Purification and characterization of a novel antinociceptive toxin from Cobra venom (Naja naja atra)

Toxicon

Volumn 52, Issue 5, 2008, Pages 638-646

  Jiang, Wei jian ^a   Liang, Ying xia ^b   Han, Li ping ^a   Qiu, Peng xin ^b   Yuan, Jin ^a   Zhao, Shu jin ^a  

^a GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Analgesia; Cholinergic system; Naja naja atra venom; Najanalgesin; Opioidergic system

Indexed keywords

ACETYLSALICYLIC ACID; ANTINOCICEPTIVE AGENT; ATROPINE; CARDIOTOXIN; NAJANALGESIN; NALOXONE; SNAKE VENOM; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG PURIFICATION; DRUG RESPONSE; FEMALE; HOT PLATE TEST; LATENT PERIOD; LD 50; MALE; MOUSE; NONHUMAN; PAIN ASSESSMENT; PAIN THRESHOLD; PRIORITY JOURNAL; WRITHING TEST;

ANALGESICS; ANIMALS; ATROPINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COBRA NEUROTOXIN PROTEINS; COBRA VENOMS; LETHAL DOSE 50; MICE; MICE, INBRED STRAINS; NALOXONE; NARCOTIC ANTAGONISTS; NEUROTOXINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

ANIMALIA; NAJA ATRA;

EID: 52049086449     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2008.06.030     Document Type: Article

References (39)

