HDL/apolipoprotein A-I binds to macrophage-derived progranulin and suppresses its conversion into proinflammatory granulins

Journal of Atherosclerosis and Thrombosis

Volumn 17, Issue 6, 2010, Pages 568-577

  Okura, Hanayuki ^a,b,c   Yamashita, Shizuya ^b   Ohama, Tohru ^b   Saga, Ayami ^a   Yamamoto Kakuta, Aya ^a   Hamada, Yoko ^a   Sougawa, Nagako ^a   Ohyama, Reiko ^a   Sawa, Yoshiki ^b   Matsuyama, Akifumi ^a  

^a INSTITUTE OF BIOMEDICAL RESEARCH AND INNOVATION   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

Author keywords

Acrogranin; Apolipoprotein A I; HDL; Macrophage; PCDGF; Proepithelin; Progranulin

Indexed keywords

APOLIPOPROTEIN A1; GRANULIN; HIGH DENSITY LIPOPROTEIN; INTERLEUKIN 1BETA; PROGRANULIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; AUTACOID; CULTURE MEDIUM; GRANULIN PRECURSOR PROTEIN; PROTEIN BINDING; SIGNAL PEPTIDE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; EXPRESSION VECTOR; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INFLAMMATION; MACROPHAGE; PROTEIN PURIFICATION; REAL TIME POLYMERASE CHAIN REACTION; BIOSYNTHESIS; CELL CULTURE; CELL LINE; CHEMISTRY; CULTURE MEDIUM; METABOLISM; PARACRINE SIGNALING; PHYSIOLOGY; SECRETION (PROCESS);

ANTI-INFLAMMATORY AGENTS; APOLIPOPROTEIN A-I; CELL LINE; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; HUMANS; INFLAMMATION MEDIATORS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOPROTEINS, HDL; MACROPHAGES; PARACRINE COMMUNICATION; PROTEIN BINDING;

EID: 77954717645     PISSN: 13403478     EISSN: 18803873     Source Type: Journal    
DOI: 10.5551/jat.3921     Document Type: Article

References (19)

1. Brewer HB Jr: HDL metabolism and the role of HDL in the treatment of high-risk patients with cardiovascular disease. Curr Cardiol Rep, 2007; 9: 486-492
2. Yamashita S, Hirano K, Sakai N, Matsuzawa Y: Molecular biology and pathophysiological aspects of plasma cholesteryl ester transfer protein. Biochim Biophys Acta, 2000; 1529: 257-275
3. Yokoyama S: ABCA1 and biogenesis of HDL. J Atheroscler Thromb, 2006; 13: 1-15
4. Ansell BJ, Watson KE, Fogelman AM, Navab M, FonarowGC: High-density lipoprotein function. Recent advances. J Am Coll Cardiol, 2005; 46: 1792-1798
5. Fresco C, Maggioni AP, and LATIN Investigators, Variations in lipoprotein levels after myocardial infarction and unstable angina: the LATIN trial. Ital Heart J, 2002; 3: 587-592
6. Olsson AG, Schwartz GG, Szarek M, Sasiela WJ, Ezekowitz MD, Ganz P, Oliver MF, Waters D, Zeiher A: Highdensity lipoprotein, but not low-density lipoprotein cholesterol levels influence short-term prognosis after acute coronary syndrome: results from the MIRACL trial. Eur Heart J, 2005; 26: 890-896
7. Chapman MJ: From pathophysiology to targeted therapy for atherothrombosis: a role for the combination of statin and aspirin in secondary prevention. Pharmacol Ther, 2007; 113: 184-196
8. He Z, Bateman A: Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis. J Mol Med, 2003; 81: 600-612
9. Matsuyama A, Yamashita S, Sakai N, Maruyama T, Okuda E, Hirano K, Kihara S, Hiraoka H, Matsuzawa Y: Identification of a GPI-anchored type HDL-binding protein on human macrophages. Biochem Biophys Res Commun, 2000; 272: 864-871
10. Zhu J, Nathan C, Jin W, Sim D, Ashcroft GS, Wahl SM, Lacomis L, Erdjument-Bromage H, Tempst P, Wright CD, Ding A: Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Cell, 2002; 111: 867-878
11. Ong CH, Bateman A: Progranulin (granulin-epithelin precursor, PC-cell derived growth factor, acrogranin) in proliferation and tumorigenesis. Histol Histopathol, 2003; 18: 1275-1288
12. Díaz-Cueto L, Stein P, Jacobs A, Schultz RM, Gerton GL: Modulation of mouse preimplantation embryo development by acrogranin (epithelin/granulin precursor). Dev Biol, 2000; 217: 406-418
13. He Z, Ong CH, Halper J, Bateman A: Progranulin is a mediator of the wound response. Nat Med, 2003; 9: 225-229
14. Ong CH, He Z, Kriazhev L, Shan X, Palfree RG, Bateman A: Regulation of progranulin expression in myeloid cells. Am J Physiol Regul Integr Comp Physiol, 2006; 291: R1602-1612
15. Baker M, Mackenzie IR, Pickering-Brown SM, Gass J, Rademakern R, Lindholm C, et al: Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature, 2006; 442: 916-919
16. Cruts M, Gijselinck I, van der Zee J, Engelborghs S, Wils H, Pirici D, et al: Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21. Nature, 2006; 442: 920-924
17. Shin WS, Szuba A, Rockson SG: The role of chemokines in human cardiovascular pathology: enhanced biological insights, Atherosclerosis, 2002; 160: 91-102
18. Bhandari V, Daniel R, Lim PS, Bateman A: Structural and functional analysis of a promoter of the human granulin/epithelin gene. Biochem J, 1996; 319: 441-447
19. Baba T, Nemoto H, Watanabe K, Arai Y, Gerton GL: Exon/intron organization of the gene encoding the mouse epithelin/granulin precursor (acrogranin). FEBS Lett, 1993; 322: 89-94