The role of the nuclear pore complex in aging of post-mitotic cells

Aging

Volumn 2, Issue 2, 2010, Pages 74-75

  Hetzer, Martin W ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

Aging; Intranuclear tubulin; Nuclear pore complex; Nucleoporin; Parkinson's disease

Indexed keywords

NUCLEOPORIN;

AGING; ANIMAL; ARTICLE; GENE EXPRESSION REGULATION; GENETICS; GENOME; HUMAN; MITOSIS; NUCLEAR PORE; PHYSIOLOGY;

AGING; ANIMALS; GENE EXPRESSION REGULATION; GENOME; HUMANS; MITOSIS; NUCLEAR PORE; NUCLEAR PORE COMPLEX PROTEINS;

EID: 77954661940     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100125     Document Type: Note

References (15)

1. D'Angelo MA and Hetzer MW. Structure, dynamics and function of nuclear pore complexes. Trends Cell Biol. 2008; 18:456-466.
2. D'Angelo MA, Raices M, Panowski SH, and Hetzer MW. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. Cell. 2009; 136:284-295.
3. Woulfe JM. Abnormalities of the nucleus and nuclear inclusions in neurodegenerative disease: a work in progress. Neuropathol Appl Neurobiol. 2007; 33:2-42.
4. Woulfe J, Gray D, Prichett-Pejic W, Munoz DG, and Chretien M. Intranuclear rodlets in the substantia nigra: interactions with marinesco bodies, ubiquitin, and promyelocytic leukemia protein. J Neuropathol Exp Neurol. 2004; 63:1200-1207.
5. Weis K. Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle. Cell. 2003; 112:441-451.
6. Alber F, Dokudovskaya S, Veenhoff LM, Zhang W, Kipper J, Devos D, Suprapto A, Karni-Schmidt O, Williams R, Chait BT, et al. The molecular architecture of the nuclear pore complex. Nature. 2007; 450:695-701.
7. Debler EW, Ma Y, Seo HS, Hsia KC, Noriega TR, Blobel G, and Hoelz A. A fence-like coat for the nuclear pore membrane. Mol Cell. 2008; 32:815-826.
8. Beck M, Forster F, Ecke M, Plitzko JM, Melchior F, Gerisch G, Baumeister W, and Medalia O. Nuclear pore complex structure and dynamics revealed by cryoelectron tomography. Science. 2004; 306:1387-1390.
9. Brohawn SG, Partridge JR, Whittle JR, and Schwartz TU. The nuclear pore complex has entered the atomic age. Structure. 2009; 17:1156-1168.
10. Weis K. Nucleocytoplasmic transport: cargo trafficking across the border. Curr Opin Cell Biol. 2002; 14:328-335.
11. Husseman JW, Nochlin D, and Vincent I. Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases. Neurobiol Aging. 2000; 21:815-828.
12. Chu CT, Plowey ED, Wang Y, Patel V, and Jordan-Sciutto KL. Location, location, location: altered transcription factor trafficking in neurodegeneration. J Neuropathol Exp Neurol. 2007; 66:873-883.
13. Poon IK and Jans DA. Regulation of nuclear transport: central role in development and transformation? Traffic. 2005; 6:173-186.
14. Korhonen P, Helenius M, and Salminen A. Age-related changes in the regulation of transcription factor NF-kappa B in rat brain. Neurosci Lett. 1997; 225:61-64.
15. Brown CR, Kenned, CJ, Delma, VA, Forbe, DJ, and Silve, PA. Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes. Genes Dev. 2008; 22:627-639.