1. Afifiyan F., Armugam A., et al. Postsynaptic alpha-neurotoxin gene of the spitting cobra, Naja naja sputatrix: structure, organization, and phylogenetic analysis. Genome Res. 9 (1999) 259-266
2. Bliss C. The determination of dosage mortality curve from small numbers. Quart. J. Pharm. Pharmacol. 11 (1938) 192-216
3. Chang L.S., Chou Y.C., et al. A novel neurotoxin, cobrotoxin b, from Naja naja atra (Taiwan cobra) venom: purification, characterization, and gene organization. J. Biochem. 122 (1997) 1252-1259
4. Chang L.S., Lin J., et al. Genomic structures of cardiotoxin 4 and cobrotoxin from Naja naja atra (Taiwan cobra). Biochem. Biophys. Res. Commun. 239 (1997) 756-762
5. Chang L., Lin S., et al. Genetic organization of alpha-bungarotoxins from Bungarus multicinctus (Taiwan banded krait): evidence showing that the production of alpha-bungarotoxin isotoxins is not derived from edited mRNAs. Nucleic Acids Res. 27 (1999) 3970-3975
6. Chen R.Z., and Robinson S.E. The effect of cholinergic manipulations on the analgesic response to cobrotoxin in mice. Life Sci. 47 (1990) 1949-1954
7. Chen Z.X., Zhang H.L., et al. A long-form alpha-neurotoxin from cobra venom produces potent opioid-independent analgesia. Acta Pharmacol. Sin. 27 (2006) 402-408
8. Chiou S.H., Hung C.C., et al. Sequence comparison and computer modelling of cardiotoxins and cobrotoxin isolated from Taiwan cobra. Biochem. Biophys. Res. Commun. 206 (1995) 22-32
9. Cura J.E., Blanzaco D.P., et al. Phase I and pharmacokinetics study of crotoxin (cytotoxic PLA(2), NSC-624244) in patients with advanced cancer. Clin. Cancer Res. 8 (2002) 1033-1041
10. Dufton M.J., and Hider R.C. The structure and pharmacology of elapid cytotoxins. Snake Toxins (1991), Pergamon Press, A.L. Harvey. New York pp. 259-302
11. Dutta A.S., and Chaudhuri A.K. Neuropharmacological studies on the venom of Vipera russelli. Indian J. Exp. Biol. 29 (1991) 937-942
12. Eddy N.B., and Leimbach D. Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines. J. Pharmacol. Exp. Ther. 107 (1953) 385-393
13. Frolich J.C. A classification of NSAIDs according to the relative inhibition of cyclooxygenase isoenzymes. Trends Pharmacol. Sci. 18 (1997) 30-34
14. Gatineau E., Toma F., et al. Role of tyrosine and tryptophan residues in the structure-activity relationships of a cardiotoxin from Naja nigricollis venom. Biochemistry 26 (1987) 8046-8055
15. Giorgi R., Bernardi M.M., et al. Analgesic effect evoked by low molecular weight substances extracted from Crotalus durissus terrificus venom. Toxicon 31 (1993) 1257-1265
16. Grasset E. The cobra neurotoxin; pharmacology and clinical applications in the treatment of pain. Med. Hyg. (Geneve) 10 (1952) 55-58
17. Harris L., and Dewey W. Role of Cholinergic Systems in the Central Action of Narcotic Agonists and Antagonists (1972), Macmillan, London
18. Jensen T.S., and Yaksh T.L. Comparison of antinociceptive action of morphine in the periaqueductal gray, medial and paramedial medulla in rat. Brain Res. 363 (1986) 99-113
19. Karlsson E. Chemistry of Protein Toxins in Snake Venoms (1979), Springer-Verlag, New York
20. Kingery W.S. A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes. Pain 73 (1997) 123-139
21. Lachumanan R., Armugam A., et al. Structure and organization of the cardiotoxin genes in Naja naja sputatrix. FEBS Lett. 433 (1998) 119-124
22. Macht D.I. Experimental and clinical study of Cobra venom as an analgesic. Proc. Natl. Acad. Sci. U.S.A. 22 (1936) 61-71
23. Mancin A.C., Soares A.M., et al. The analgesic activity of crotamine, a neurotoxin from Crotalus durissus terrificus (South American rattlesnake) venom: a biochemical and pharmacological study. Toxicon 36 (1998) 1927-1937
24. McQuay H. Opioids in pain management. Lancet 353 (1999) 2229-2232
25. Mitra S. Snake bite in India and its management. J. Indian Med. Assoc. 85 (1987) 129-131
26. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates (1986), Academic Press, New York
27. Pedigo N.W., Dewey W.L., et al. Determination and characterization of the antinociceptive activity of intraventricularly administered acetylcholine in mice. J. Pharmacol. Exp. Ther. 193 (1975) 845-852
28. Pu X.C., Wong P.T., et al. A novel analgesic toxin (hannalgesin) from the venom of king cobra (Ophiophagus hannah). Toxicon 33 (1995) 1425-1431
29. Sivaraman T., Kumar T.K., et al. Characterization of a partially structured state in an all-beta-sheet protein. Biochem. J. 321 Pt 2 (1997) 457-464
30. Sun Y.J., Wu W.G., et al. Crystal structure of cardiotoxin V from Taiwan cobra venom: pH-dependent conformational change and a novel membrane-binding motif identified in the three-finger loops of P-type cardiotoxin. Biochemistry 36 (1997) 2403-2413
31. Takechi M., Tanaka Y., et al. Amino acid sequence of a cardiotoxin-like basic polypeptide (CLBP) with low cytotoxic activity isolated from the venom of the Formosan cobra (Naja naja atra). Biochem. Int. 11 (1985) 795-802
32. Thompson J.D., Higgins D.G., et al. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22 (1994) 4673-4680
33. Wang Y., Su D.M., et al. Antinociceptive effects of choline against acute and inflammatory pain. Neuroscience 132 (2005) 49-56
34. Warrell D. Animal toxins. Manson's Tropical Disease (1996), W.B. Saunders, C.G. London pp. 468-515
35. Xiong Y., Wang W., Song J., Pu X., Liu N., and Mao J. The Study on the Mechanism to use the Neurotoxin from Cobra Venom to Substitute Morphine (1992), National University of Singapore, Singapore
36. Yaksh T.L., Yeung J.C., et al. Systematic examination in the rat of brain sites sensitive to the direct application of morphine: observation of differential effects within the periaqueductal gray. Brain Res. 114 (1976) 83-103
37. Yang C.C. Cobrotoxin: structure and function. J. Nat. Toxins 8 (1999) 221-233
38. Zhang H.L., Han R., et al. Opiate and acetylcholine-independent analgesic actions of crotoxin isolated from crotalus durissus terrificus venom. Toxicon 48 (2006) 175-182
39. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16 (1983) 109-110