pH measurement and a rational and practical pH control strategy for high throughput cell culture system

Biotechnology Progress

Volumn 26, Issue 3, 2010, Pages 872-880

  Zhou, Haiying ^a   Purdie, Jennifer ^b   Wang, Tongtong ^b   Ouyang, Anli ^b  

^a Case Western Reserve University   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Cell culture; High throughput system; pH measurement and control

Indexed keywords

96-WELL PLATE; ACCURATELY REGULATED; BUFFER SYSTEM; CELL CULTURE PROCESS; CELL LINES; CHEMICAL EQUILIBRIUMS; ELI LILLY; EXPERIMENTAL DATA; HIGH PRODUCTIVITY; HIGH THROUGHPUT; MANUFACTURING PROCESS; PH CONTROL; PH MEASUREMENT AND CONTROL; PH MEASUREMENTS; PH VALUE; PHARMACEUTICAL INDUSTRY; PROCESS DEVELOPMENT; PROCESS PARAMETERS; PRODUCT QUALITY; SCALE DOWN MODEL; SHAKE FLASKS; SODIUM BICARBONATES; THERAPEUTIC PROTEIN;

BOTTLES; CARBOXYLIC ACIDS; CELL CULTURE; CLONE CELLS; COST REDUCTION; DRUG PRODUCTS PLANTS; MATHEMATICAL MODELS; ORGANIC ACIDS; PHASE EQUILIBRIA; PRODUCTIVITY; SODIUM; THROUGHPUT;

PH EFFECTS;

BICARBONATE; CARBON DIOXIDE; FLUORESCENT DYE;

ALGORITHM; ANIMAL; ARTICLE; BIOLOGICAL MODEL; BIOREACTOR; CHO CELL; CRICETULUS; CULTURE TECHNIQUE; HAMSTER; HIGH THROUGHPUT SCREENING; METABOLISM; METHODOLOGY; PH; PHARMACEUTICS; CHO CELL LINE; PROCEDURES;

ALGORITHMS; ANIMALS; BICARBONATES; BIOPHARMACEUTICS; BIOREACTORS; CARBON DIOXIDE; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; CRICETULUS; FLUORESCENT DYES; HIGH-THROUGHPUT SCREENING ASSAYS; HYDROGEN-ION CONCENTRATION; MODELS, BIOLOGICAL;

EID: 77954723296     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.369     Document Type: Article

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