In vitro evaluation of dissolution behavior for a colon-specific drug delivery system (CODES™) in multi-pH media using United States Pharmacopeia apparatus II and III

AAPS PharmSciTech

Volumn 3, Issue 4, 2002, Pages

  Li, Jinhe ^a   Yang, Libo ^a   Ferguson, Sheila M ^a   Hudson, Tom J ^a   Watanabe, Shunsuke ^b   Katsuma, Masataka ^b   Fix, Joseph A ^a  

^a Yamanouchi Shaklee Pharma   (United States)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

Acetaminophen (APAP); Colon specific drug delivery; Dissolution automation; USP apparatus II (paddle); USP apparatus III (reciprocating cylinder)

Indexed keywords

PARACETAMOL; EUDRAGIT; EUDRAGIT-E; GASTROINTESTINAL AGENT; LACTULOSE; METHACRYLIC ACID DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; IN VITRO STUDY; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; STOMACH PH; TABLET FORMULATION; UNITED STATES; CHEMICAL MODEL; CHEMISTRY; COLON; COMPARATIVE STUDY; DELAYED RELEASE FORMULATION; DRUG SCREENING; ENTERIC COATED TABLET; INSTRUMENTATION; MEDICAL LITERATURE; METABOLISM; METHODOLOGY; PH; PHARMACEUTICS; SOLUBILITY;

ACETAMINOPHEN; COLON; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; GASTROINTESTINAL AGENTS; HYDROGEN-ION CONCENTRATION; LACTULOSE; METHACRYLATES; MODELS, CHEMICAL; PHARMACOPOEIAS; SOLUBILITY; TABLETS, ENTERIC-COATED; TECHNOLOGY, PHARMACEUTICAL; UNITED STATES;

EID: 23144459633     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt030433     Document Type: Article

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