Validated LC-MS/MS assay for the quantitative determination of vardenafil in human plasma and its application to a pharmacokinetic study

Biomedical Chromatography

Volumn 24, Issue 8, 2010, Pages 846-851

  Lake, Simon T ^a   Altman, Phillip M ^b   Vaisman, Jack ^c   Addison, Russell S ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b Altman Biomedical Consulting Pty Ltd Australia   (Australia)

^c Advanced Medical Institute Pty Ltd   (Australia)

Author keywords

Assay validation; LC MS MS; Mass spectrometry; Plasma; Vardenafil

Indexed keywords

DICHLOROMETHANE; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION SOURCES; MASS SPECTROMETERS; ORGANIC SOLVENTS; PHARMACOKINETICS; PLASMA (HUMAN); SOLVENT EXTRACTION;

ALPRAZOLAM; ASSAY VALIDATION; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN PLASMAS; ITS APPLICATIONS; LC-MS-MS; LC.MS/MS; PHARMACOKINETIC STUDIES; QUANTITATIVE DETERMINATIONS; VARDENAFIL;

MASS SPECTROMETRY;

ALPRAZOLAM; VARDENAFIL; IMIDAZOLE DERIVATIVE; PIPERAZINE DERIVATIVE; SULFONE; TRIAZINE DERIVATIVE;

ACCURACY; ADULT; ARTICLE; BLOOD SAMPLING; CORRELATION COEFFICIENT; DRUG BLOOD LEVEL; DRUG STABILITY; DRUG STRUCTURE; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETER; MASS SPECTROMETRY; NORMAL HUMAN; PLASMA; QUANTITATIVE ANALYSIS; SINGLE DRUG DOSE; SOLVENT EXTRACTION; STANDARD; VALIDATION PROCESS; BLOOD; PROCEDURES; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; IMIDAZOLES; PIPERAZINES; SULFONES; TANDEM MASS SPECTROMETRY; TRIAZINES;

EID: 77954719306     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1375     Document Type: Article

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