Immune status and apoptosis activation during brain death

Shock

Volumn 33, Issue 4, 2010, Pages 353-362

  Adrie, Christophe ^a,b   Monchi, Mehran ^c,d   Fulgencio, Jean Pierre ^e   Cottias, Pascal ^f   Haouache, Hakim ^a   Alvarez Gonzalvez, Antonio ^a   Guerrini, Patrice ^g   Cavaillon, Jean Marc ^h   Adib Conquy, Minou ^h  

^a DELAFONTAINE HOSPITAL   (France)

^b Paris Descartes University ^*  (France)

^c Institut Jacques Cartier   (France)

^d UNIVERSITY OF LIÈGE   (Belgium)

^e HÔPITAL TENON   (France)

^f CENTRE HOSPITALIER VICTOR DUPOUY   (France)

^g BICÊTRE HOSPITAL   (France)

^h INSTITUT PASTEUR   (France)

Author keywords

Apoptosis; Brain death; Endotoxin; Graft; Heart arrest; Inflammation; Transplantation

Indexed keywords

CASPASE 9; ENDOTOXIN; GAMMA INTERFERON; INTERLEUKIN 10; MESSENGER RNA; TUMOR NECROSIS FACTOR; CYTOKINE;

ADULT; AGED; APOPTOSIS; ARTICLE; BELGIUM; BRAIN DEATH; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; FRANCE; HEAD INJURY; HEART ARREST; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE STATUS; INFLAMMATION; INTENSIVE CARE UNIT; LEUKOCYTE; MALE; MUSCLE BIOPSY; SKELETAL MUSCLE; TISSUE INJURY; WESTERN BLOTTING; BLOOD; GRAFT SURVIVAL; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; STROKE; TRANSPLANTATION;

ADULT; AGED; APOPTOSIS; BRAIN DEATH; CASPASE 9; CRANIOCEREBRAL TRAUMA; CYTOKINES; ENDOTOXINS; FEMALE; GRAFT SURVIVAL; HEART ARREST; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; MUSCLE, SKELETAL; RNA, MESSENGER; STROKE; TISSUE AND ORGAN PROCUREMENT;

EID: 77954692381     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e3181b65b99     Document Type: Article

References (48)

