Serum uric acid levels and leukocyte nitric oxide production in multiple sclerosis patients outside relapses

Journal of the Neurological Sciences

Volumn 231, Issue 1-2, 2005, Pages 41-44

  Mostert, Jop P ^a   Ramsaransing, Geeta S M ^a   Heersema, Dorothea J ^a   Heerings, Marco ^a   Wilczak, Nadine ^a   De Keyser, Jacques ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Disease activity; Multiple sclerosis; Nitric oxide; Peroxynitrite; Uric acid

Indexed keywords

NITRIC OXIDE; NITRITE; URATE OXIDASE; URIC ACID;

ADULT; ANALYTIC METHOD; ARTICLE; BLOOD; CELL LYSATE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ACTIVITY; FEMALE; HUMAN; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; RECURRENT DISEASE; SUPERNATANT; URIC ACID BLOOD LEVEL;

EID: 15944414616     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2004.12.008     Document Type: Article

References (22)

1. G. Toncev, B. Milicic, S. Toncev, and G. Samardzic Serum uric acid levels in multiple sclerosis patients correlate with activity of disease and blood-brain barrier dysfunction Eur. J. Neurol. 9 2002 221 226
2. S. Sotgiu, M. Pugliatti, A. Sanna, A. Sotgiu, M.L. Fois, and G. Arru Serum uric acid and multiple sclerosis Neurol. Sci. 23 2002 183 188
3. D.C. Hooper, S. Spitsin, R.B. Kean, J.M. Champion, G.M. Dickson, and I. Chaudhry Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis Proc. Natl. Acad. Sci. U. S. A. 95 1998 675 680
4. J. Drulovic, I. Dujmovic, N. Stojsavljevic, S. Mesaros, S. Andjelkovic, and D. Miljkovic Uric acid levels in sera from patients with multiple sclerosis J. Neurol. 248 2001 121 126
5. K.J. Smith, R. Kapoor, and P.A. Felts Demyelination: the role of reactive oxygen and nitrogen species Brain Pathol. 9 1999 69 92
6. K.J. Smith, and H. Lassmann The role of nitric oxide in multiple sclerosis Lancet Neurol. 1 2002 232 241
7. G.S. Ramsaransing, A. Teelken, A.V. Arutjunyan, and J. De Keyser Peripheral blood leukocyte NO production in MS patients with a benign vs progressive course Neurology 62 2004 239 242
8. G. Acar, F. Idiman, E. Idiman, G. Kirkali, H. Cakmakci, and S. Ozakbas Nitric oxide as an activity marker in multiple sclerosis J. Neurol. 250 2003 588 592
9. A.I. Danilov, M. Andersson, N. Bavand, N.P. Wiklund, T. Olsson, and L. Brundin Nitric oxide metabolite determinations reveal continuous inflammation in multiple sclerosis J. Neuroimmunol. 136 2003 112 118
10. A. Svenningsson, A.S. Petersson, O. Andersen, and G.K. Hansson Nitric oxide metabolites in CSF of patients with MS are related to clinical disease course Neurology 53 1999 1880 1882
11. T. Yamashita, Y. Ando, K. Obayashi, M. Uchino, and M. Ando Changes in nitrite and nitrate (NO2-/NO3-) levels in cerebrospinal fluid of patients with multiple sclerosis J. Neurol. Sci. 153 1997 32 34
12. L. Brundin, E. Morcos, T. Olsson, N.P. Wiklund, and M. Andersson Increased intrathecal nitric oxide formation in multiple sclerosis; cerebrospinal fluid nitrite as activity marker Eur. J. Neurol. 6 1999 585 590
13. N. Yuceyar, D. Taskiran, and A. Sagduyu Serum and cerebrospinal fluid nitrite and nitrate levels in relapsing-remitting and secondary progressive multiple sclerosis patients Clin. Neurol. Neurosurg. 103 2001 206 211
14. A.K. Percy, and R.O. Brady Metachromatic leukodystrophy: diagnosis with samples of venous blood Science 161 1968 594 595
15. O.H. Lowry, N.J. Rosenbrough, A. Farr, and R.J. Randall Protein measurement with the folin phenol reagent J. Biol. Chem. 193 1951 265 275
16. L.C. Green, D.A. Wagner, J. Glogowski, P.L. Skipper, J.S. Wishnok, and S.R. Tannenbaum Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids Anal. Biochem. 126 1982 131 138
17. J. Drulovic, I. Dujmovic, N. Stojsavljevic, S. Mesaros, S. Andjelkovic, and D. Miljkovic Uric acid levels in sera from patients with multiple sclerosis J. Neurol. 248 2001 121 126
18. D.C. Hooper, O. Bagasra, J.C. Marini, A. Zborek, S.T. Ohnishi, and R. Kean Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis Proc. Natl. Acad. Sci. U. S. A. 94 1997 2528 2533
19. D.C. Hooper, G.S. Scott, A. Zborek, T. Mikheeva, R.B. Kean, and H. Koprowski Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis FASEB J. 14 2000 691 698
20. R.B. Kean, S.V. Spitsin, T. Mikheeva, G.S. Scott, and D.C. Hooper The peroxynitrite scavenger uric acid prevents inflammatory cell invasion into the central nervous system in experimental allergic encephalomyelitis through maintenance of blood-central nervous system barrier integrity J. Immunol. 165 2000 6511 6518
21. G. Toncev, B. Milicic, S. Toncev, and G. Samardzic High-dose methylprednisolone therapy in multiple sclerosis increases serum uric acid levels Clin. Chem. Lab. Med. 40 2002 505 508
22. C.S. Constantinescu, P. Freitag, and L. Kappos Increase in serum levels of uric acid, an endogenous antioxidant, under treatment with glatiramer acetate for multiple sclerosis Mult. Scler. 6 2000 378 381