Targeting the brain: Neuroprotection and neurorestoration in ischemic stroke

Pharmacotherapy

Volumn 30, Issue 7 PART 2, 2010, Pages

  Saver, Jeffrey L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Citicoline; Magnesium sulfate; Neuroprotection; Neurorestoration; Stroke

Indexed keywords

ANTICONVULSIVE AGENT; ANTIINFLAMMATORY AGENT; APOPTOSIS INHIBITOR; CALCIUM CHANNEL BLOCKING AGENT; CHOLINE; CHOLINE ALFOSCERATE; CITICOLINE; CYTOKINE RECEPTOR ANTAGONIST; MAGNESIUM SULFATE; PHOSPHATIDYLCHOLINE;

ATTENTION; BLOOD; BLOOD VESSEL; BRAIN CELL; BRAIN FUNCTION; BRAIN INJURY; BRAIN ISCHEMIA; CLINICAL TRIAL; DISEASE SEVERITY; EMERGENCY CARE; EPILEPTIC STATE; FEASIBILITY STUDY; HUMAN; HYPOXIA; INFORMED CONSENT; LOS ANGELES MOTOR SCALE; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; NERVE CELL PLASTICITY; NEUROPROTECTION; NONHUMAN; ORIENTATION; RATING SCALE; REVIEW; TELEMEDICINE;

ANIMALS; BRAIN ISCHEMIA; CLINICAL TRIALS AS TOPIC; FEMALE; HUMANS; MALE; NEUROPROTECTIVE AGENTS; RATS; STROKE; TIME FACTORS; TREATMENT OUTCOME;

EID: 77954713964     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.30.pt2.62S     Document Type: Review

References (29)

1. Ovbiagele B, Kidwell CS, Starkman S, Saver JL. Neuroprotective agents for the treatment of acute ischemic stroke. Curr Neurol Neurosci Rep 2003;3:9-20. (Pubitemid 38898978)
2. Ginsberg MD. Current status of neuroprotection for cerebral ischemia: synoptic overview. Stroke 2009;40:S111-14.
3. Kidwell CS, Liebeskind DS, Starkman S, Saver JL. Trends in acute ischemic stroke trials through the 20th century. Stroke 2001;32:1349-59.
4. Donnan GA. The 2007 Feinberg lecture: a new road map for neuroprotection. Stroke 2008;39:242.
5. Ferguson KN, Kidwell CS, Starkman S, Saver JL. Hyperacute treatment initiation in neuroprotective agent stroke trials. J Stroke Cerebrovasc Dis 2004;13:109-12. (Pubitemid 38885683)
6. Alldredge BK, Gelb AM, Isaacs SM, et al. A comparison of lorazepam, diazepam, and placebo for the treatment of out-ofhospital status epilepticus. N Engl J Med 2001;345:631-7.
7. Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002;346:557-63.
8. Muir KW. Therapeutic potential of magnesium in the treatment of acute stroke. J Stroke Cerebrovasc Dis 2000;9:257-67.
9. Longstreth WT Jr, Fahrenbruch CE, Olsufka M, et al. Randomized clinical trial of magnesium, diazepam, or both after out-of-hospital cardiac arrest. Neurology 2002;59:506-14. (Pubitemid 34919982)
10. Crowther CA, Hiller JE, Doyle LW, Haslam RR. Effect of magnesium sulfate given for neuroprotection before preterm birth: a randomized controlled trial. JAMA 2003;290:2669-76.
11. Bhudia SK, Cosgrove DM, Naugle RI, et al. Magnesium as a neuroprotectant in cardiac surgery: a randomized clinical trial. J Thorac Cardiovasc Surg 2006;131:853-61.
12. van den Bergh WM, Algra A, van Kooten F, et al. Magnesium sulfate in aneurysmal subarachnoid hemorrhage: a randomized controlled trial. Stroke 2005;36:1011-15.
13. Muir KW, Lees KR, Ford I, Davis S, for the Intravenous Magnesium Efficacy in Stroke (IMAGES) Study Investigators. Magnesium for acute stroke (intravenous magnesium efficacy in stroke trial): randomised controlled trial. Lancet 2004;363: 439-45.
14. Saver JL, Kidwell C, Eckstein M, Starkman S, for the FAST-MAG Pilot Trial Investigators. Prehospital neuroprotective therapy for acute stroke: results of the field administration of stroke therapy - magnesium (FAST-MAG) pilot trial. Stroke 2004;35:e106-8.
15. Kidwell CS, Starkman S, Eckstein M, et al. Identifying stroke in the field. Prospective validation of the Los Angeles prehospital stroke screen (LAPSS). Stroke 2000;31:71-6.
16. Llanes JN, Kidwell CS, Starkman S, et al. The Los Angeles motor scale (LAMS): a new measure to characterize stroke severity in the field. Prehosp Emerg Care 2004;8:46-50. (Pubitemid 38049892)
17. National Institute of Neurological Disorders and Stroke. Know stroke. Know the signs. Act in time. NIH stroke scale. Available from http://www.ninds.nih.gov/doctors/NIH-Stroke-Scale-Booklet.pdf. Accessed April 26, 2010.
18. Sanossian N, Starkman S, Liebeskind DS, et al, for the FASTMAG Trial Investigators. Simultaneous ring voice-overinternet phone system enables rapid physician elicitation of explicit informed consent in prehospital stroke treatment trials. Cerebrovasc Dis 2009;28:539-44.
19. Saver JL, Eckstein M, Stratton SJ, et al, for the FAST-MAG Trial Investigators. The field administration of stroke therapy - magnesium (FAST-MAG) phase 3 trial. Poster presented at the international stroke conference, San Antonio, TX, February 24-26, 2010.
20. Gutiérrez M, Merino JJ, de Leciñana MA, Díez-Tejedor E. Cerebral protection, brain repair, plasticity and cell therapy in ischemic stroke. Cerebrovasc Dis 2009;27(suppl 1):177-86.
21. Birbaumer N, Murguialday AR, Cohen L. Brain-computer interface in paralysis. Curr Opin Neurol 2008;21:634-8.
22. Secades JJ, Lorenzo JL. Citicoline: pharmacological and clinical review, 2006 update. Methods Find Exp Clin Pharmacol 2006;28(suppl B):1-56.
23. Saver JL. Citicoline: update on a promising and widely available agent for neuroprotection and neurorepair. Rev Neurol Dis 2008;5:167-77.
24. Hurtado O, Cárdenas A, Pradillo JM, et al. A chronic treatment with CDP-choline improves functional recovery and increases neuronal plasticity after experimental stroke. Neurobiol Dis 2007;26:105-11. (Pubitemid 46436490)
25. Rema V, Bali KK, Ramachandra R, et al. Cytidine-5-diphosphocholine supplement in early life induces stable increase in dendritic complexity of neurons in the somatosensory cortex of adult rats. Neuroscience 2008;155: 556-64.
26. Warach SM, Harnett K. Predictive validity of MRI as a surrogate endpoint in stroke trials: change in lesion volume predicts clinical outcome [abstract]. Stroke 2002;33:356.
27. Warach S, Pettigrew LC, Dashe JF, et al, for the Citicoline 010 Investigators. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Ann Neurol 2000;48:713-22.
28. Álvarez-Sabín J, Jacas C, Ortega G, et al. Citicoline influence in cognitive decline after first ischemic stroke. Presented at the XII Congreso de la Sociedad Iberoamericana de Enfermedad Cerebro Vascular, Asunción, Paraguay, September 2-4, 2009.
29. Dávalos A. Citicoline. Int J Stroke 2008;3(suppl 1):440.