PTH/PTHrP receptor in the kidney
    • Lorenzo O, Ruiz-Ortega M, Esbrit P et al. Angiotensin II increases parathyroid hormone-related protein (PTHrP) and type 1 PTH/PTHrP receptor in the kidney. J Am Soc Nephrol 2002; 13: 1595-1607
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1595-1607
    • Lorenzo, O.1    Ruiz-Ortega, M.2    Esbrit, P.3
  • 16
    • 24344488472 scopus 로고    scopus 로고
    • Role of the renin-angiotensin system on the parathyroid hormone-related protein overexpression induced by nephrotoxic acute renal failure in the rat
    • Ortega A, Ramila D, Izquierdo A et al. Role of the renin-angiotensin system on the parathyroid hormone-related protein overexpression induced by nephrotoxic acute renal failure in the rat. JAm Soc Nephrol 2005; 16: 939-949
    • (2005) JAm Soc Nephrol , vol.16 , pp. 939-949
    • Ortega, A.1    Ramila, D.2    Izquierdo, A.3
  • 17
    • 0031563832 scopus 로고    scopus 로고
    • Rearrangements of the cytoskel-eton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines
    • Mundel P, Reiser J, Borja AZ et al. Rearrangements of the cytoskel-eton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res 1997; 236: 248-258
    • (1997) Exp Cell Res , vol.236 , pp. 248-258
    • Mundel, P.1    Reiser, J.2    Borja, A.Z.3
  • 18
    • 0036140009 scopus 로고    scopus 로고
    • Reactive oxygen species alter gene expression in podocytes: Induction of granulocyte macrophage-colony-stimulating factor
    • Greiber S, Muller B, Daemisch P et al. Reactive oxygen species alter gene expression in podocytes: induction of granulocyte macrophage-colony-stimulating factor. J Am Soc Nephrol 2002; 13: 86-95
    • (2002) J Am Soc Nephrol , vol.13 , pp. 86-95
    • Greiber, S.1    Muller, B.2    Daemisch, P.3
  • 19
    • 40849087913 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein promotes inflammation in the kidney with an obstructed ureter
    • Ramila D, Ardura JA, Esteban V et al. Parathyroid hormone-related protein promotes inflammation in the kidney with an obstructed ureter. Kidney Int 2008; 73: 835-847
    • (2008) Kidney Int , vol.73 , pp. 835-847
    • Ramila, D.1    Ardura, J.A.2    Esteban, V.3
  • 20
    • 35348874912 scopus 로고    scopus 로고
    • Effect of parathyroid-hormone-related protein on human platelet activation
    • Ortega A, Perez de Prada MT, Mateos-Caceres PJ et al. Effect of parathyroid-hormone-related protein on human platelet activation. Clin Sci 2007; 113: 319-327
    • (2007) Clin Sci , vol.113 , pp. 319-327
    • Ortega, A.1    Perez De Prada, M.T.2    Mateos-Caceres, P.J.3
  • 21
    • 33645569518 scopus 로고    scopus 로고
    • Redox dependence of glomerular epithelial cell hypertrophy in response to glucose
    • Kim NH, Rincon-Choles H, Bhandari B et al. Redox dependence of glomerular epithelial cell hypertrophy in response to glucose. Am J Physiol Renal Physiol 2006; 290: F741-F751
    • (2006) Am J Physiol Renal Physiol , vol.290
    • Kim, N.H.1    Rincon-Choles, H.2    Bhandari, B.3
  • 22
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 23
    • 33646911359 scopus 로고    scopus 로고
    • Role of parathyroid hormone-related protein in tubulointerstitial apoptosis and fibrosis after folic acid-induced nephrotoxicity
    • Ortega A, Ramila D, Ardura JA et al. Role of parathyroid hormone-related protein in tubulointerstitial apoptosis and fibrosis after folic acid-induced nephrotoxicity. JAm Soc Nephrol 2006; 17: 1594-1603
    • (2006) JAm Soc Nephrol , vol.17 , pp. 1594-1603
    • Ortega, A.1    Ramila, D.2    Ardura, J.A.3
  • 24
    • 0346734167 scopus 로고    scopus 로고
    • Prevention of acute is-chemic renal failure by targeted delivery of growth factors to the proximal tubule in transgenic mice: The efficacy of parathyroid hormone-related protein and hepatocyte growth factor
