A systematic review of barries to delivery of thrombolysis for acute stroke

Age and Ageing

Volumn 33, Issue 2, 2004, Pages 116-121

  Kwan, Joseph ^a   Hand, Peter ^b   Sandercock, Peter ^c  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

CVA; Hospital; Hospitalisation; Medical systems; Stroke; Thrombolytic therapy

Indexed keywords

ALTEPLASE; FIBRINOLYTIC AGENT; STREPTOKINASE;

ACCESS TO INFORMATION; AGED; AMBULANCE; BLOOD CLOT LYSIS; CEREBROVASCULAR ACCIDENT; CLINICAL OBSERVATION; CONTROLLED STUDY; EMBASE; EMERGENCY WARD; FIBRINOLYTIC THERAPY; GENERAL PRACTITIONER; HEALTH CARE DELIVERY; HOSPITAL ADMISSION; HUMAN; INFORMED CONSENT; MAJOR CLINICAL STUDY; MEDICAL LITERATURE; MEDICAL STAFF; MEDLINE; NEUROIMAGING; PARAMEDICAL PERSONNEL; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETROSPECTIVE STUDY; REVIEW; SYMPTOMATOLOGY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DIFFERENTIAL DIAGNOSIS; EMERGENCY HEALTH SERVICE; METHODOLOGY; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; STANDARD; TIME; TREATMENT OUTCOME;

CEREBROVASCULAR ACCIDENT; DIAGNOSIS, DIFFERENTIAL; HUMANS; PROSPECTIVE STUDIES; RANDOMIZED CONTROLLED TRIALS; RETROSPECTIVE STUDIES; RISK FACTORS; THROMBOLYTIC THERAPY; TIME FACTORS; TREATMENT OUTCOME; TRIAGE;

EID: 1542329665     PISSN: 00020729     EISSN: None     Source Type: Journal    
DOI: 10.1093/ageing/afh064     Document Type: Review

References (67)