1. Wijdicks EF: The diagnosis of brain death. N Engl J Med 344:1215-1221, 2001.
2. Gasser M, Waaga AM, Laskowski IA, Tilney NL: The influence of donor brain death on short and long-term outcome of solid organ allografts. Ann Transplant 5:61-67, 2000.
3. Gridelli B, Remuzzi G: Strategies for making more organs available for transplantation. N Engl J Med 343:404-410, 2000.
4. Wood KE, Becker BN, McCartney JG, D'Alessandro AM, Coursin DB: Care of the potential organ donor. N Engl J Med 351:2730-2739, 2004.
5. Weiss S, Kotsch K, Francuski M, Reutzel-Selke A, Mantouvalou L, Klemz R, Kuecuek O, Jonas S, Wesslau C, Ulrich F, et al.: Brain death activates donor organs and is associated with a worse I/R injury after liver transplantation. Am J Transplant 7:1584-1593, 2007.
6. Amado JA, Lopez-Espadas F, Vazquez-Barquero A, Salas E, Riancho JA, Lopez-Cordovilla JJ, Garcia-Unzueta MT: Blood levels of cytokines in brain-dead patients: relationship with circulating hormones and acute-phase reactants. Metabolism 44:812-816, 1995.
7. Fisher AJ, Donnelly SC, Hirani N, Burdick MD, Strieter RM, Dark JH, Corris PA: Enhanced pulmonary inflammation in organ donors following fatal non-traumatic brain injury. Lancet 353:1412-1413, 1999.
8. Fisher AJ, Donnelly SC, Hirani N, Haslett C, Strieter RM, Dark JH, Corris PA: Elevated levels of interleukin-8 in donor lungs is associated with early graft failure after lung transplantation. Am J Respir Crit Care Med 163:259-265, 2001.
9. Wagner FD, Jonitz B, Potapov EV, Qedra N, Wegscheider K, Abraham K, Ivanitskaia EA, Loebe M, Hetzer R: Procalcitonin, a donor-specific predictor of early graft failure-related mortality after heart transplantation. Circulation 104:I192-I196, 2001.
10. Le Gall JR, Lemeshow S, Saulnier F: A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA 270:2957-2963, 1993.
11. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H, Reinhart CK, Suter PM, Thijs LG: The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 22:707-710, 1996.
12. Adrie C, Adib-Conquy M, Laurent I, Monchi M, Vinsonneau C, Fitting C, Fraisse F, Dinh-Xuan A, Carli P, Spaulding C, et al.: Successful cardiopulmonary resuscitation after cardiac arrest as a "sepsis like" syndrome. Circulation 106:562-568, 2002.
13. Keselman HJ, Cribbie R, Holland B: Controlling the rate of type I error over a large set of statistical tests. Br J Math Stat Psychol 55:27-39, 2002.
14. Borge BA, Kalland KH, Olsen S, Bletsa A, Berggreen E, Wiig H: Cytokines are produced locally by myocytes in rat skeletal muscle during endotoxemia. Am J Physiol Heart Circ Physiol 296:H735-H744, 2009.
15. Adrie C, Haouache H, Saleh M, Memain N, Laurent I, Thuong M, Darques L, Guerrini P, Monchi M: An underrecognized source of organ donors: patients with brain death after successfully resuscitated cardiac arrest. Intensive Care Med 34:132-137, 2008.
16. Ali AA, Lim E, Thanikachalam M, Sudarshan C, White P, Parameshwar J, Dhital K, Large SR: Cardiac arrest in the organ donor does not negatively influence recipient survival after heart transplantation. Eur J Cardiothorac Surg 31:929-933, 2007.
17. Wilson DJ, Fisher A, Das K, Goerlitz F, Holland BK, De La Torre AN, Merchant A, Seguel J, Samanta AK, Koneru B: Donors with cardiac arrest: improved organ recovery but no preconditioning benefit in liver allografts. Transplantation 75:1683-1687, 2003.
18. Cavaillon JM, Adib-Conquy M, Fitting C, Adrie C, Payen D: Cytokine cascade in sepsis. Scand J Infect Dis 35:535-544, 2003.
19. Kusaka M, Fukami N, Sasaki H, Higuchi T, Ishikawa K, Shiroki R, Hoshinaga K: IP-10, apoptotic genes, and calcineurin subtype messenger RNA kinetics occurring in rat renal isografts from brain-dead donors. Transplant Proc 37: 361-363, 2005.
20. Olszyna DP, Prins JM, Dekkers PE, De Jonge E, Speelman P, Van Deventer SJ, Van Der Poll T: Sequential measurements of chemokines in urosepsis and experimental endotoxemia. J Clin Immunol 19:399-405, 1999.
21. Gasser M, Waaga AM, Laskowski IA, Tilney NL: Organ transplantation from brain dead donors: its impact on short and long term outcome revisited. Transplant Rev 15:1-10, 2001.
22. Chen YW, Shi R, Geraci N, Shrestha S, Gordish-Dressman H, Pachman LM: Duration of chronic inflammation alters gene expression in muscle from untreated girls with juvenile dermatomyositis. BMC Immunol 9:43, 2008.
23. Witasp A, Nordfors L, Schalling M, Nygren J, Ljungqvist O, Thorell A: Increased expression of inflammatory pathway genes in skeletal muscle during surgery. Clin Nutr 28:291-298, 2009.
24. Carmo-Araujo EM, Dal-Pai-Silva M, Dal-Pai V, Cecchini R, Anjos Ferreira AL: Ischaemia and reperfusion effects on skeletal muscle tissue: morphological and histochemical studies. Int J Exp Pathol 88:147-154, 2007.