    • Fiaschi-Taesch NM, Santos S, Reddy Vet al. Prevention of acute is-chemic renal failure by targeted delivery of growth factors to the proximal tubule in transgenic mice: the efficacy of parathyroid hormone-related protein and hepatocyte growth factor. JAm Soc Nephrol 2004; 15: 112-125
    • (2004) J Am Soc Nephrol , vol.15 , pp. 112-125
    • Fiaschi-Taesch, N.M.1    Santos, S.2    Reddy, V.3
  • 25
    • 0036237648 scopus 로고    scopus 로고
    • The hypertrophic effect of transforming growth factor-beta is reduced in the absence of cyclin-dependent kinase-inhibitors p21 and p27
    • Monkawa T, Hiromura K, Wolf G et al. The hypertrophic effect of transforming growth factor-beta is reduced in the absence of cyclin-dependent kinase-inhibitors p21 and p27. J Am Soc Nephrol 2002; 13: 1172-1178
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1172-1178
    • Monkawa, T.1    Hiromura, K.2    Wolf, G.3
  • 26
    • 10944270563 scopus 로고    scopus 로고
    • Mechanical stretch induces podocyte hypertrophy in vitro
    • Petermann AT, Pippin J, Durvasula R et al. Mechanical stretch induces podocyte hypertrophy in vitro. Kidney Int 2005; 67: 157-166
    • (2005) Kidney Int , vol.67 , pp. 157-166
    • Petermann, A.T.1    Pippin, J.2    Durvasula, R.3
  • 27
    • 0027133219 scopus 로고
    • Expression of parathyroid hormone-related protein in the rat glomerulus and tubule during recovery from renal ischemia
    • Soifer NE, Van Why SK, Ganz MB et al. Expression of parathyroid hormone-related protein in the rat glomerulus and tubule during recovery from renal ischemia. J Clin Invest 1993; 92: 2850-2857
    • (1993) J Clin Invest , vol.92 , pp. 2850-2857
    • Soifer, N.E.1    Van Why, S.K.2    Ganz, M.B.3
  • 28
    • 0029808386 scopus 로고    scopus 로고
    • Differential expression of transforming growth factor-pP isoforms and receptors in experimental membranous nephropathy
    • Shankland SJ, Pippin J, Pichler RH et al. Differential expression of transforming growth factor-pP isoforms and receptors in experimental membranous nephropathy. Kidney Int 1996; 50: 116-124
    • (1996) Kidney Int , vol.50 , pp. 116-124
    • Shankland, S.J.1    Pippin, J.2    Pichler, R.H.3
  • 29
    • 0034087307 scopus 로고    scopus 로고
    • Stimulation of TGF-pP type II receptor by high glucose in mouse mesangial cells and diabetic kidney
    • Isono M, Mogyorosi A, Han DC et al. Stimulation of TGF-pP type II receptor by high glucose in mouse mesangial cells and diabetic kidney. Am J Physiol Renal Physiol 2000; 278: F830-F838
    • (2000) Am J Physiol Renal Physiol , vol.278
    • Isono, M.1    Mogyorosi, A.2    Han, D.C.3
  • 30
    • 0026787630 scopus 로고
    • High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-beta
    • Wolf G, Sharma K, Chen Y et al. High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-beta. Kidney Int 1992; 42: 647-656
    • (1992) Kidney Int , vol.42 , pp. 647-656
    • Wolf, G.1    Sharma, K.2    Chen, Y.3
  • 31
    • 0029035830 scopus 로고
    • Effects of high glucose concentrations on human mesan-gial cell proliferation
    • Cosio FG. Effects of high glucose concentrations on human mesan-gial cell proliferation. J Am Soc Nephrol 1995; 5: 1600-1609
    • (1995) J Am Soc Nephrol , vol.5 , pp. 1600-1609
    • Cosio, F.G.1
  • 32
    • 52449123137 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein interacts with vascular endothelial growth factor to promote fibrogenesis in the obstructed mouse kidney
    • Ardura JA, Berruguete R, Ramila D et al. Parathyroid hormone-related protein interacts with vascular endothelial growth factor to promote fibrogenesis in the obstructed mouse kidney. Am J Physiol Renal Physiol 2008; 295: F415-F425
    • (2008) Am J Physiol Renal Physiol , vol.295
    • Ardura, J.A.1    Berruguete, R.2    Ramila, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.