Intravenous thrombolysis in patients with stroke attributable to small artery occlusion

European Journal of Neurology

Volumn 17, Issue 8, 2010, Pages 1054-1060

  Fluri, F ^a   Hatz, F ^a   Rutgers, M P ^b   Georgiadis, D ^c   Sekoranja, L ^d   Schwegler, G ^e   Sarikaya, H ^c   Weder, B ^f   Muller F ^g   Luthy R ^h   Arnold, M ⁱ   Reichhart, M ^b   Mattle, H P ⁱ   Tettenborn, B ^f   Nedeltchev, K ⁱ   Hungerbuhler H J ^e   Sztajzel, R ^d   Baumgartner, R W ^c   Michel, P ^b   Lyrer, P A ^a   Engelter, S T ^a   more..

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d University Hospital   (Switzerland)

^e University Hospital   (Switzerland)

^f CANTONAL HOSPITAL ST GALLEN   (Switzerland)

^g University Hospitals   (Germany)

^h TRIEMLI HOSPITAL   (Switzerland)

ⁱ Neurologische Universitatsklinik Bern   (Switzerland)

Author keywords

complications; etiology; outcome; small artery occlusion; stroke; thrombolysis

Indexed keywords

ALTEPLASE; FIBRINOLYTIC AGENT; TISSUE PLASMINOGEN ACTIVATOR;

ADULT; AGED; ARTERY DIAMETER; ARTICLE; BLOOD CLOT LYSIS; BRAIN ARTERY; BRAIN HEMORRHAGE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DRUG SAFETY; FEMALE; FIBRINOLYTIC THERAPY; FOLLOW UP; FUNCTIONAL ASSESSMENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; RANKIN SCALE; RECURRENT DISEASE; STROKE; TREATMENT OUTCOME; BRAIN ISCHEMIA; CHI SQUARE DISTRIBUTION; COMPLICATION; FACTUAL DATABASE; MIDDLE AGED; PERIPHERAL OCCLUSIVE ARTERY DISEASE; RISK; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ARTERIAL OCCLUSIVE DISEASES; BRAIN ISCHEMIA; CHI-SQUARE DISTRIBUTION; DATABASES, FACTUAL; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; RECURRENCE; STROKE; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME;

EID: 77954654762     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2010.02961.x     Document Type: Article

References (29)

1. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995 333 : 1581 1587.
2. Hacke W, Donnan G, Fieschi C, et al. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet 2004 363 : 768 774.
3. Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008 359 : 1317 1329.
4. Hsia AW, Sachdev HS, Tomlinson J, Hamilton SA, Tong DC. Efficacy of IV tissue plasminogen activator in acute stroke: does stroke subtype really matter? Neurology 2003 61 : 71 75.
5. Caplan LR, Mohr JP, Kistler JP, Koroshetz W. Should thrombolytic therapy be the first-line treatment for acute ischemic stroke? Thrombolysis - not a panacea for ischemic stroke N Engl J Med 1997 337 : 1309 1310.
6. Wardlaw JM, Zoppo G, Yamaguchi T, Berge E. Thrombolysis for acute ischaemic stroke. Cochrane Database Syst Rev 2003 3 : CD000213.
7. Lovett JK, Coull AJ, Rothwell PM. Early risk of recurrence by subtype of ischemic stroke in population-based incidence studies. Neurology 2004 62 : 569 573.
8. Petty GW, Brown RD Jr., Whisnant JP, et al. Ischemic stroke subtypes : a population-based study of functional outcome, survival, and recurrence. Stroke 2000 31 : 1062 1068.
9. Hwang YH, Seo JG, Lee HW, Park SP, Suh CK. Early neurological deterioration following intravenous recombinant tissue plasminogen activator therapy in patients with acute lacunar stroke. Cerebrovasc Dis 2008 26 : 355 359.
10. Cocho D, Belvis R, Marti-Fabregas J, et al. Does thrombolysis benefit patients with lacunar syndrome? Eur Neurol 2006 55 : 70 73.
11. Leys D, Englund E, Del ST, et al. White matter changes in stroke patients. Relationship with stroke subtype and outcome. Eur Neurol 1999 42 : 67 75.
12. Demchuk AM, Khan F, Hill MD, et al. Importance of leukoaraiosis on CT for tissue plasminogen activator decision making: evaluation of the NINDS rt-PA Stroke Study. Cerebrovasc Dis 2008 26 : 120 125.
13. Neumann-Haefelin T, Hoelig S, Berkefeld J, et al. Leukoaraiosis is a risk factor for symptomatic intracerebral hemorrhage after thrombolysis for acute stroke. Stroke 2006 37 : 2463 2466.
14. Norrving B. Leucoaraiosis and silent subcortical infarcts. Rev Neurol (Paris) 2008 164 : 801 804.
15. Adams HP Jr., del ZG, Alberts MJ, et al. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke 2007 38 : 1655 1711.
16. Engelter ST, Reichhart M, Sekoranja L, et al. Thrombolysis in stroke patients aged 80 years and older: Swiss survey of IV thrombolysis. Neurology 2005 65 : 1795 1798.
17. Engelter ST, Rutgers MP, Hatz F, et al. Intravenous thrombolysis in stroke attributable to cervical artery dissection. Stroke 2009 40 : 3772 3776.
18. Lyden P, Brott T, Tilley B, et al. Improved reliability of the NIH Stroke Scale using video training. NINDS TPA Stroke Study Group. Stroke 1994 25 : 2220 2226.
19. Adams HP Jr., Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993 24 : 35 41.
20. Ay H, Furie KL, Singhal A, et al. An evidence-based causative classification system for acute ischemic stroke. Ann Neurol 2005 58 : 688 697.
21. Kent DM, Selker HP, Ruthazer R, et al. The stroke-thrombolytic predictive instrument: a predictive instrument for intravenous thrombolysis in acute ischemic stroke. Stroke 2006 37 : 2957 2962.
22. Demchuk AM, Tanne D, Hill MD, et al. Predictors of good outcome after intravenous tPA for acute ischemic stroke. Neurology 2001 57 : 474 480.
23. Derex L, Hermier M, Adeleine P, et al. Clinical and imaging predictors of intracerebral haemorrhage in stroke patients treated with intravenous tissue plasminogen activator. J Neurol Neurosurg Psychiatry 2005 76 : 70 75.
24. Derex L, Nighoghossian N. Intracerebral haemorrhage after thrombolysis for acute ischaemic stroke: an update. J Neurol Neurosurg Psychiatry 2008 79 : 1093 1099.
25. Hill MD, Buchan AM. Thrombolysis for acute ischemic stroke: results of the Canadian Alteplase for Stroke Effectiveness Study. CMAJ 2005 172 : 1307 1312.
26. Engelter ST, Gostynski M, Papa S, jdacic-Gross V, Lyrer PA. Barriers to stroke thrombolysis in a geographically defined population. Cerebrovasc Dis 2007 23 : 211 215.
27. Kwan J, Hand P, Sandercock P. A systematic review of barriers to delivery of thrombolysis for acute stroke. Age Ageing 2004 33 : 116 121. (Pubitemid 38313108)
28. Kohrmann M, Nowe T, Huttner HB, et al. Safety and outcome after thrombolysis in stroke patients with mild symptoms. Cerebrovasc Dis 2009 27 : 160 166.
29. Featherstone RL, Brown MM, Coward LJ. International carotid stenting study: protocol for a randomised clinical trial comparing carotid stenting with endarterectomy in symptomatic carotid artery stenosis. Cerebrovasc Dis 2004 18 : 69 74.