Studies on the acute toxicity, pharmacokinetics and pharmacodynamics of paliperidone derivatives - Comparison to paliperidone and risperidone in mice and rats

Basic and Clinical Pharmacology and Toxicology

Volumn 107, Issue 2, 2010, Pages 656-662

  Sun, Fengying ^a   Su, Zhengxing ^a   Sui, Cheng ^a   Zhang, Chao ^a   Yuan, Lijia ^a   Meng, Qingfan ^a   Teng, Lirong ^a   Li, Youxin ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ATYPICAL ANTIPSYCHOTIC AGENT; PALIPERIDONE; PALIPERIDONE DERIVATIVE; RISPERIDONE; SODIUM CHLORIDE; UNCLASSIFIED DRUG; AMINO ACID RECEPTOR BLOCKING AGENT; DIZOCILPINE MALEATE; ISOXAZOLE DERIVATIVE; NEUROLEPTIC AGENT; PYRIMIDINE DERIVATIVE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG DOSE COMPARISON; DRUG MEGADOSE; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; LD 50; LOCOMOTION; LOW DRUG DOSE; MALE; MAXIMUM TOLERATED DOSE; MOUSE; NONHUMAN; PHARMACODYNAMICS; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; QT INTERVAL; RAT; SCHIZOPHRENIA; ANIMAL; CHEMICALLY INDUCED; CHEMISTRY; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECTS; HEART; HYPERKINESIA; INBRED MOUSE STRAIN; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT; TOXICITY; TOXICITY TESTING;

MUS; RATTUS;

ANIMALS; ANTIPSYCHOTIC AGENTS; DISEASE MODELS, ANIMAL; DIZOCILPINE MALEATE; ELECTROCARDIOGRAPHY; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; HEART; HEART RATE; HYPERKINESIS; ISOXAZOLES; LETHAL DOSE 50; MALE; MAXIMUM TOLERATED DOSE; MICE; MICE, INBRED STRAINS; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RISPERIDONE; SCHIZOPHRENIA; TOXICITY TESTS, ACUTE;

EID: 77954747589     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2010.00552.x     Document Type: Article

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