Toxicity against gastric cancer cells by combined treatment with 5-fluorouracil and mitomycin c: Implication in oxidative stress

Cancer Chemotherapy and Pharmacology

Volumn 66, Issue 3, 2010, Pages 517-526

  Matsunaga, Toshiyuki ^a   Tsuji, Yoshitaka ^b   Kaai, Kairyu ^b   Kohno, Saki ^a   Hirayama, Renzo ^b   Alpers, David H ^c   Komoda, Tsugikazu ^b   Hara, Akira ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b SAITAMA MEDICAL UNIVERSITY   (Japan)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

5 Fluorouracil; Gastric cancer; Mitomycin c; Reactive oxygen species; Superoxide dismutase

Indexed keywords

CASPASE; CYTOCHROME C; FLUOROURACIL; MITOMYCIN C; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; ANTINEOPLASTIC AGENT; MITOMYCIN; SUPEROXIDE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER COMBINATION CHEMOTHERAPY; CELL LEVEL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG POTENTIATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; STOMACH CANCER; WESTERN BLOTTING; CELL SURVIVAL; DRUG EFFECT; METABOLISM; MITOCHONDRION; PATHOLOGY; STOMACH TUMOR; TUMOR CELL LINE;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BLOTTING, WESTERN; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROMES C; DRUG SYNERGISM; FLUOROURACIL; HUMANS; MITOCHONDRIA; MITOMYCIN; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; STOMACH NEOPLASMS; SUPEROXIDE DISMUTASE; SUPEROXIDES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77954685075     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-009-1192-5     Document Type: Article

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