1. Jones TH, Morawetz RB, Crowell RM et al. Thresholds of focal cerebral ischemia in awake monkeys. J Neurosurg 1981; 54: 773-82.
2. Adams HP Jr. Treating ischemic stroke as an emergency. Arch Neurol 1998; 55: 457-61.
3. Wardlaw JM, del Zoppo G, Yamaguchi T. Thrombolysis for acute ischaemic stroke (Cochrane systematic review). In The Cochrane Library, Issue 4. Oxford: Update Software, 2002.
4. Harraf F, Sharma AK, Brown MM, Lees KR, Vass RI, Kalra L. A multicentre observational study of presentation and early assessment of acute stroke. Br Med J 2002; 325: 17-20.
5. Azzimondi G, Bassein L, Fiorani L et al. Variables associated with hospital arrival time after stroke. Effect of delay on the clinical efficiency of early treatment. Stroke 1997; 28: 537-42.
6. Kothari R, Jauch E, Broderick J et al. Acute stroke: delays to presentation and emergency department evaluation. Ann Emerg Med 1999; 33: 3-8.
7. Wang XD, Guo H, Zhang XY, Zhu H, Li YH, Zhou G. An observation on the time of hospital arrival and correct diagnosis with CT in acute cerebral stroke patients. Cerebrovasc Dis 1997; 7: 89-93.
8. O'Connor RE, McGraw P, Edelsohn L. Thrombolytic therapy for acute ischemic stroke: why the majority of patients remain ineligible for treatment. Ann Emerg Med 1999; 33: 9-14.
9. Zweifler RM, Brody ML, Graves GC et al. Intravenous t-PA for acute ischaemic stroke: therapeutic yield of a code stroke system. Neurology 1998; 50: 501-3.
10. Sandercock P, Berge E, Dennis M et al. A systematic review of the effectiveness, cost-effectiveness and barriers to implementation of thrombolytic and neuroprotective therapy for acute ischaemic stroke in the NHS. Health Technol Assess 2002; 6: 1-112.
11. Jorgensen HS, Nakayama H, Reith J, Raaschou HO, Olsen TS. Factors delaying hospital admission in acute stroke. The Copenhagen Stroke Study. Neurology 1996; 47: 383-7.
12. Tilley BC, Lyden PD, Brott TG, Lu M, Levine SR, Welch KMA. Total quality improvement method for reduction of delays between emergency department admission and treatment of acute ischaemic stroke. Arch Neurol 1997; 54: 1466-74.
13. Feldmann F, Gorgon N, Brooks JM et al. Factors associated with early presentation of acute stroke. Stroke 1993; 24: 1805-10.
14. Lacy CR, Suh DC, Bueno M, Kostis JB. Delay in presentation and evaluation for acute stroke : Stroke Time Registry for Outcomes Knowledge and Epidemiology (S.T.R.O.K.E.). Stroke 2001; 32: 63-9.
15. Gomez CR, Malkoff MD, Sauer CM, Tulyapronchote R, Burch CM, Banet GA. Code stroke. An attempt to shorten inhospital therapeutic delays. Stroke 1994; 25: 1920-23.
16. Wester P, Radberg J, Lundgren B, Peltonen M. Factors associated with delayed admission to hospital and in-hospital delays in acute stroke and TIA: a prospective, multicenter study. Stroke 1999; 130: 40-8.
17. Streifler JY, Davidovitch S, Sendovski U. Factors associated with the time of presentation of acute stroke patients in an Israeli community hospital. Neuroepidemiology 1998; 17: 161-6.
18. Siu YC, Wong TW, Lau CC. Candidates for thrombolytic treatment in acute ischaemic stroke - where are our patients in Hong Kong? J Accid Emerg Med 1999; 16: 412-17.
19. Collins DR, O'Neill D, McCormack PME. Potential for treatment with thrombolysis in an Irish stroke unit. Irish Med J 1999; 192: 236-8.
20. Ferro JM, Melo TP, Oliveira V, Crespo M, Canhao P, Pinto AN. An analysis of the admission delay of acute strokes. Cerebrovasc Dis 1994; 4: 72-5.
21. Rasmussen BH, Germer U, Olsen TS. Acute stroke: dial 112 or call your "GP"? Eur J Neurol 2000; 7: 110 [Abstract P3018].
22. Fiorelli M, Falcon A, Sacchetti ML et al. The Rome emergency departments network for acute stroke: pilot study on incidence, referral pathways, and eligibility for thrombolytic therapy in Rome urban area. Ital J Neurol Sci 1999; 20: S137 [Abstract 173].
23. Ravindrane A, Croft-Baker J, Jarrett D, Severs MP. Causes of delay in hospital assessment after stroke. Age Ageing 2000; 29 (Suppl 2): 57.
24. Grond M, Stenzel C, Schumulling S et al. Early intravenous thrombolysis for acute ischaemic stroke in a community-based approach. Stroke 1998; 29: 1544-9.
25. Liu M, Fisher M, Yuan G, Zheng H. Early presentation of acute stroke in a Chinese population. Cerebrovasc Dis 1995; 5: 362-5.
26. Lin CS, Tsai J, Woo P, Chang H. Prehospital delay and emergency department management of ischemic stroke patients in Taiwan, R.O.C. Prehosp Emerg Care 1999; 3: 194-200.
27. Yoneda Y, Tabuchi M, Ohsumi Y et al. Pre- and in-hospital emergency systems for acute ischaemic stroke in a Japanese hospital. J Stroke Cerebrovasc Dis 2000; 9: 297-8.
28. Fogelholm R, Murros K, Rissanen A, Ilmavirta M. Factors delaying hospital admission after acute stroke. Stroke 1996; 27: 398-400.
29. Anderson NE, Broad JB, Bonita R. Delays in hospital admission and investigation in acute stroke. Br Med J 1995; 311: 162.
30. Bratina P, Greendberg L, Pasteur W, Grotta JC. Current emergency department management of stroke in Houston, Texas. Stroke 1995; 26: 409-14.
31. Casetta I, Granieri E, Gilli G, Laura G, Tola MR, Paolino E. Temporal trend and factors associated with delayed hospital admission of stroke patients. Neuroepidemiology 1999; 18: 255-64.
32. Lannehoa Y, Bouget J, Pinel JF, Garnier N, Leblanc JP, Branger B. Analysis of time management in stroke patients in three French emergency departments from stroke onset to computed tomography scan. Eur J Emerg Med 1999; 6: 95-103.
33. Mayer-Reichenauer M, Dachenhausen A, Bosak P et al. Prospective study of factors delaying admission to a stroke unit: the need for public education and training programmes for emergency physicians and paramedics. Cerebrovasc Dis 1998; 8: 35 [Abstract] CLI 43].
