Importance of leukoaraiosis on CT for tissue plasminogen activator decision making: Evaluation of the NINDS rt-PA stroke study

Cerebrovascular Diseases

Volumn 26, Issue 2, 2008, Pages 120-125

  Demchuk, Andrew M ^a   Khan, Firosh ^a   Hill, Michael D ^a   Barber, Philip A ^a   Silver, Brian ^b   Patel, Suresh ^b   Levine, Steven R ^c  

^a UNIVERSITY OF CALGARY   (Canada)

^b HENRY FORD HOSPITAL   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Leukoaraiosis; Thrombolysis; Thrombolytic therapy

Indexed keywords

ALTEPLASE; PLACEBO;

ARTICLE; BLOOD VESSEL DIAMETER; BRAIN ANGIOGRAPHY; BRAIN CORTEX; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; HEALTH CARE ORGANIZATION; HUMAN; LEUKOARAIOSIS; MAJOR CLINICAL STUDY; MEDICAL DECISION MAKING; MICROANGIOGRAPHY; MULTICENTER STUDY; NEUROIMAGING; NEUROLOGIC EXAMINATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RANKIN SCALE; RISK ASSESSMENT; SCORING SYSTEM; TREATMENT OUTCOME; WHITE MATTER;

DECISION MAKING; FIBRINOLYTIC AGENTS; HUMANS; INFUSIONS, INTRAVENOUS; INTRACRANIAL HEMORRHAGES; LEUKOARAIOSIS; LOGISTIC MODELS; MULTICENTER STUDIES AS TOPIC; PATIENT SELECTION; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RECOMBINANT PROTEINS; RETROSPECTIVE STUDIES; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; STROKE; THROMBOLYTIC THERAPY; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME;

EID: 49949111534     PISSN: 10159770     EISSN: None     Source Type: Journal    
DOI: 10.1159/000139658     Document Type: Article

References (33)