25. Silverman GA, Bird PI, Carrell RW, Church FC, Coughlin PB, Gettins PG, Irving JA, Lomas DA, Luke CJ, Moyer RW, et al.: The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature. J Biol Chem 276:33293-33296, 2001.
26. Marie C, Losser MR, Fitting C, Kermarrec N, Payen D, Cavaillon JM: Cytokines and soluble cytokine receptors in pleural effusions from septic and nonseptic patients. Am J Respir Crit Care Med 156:1515-1522, 1997.
27. Zhang Y, Pilon G, Marette A, Baracos VE: Cytokines and endotoxin induce cytokine receptors in skeletal muscle. Am J Physiol Endocrinol Metab 279: E196-E205, 2000.
28. Cavaillon JM, Adrie C, Fitting C, Adib-Conquy M: Reprogramming of circulatory cells in sepsis and SIRS. J Endotoxin Res 11:311-320, 2005.
29. Cavaillon JM, Adib-Conquy M, Cloez-Tayarani I, Fitting C: Immunodepression in sepsis and SIRS assessed by ex vivo cytokine production is not a generalized phenomenon: a review. J Endotoxin Res 7:85-93, 2001.
30. Muret J, Marie C, Fitting C, Payen D, Cavaillon JM: Ex vivo T-lymphocyte derived cytokine production in SIRS patients is influenced by experimental procedures. Shock 13:169-174, 2000.
31. Stein AB, Bolli R, Guo Y, Wang OL, Tan W, Wu WJ, Zhu X, Zhu Y, Xuan YT: The late phase of ischemic preconditioning induces a prosurvival genetic program that results in marked attenuation of apoptosis. J Mol Cell Cardiol 42:1075-1085, 2007.
32. Jee SH, Shen SC, Chiu HC, Tsai WL, Kuo ML: Overexpression of interleukin-6 in human basal cell carcinoma cell lines increases anti-apoptotic activity and tumorigenic potency. Oncogene 20:198-208, 2001.
33. Kobayashi S, Werneburg NW, Bronk SF, Kaufmann SH, Gores GJ: Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells. Gastroenterology 128: 2054-2065, 2005.
34. Curcio C, Asheld JJ, Chabla JM, Ayubcha D, Hallas BH, Horowitz JM, Torres G: Expression profile of Bag 1 in the postmortem brain. J Chem Neuroanat 32:191-195, 2006.
35. Gotz R, Wiese S, Takayama S, Camarero GC, Rossoll W, Schweizer U, Troppmair J, Jablonka S, Holtmann B, Reed JC, et al.: Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells. Nat Neurosci 8:1169-1178, 2005.
36. Homma S, Iwasaki M, Shelton GD, Engvall E, Reed JC, Takayama S: BAG3 deficiency results in fulminant myopathy and early lethality. Am J Pathol 169: 761-773, 2006.
37. Mica L, Harter L, Trentz O, Keel M: Endotoxin reduces CD95-induced neutrophil apoptosis by cIAP-2-mediated caspase-3 degradation. J Am Coll Surg 199:595-602, 2004.
38. O'Neill AJ, Doyle BT, Molloy E, Watson C, Phelan D, Greenan MC, Fitzpatrick JM, Watson RW: Gene expression profile of inflammatory neutrophils: alterations in the inhibitors of apoptosis proteins during spontaneous and delayed apoptosis. Shock 21:512-518, 2004.
39. Van de Craen M, Van Loo G, Pype S, Van Criekinge W, Van den brande I, Molemans F, Fiers W, Declercq W, Vandenabeele P: Identification of a new caspase homologue: caspase-14. Cell Death Differ 5:838-846, 1998.
40. Seidelin JB, Nielsen OH: Expression profiling of apoptosis-related genes in enterocytes isolated from patients with ulcerative colitis. APMIS 114:508-517, 2006.
41. Krajewska M, Rosenthal RE, Mikolajczyk J, Stennicke HR, Wiesenthal T, Mai J, Naito M, Salvesen GS, Reed JC, Fiskum G, et al.: Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation. Exp Neurol 189:261-279, 2004.
42. Birks EJ, Yacoub MH, Burton PS, Owen V, Pomerance A, O'Halloran A, Banner NR, Khaghani A, Latif N: Activation of apoptotic and inflamma- tory pathways in dysfunctional donor hearts. Transplantation 70:1498-1506, 2000.
43. Kirsch M, Bertrand S, Lecerf L, Ginat M, Garnier JP, Loisance D: Brain death-induced myocardial dysfunction: a role for apoptosis? Transplant Proc 31: 1713-1714, 1999.
44. Van Der Hoeven JA, Moshage H, Schuurs T, Nijboer M, Van Schilfgaarde R, Ploeg RJ: Brain death induces apoptosis in donor liver of the rat. Transplantation 76:1150-1154, 2003.
45. Murugan R, Venkataraman R, Wahed AS, Elder M, Hergenroeder G, Carter M, Madden NJ, Powner D, Kellum JA: Increased plasma interleukin-6 in donors is associated with lower recipient hospital-free survival after cadaveric organ transplantation. Crit Care Med 36:1810-1816, 2008.
46. Kellum JA, Venkataraman R, Powner D, Elder M, Hergenroeder G, Carter M: Feasibility study of cytokine removal by hemoadsorption in brain-dead humans. Crit Care Med 36:268-272, 2008.
47. Singer M, De Santis V, Vitale D, Jeffcoate W: Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation. Lancet 364:545-548, 2004.
48. Sanchez-Fructuoso AI, Marques M, Prats D, Conesa J, Calvo N, Perez-Contin MJ, Blazquez J, Fernandez C, Corral E, Del Rio F, et al.: Victims of cardiac arrest occurring outside the hospital: a source of transplantable kidneys. Ann Intern Med 145:157-164, 2006.