34. Morris DL, Rosamond W, Madden K, Schultz C, Hamilton S. Prehospital and emergency department delays after acute stroke : The Genentech Stroke Presentation Survey. Stroke 2000; 31: 2585-90.
35. Pistollato G, Ermani M. Time of hospital presentation after stroke. A multicenter study in north-east Italy. Ital J Neurol Sci 1996; 17: 401-7.
36. Rosamond WD, Gorton RA, Hinn AR, Hohenhaus SM, Morris DL. Rapid response to stroke symptoms: the Delay in Accessing Stroke Healthcare (DASH) Study. Acad Emerg Med 1998; 5: 45-51.
37. Hodgson C. Emergency management of acute ischaemic stroke in Canadian hospitals. CMAJ 1998; 159: S15-S18.
38. Morris DL, Rosamond W, Hinn AR, Gorton RA. Time delays in accessing stroke care in the emergency department. Acad Emerg Med 1999; 6: 218-23.
39. Charleston AJ, Barber PA, Bennett P, Spriggs DA, Harris RG, Anderson NE. Management of stroke in Auckland Hospital in 1996. N Z Med J 1999; 112: 71-4.
40. Salisbury HR, Banks BJ, Footitt DR, Winner SJ, Reynolds DJM. Delay in presentation of patients with acute stroke to hospital in Oxford. Q J Med 1998; 91: 635-40.
41. Smith MA, Doliszny KM, Shahar E, McGovern PG, Arnett DK, Luepker RV. Delayed hospital arrival for acute stroke: the Minnesota Stroke Survey. Ann Intern Med 1998; 129: 190-6.
42. Harper GD, Haigh RA, Potter JF, Castleden CM. Factors delaying hospital admission after stroke in Leicestershire. Stroke 1992; 23: 835-8.
43. Alberts MJ, Bertels C, Dawson DV. An analysis of time of presentation after stroke. JAMA 1990; 263: 65-8.
44. Biller J, Patrick JT, Shepard A, Adams HP. Delay time between onset of ischemic stroke and hospital arrival. J Stroke Cerebrovasc Dis 1993; 3: 228-30.
45. Kay R, Woo J, Poon WS. Hospital arrival time after onset of stroke. J Neurol Neurosurg Psychiatr 1992; 55: 973-4.
46. Duncan PW, Harrison DJ, Lai SM, Cook SF, Rymer MM. Factors affecting elapsed time between acute stroke and presentation. Stroke 2000; 31: 308 [Abstract P60].
47. Engelstein E, Margulies J, Jeret JS. Lack of t-PA use for acute ischaemic stroke in a community hospital: high incidence of exclusion criteria. Am J Emerg Med 2000; 18: 257-60.
48. Johnston F, Wardlaw J, Dennis MS et al. Delays in stroke referrals. Lancet 1999; 354: 47-48.
49. Schroeder EB, Rosamond WD, Morris DL, Evenson KR, Hinn AR. Determinants of use of emergency medical services in a population with stroke symptoms : the second Delay in Accessing Stroke Healthcare (DASH II) Study. Stroke 2000; 31: 2591-6.
50. Williams LS, Bruno A, Rouch D, Marriott DJ. Stroke patients' knowledge of stroke. Influence on time of presentation. Stroke 1997; 28: 912-15.
51. Menon SC, Pandey DK, Morgenstern LB. Critical factors determining access to acute stroke care. Neurology 1998; 51: 427-32.
52. Wein TH, Staub L, Felberg R et al. Activation of emergency medical services for acute stroke in a nonurban population: the T.L.L. Temple Foundation Stroke Project. Stroke 2000; 31: 1925-8.
53. Barsan WG, Brott TG, Broderick JP, Haley EC Jr., Levy DE, Marler JR. Urgent therapy for acute stroke. Effects of a stroke trial on untreated patients. Stroke 1994; 25: 2132-7.
54. Bartolini M, Ceravolo MG, Polonara S, Polonara G, Reginelli R, Provinciali L. Thrombolysis in ischemic stroke: evaluation of operative difficulties. Arch Gerontolgy Geriatr 1995; 20: 49-54.
55. Herderschee D, Limburg M, Hijdra A, Bollen A, Pluvier J, te Water W. Timing of hospital admission in a prospective series of stroke patients. Cerebrovasc Dis 1991; 1: 165-7.
56. Andre C, Moraes-Neto BM, Novis SAP. Experience with t-PA treatment in a large south American city. J Stroke Cerebrovasc Dis 1998; 7: 255-8.
57. Malik MM, Gomez CR, Tulyapronchote R, Malkoff MD, Bandlamudi R, Banet GA. Delay between emergency room arrival and stroke consultation. J Stroke Cerebrovasc Dis 1993; 3: 177-80.
58. Villar-Cordova C, Morgenstern LB, Barnholtz JS, Frankowski RF, Grotta JC. Neurologists' attitudes regarding rt-PA for acute ischemic stroke. Neurology 1998; 50: 1491-4.
59. Kothari R, Barsan W, Brott T, Broderick J, Ashbrock S. Frequency and accuracy of prehospital diagnosis of acute stroke. Stroke 1995; 26: 937-41.
60. Bornstein N, Karepov VG. A call for improvement in prehospital stroke identification. Stroke 2000; 31: 309 [Abstract P65].
61. Chiu D, Krieger D, Villar-Cordova C et al. Intravenous tissue plasminogen activator for acute ischaemic stroke. Feasibility, safety, and efficacy in the first year of clinical practice. Stroke 1998; 29: 18-22.
62. Evenson KR, Rosamond W, Morris DL. Prehospital and in-hospital delays in acute stroke care. Neuroepidemiology, 2001; 20: 65-76.
63. Gorelick PB, Sacco RL, Smith DB et al. Prevention of a first stroke: a review of guidelines and a multidisciplinary consensus statement from the National Stroke Association. JAMA 1999; 281: 1112-20.
64. Weltermann BM, Rogalewski A, Homann J et al. Knowledge about stroke among the German population. Dtsch Med Wochenschr 2000; 125: 416-20.
65. Kaste M, Skyhoj OT, Orgogozo J, Bogousslavsky J, Hacke W. Organization of stroke care: education, stroke units and rehabilitation. European Stroke Initiative (EUSI). Cerebrovasc Dis 2000; 10 (Suppl 3): 1-11.
66. Kaste M. Thrombolysis in ischaemic stroke - present and future: role of combined therapy. Cerebrovasc Dis 2001; 11 (Suppl 1): 55-9.
67. Morgenstern LB, Staub L, Chan W et al. Improving delivery of acute stroke therapy: The TLL Temple Foundation Stroke Project. Stroke 2002; 33: 160-6.