1. Hachinski VC, Potter P, Merskey H: Leukoaraiosis. Arch Neurol 1987;44:21-23.
2. Gorter JW, Stroke Prevention in Reversible Ischemia Trial (SPIRIT) and European Atrial Fibrillation Trial (EAFT) Study Groups: Major bleeding during anticoagulation after cerebral ischemia: patterns and risk factors. Neurology 1999;53:1319-1327.
3. Smith EE, Rosand J, Knudsen KA, Hylek EM, Greenberg SM: Leukoaraiosis is associated with warfarin-related hemorrhage following ischemic stroke. Neurology 2002;59:193-197.
4. Kidwell CS, Saver JL, Villablanca P, Duckwiler G, Fredieu A, Gough K, Leary MC, Starkman S, Gobin YP, Jahan R, Vespa P, Liebeskind DS, Alger JR, Vinuela F: Magnetic resonance imaging detection of microbleeds before thrombolysis: an emerging application. Stroke 2002;33:95-98.
5. Coutts S, Frayne R, Sevick R, Demchuk A: Microbleeding on MRI as a marker for hemorrhage after stroke thrombolysis. Stroke 2002;33:1457-1458.
6. Winkler DT, Biedermann L, Tolnay M, Allegrini PR, Staufenbiel M, Wiessner C, Jucker M: Thrombolysis induces cerebral hemorrhage in a mouse model of cerebral amyloid angiopathy. Ann Neurol 2002;51:790-793.
7. 2*-weighted MRI: correlation with stroke subtype, stroke recurrence, and leukoaraiosis. Stroke 2002;1536-1540.
8. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group: Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995;333:1581-1587.
9. The NINDS tPA Stroke Study Group: Generalized efficacy of tPA for acute stroke: subgroup analysis of the NINDS tPA Stroke Trial. Stroke 1997;28:2119-2125.
10. Patel SC, Levine SR, Tilley BC, Grotta JC, Lu M, Frankel M, Haley EC Jr, Brott TG, Broderick JP, Horowitz S, Lyden PD, Lewandowski CA, Marler JR, Welch KMA: Lack of clinical significance of early ischemic changes on computed tomography in acute stroke. JAMA 2001;286:2830-2838.
11. Van Swieten JC, Hijdra A, Koudstaal PJ, van Gijn J: Grading white matter lesions on CT and MRI: a simple scale. J Neurol Neurosurg Psychiatry 1990;53:1080-1083.
12. Fiorelli M, Di Piero V, Vicenzini E, Tombari D, Romano A, Lenzi GL, Bozzao L, Meier D, Wunderlich O, von Kummer R: Leukoaraiosis was not associated with an increased risk of parenchymal hemorrhage in the combined ECASS 1-ECASS 2 cohort (abstract). Stroke 2002;33:382.
13. Brott T, Adams HP, Olinger CP, Marler JR, Barsan WG, Biller J, Spilker J, Holleran R, Eberle R, Hertzberg V: Measurements of acute cerebral infarction: a clinical examination scale. Stroke 1989;20:864-870.
14. Mahoney FI, Barthel DW: Functional evaluation: the Barthel index. Md Med J 1965;14:61-65.
15. Van Swieten JC, Koudstaal PJ, Visser MC, Schouten HJ, van Gijn J: Interobserver agreement for the assessment of handicap in stroke patients. Stroke 1988;19:604-607.
16. Teasdale G, Knill-Jones R, Van der Sande J: Observer variability in assessing impaired consciousness and coma. J Neurol Neurosurg Psychiatry 1978;41:603-610.
17. Demchuk AM, Hill MD, Barber PA, Silver B, Patel S, Levine SR: Importance of CT early ischemic change using ASPECTS in NINDS rt-PA Study. Stroke 2005;36:2110-2115.
18. Liao D, Cooper L, Cai J, Toole JF, Bryan NR, Hutchinson RG, Tyroler HA: Presence and severity of cerebral white matter lesions and hypertension, its treatment, and its control. The ARIC Study. Stroke 1996;27:2262-2270.
19. Streifler JY, Eliasziw M, Benavente OR, Alamowitch S, Fox AJ, Hachinski VC, Barnett HJ: Prognostic importance of leukoaraiosis in patients with symptomatic internal carotid artery stenosis. Stroke 2002;33:1651-1655.
20. Inzitari D, Cadelo M, Marranci ML, Pracucci G, Pantoni L: Vascular deaths in elderly neurological patients with leukoaraiosis. J Neurol Neurosurg Psychiatry 1997;62:177-181.
21. Dufouil C, Chalmers J, Coskun O, Besancon V, Bousser MG, Guillon P, MacMahon S, Mazoyer B, Neal B, Woodward M, Tzourio-Mazoyer N, Tzourio C, PROGRESS MRI Substudy Investigators: Effects of blood pressure lowering on cerebral white matter hyperintensities in patients with stroke: the PROGRESS (Perindopril Protection against Recurrent Stroke Study) magnetic resonance imaging substudy. Circulation 2005;112:1644-1650.
22. Wallin A, Sjogren M, Edman A, Blennow K, Regland B: Symptoms, vascular risk factors and blood-brain barrier function in relation to CT white matter changes in dementia. Eur Neurol 2000;44:229-235.
23. Ma KC, Olsson Y: The role of chronic brain edema in the formation of lacunes in Binswanger's encephalopathy. Cerebrovasc Dis 1997;7:324-331.
24. Schmidt R, Schmidt H, Fazekas F, Schumacher M, Niederkorn K, Kapeller P, Weinrauch V, Kostner GM: Apolipoprotein E polymorphism and silent microangiopathy-related cerebral damage: results of the Austrian Stroke Prevention Study. Stroke 1997;28:951-956.
25. Szolnoki Z, Somogyvari F, Kondacs A, Szabo M, Fodor L: Evaluation of the roles of common genetic mutations in leukoaraiosis. Acta Neurol Scand 2001;104:281-287.
26. Chabriat H, Joutel A, Vahedi K, Iba-Zizen MT, Tournier-Lasserve E, Bousser MG: CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). J Mal Vasc 1996;21:277-282.
27. 2*-weighted magnetic resonance imaging study. Neurosci Lett 2003;340:213-216.
28. 2*-weighted brain MRI study. Stroke 2002;33:735-742.
29. Kidwell CS, Saver JL, Villablanca P, Duckwiler G, Fredieu A, Gough K, Leary MC, Starkman S, Gobin YP, Jahan R, Vespa P, Liebeskind DS, Alger JR, Vinuela F: Magnetic resonance imaging detection of microbleeds before thrombolysis: an emerging application. Stroke 2002;33:95-98.
30. Coutts S, Frayne R, Sevick R, Demchuk A: Microbleeding on MRI as a marker for hemorrhage after stroke thrombolysis. Stroke 2002;33:1457-1458.
31. 2*-weighted magnetic resonance imaging data from 570 patients. Stroke 2007;38:2738-2744.
32. Palumbo V, Boulanger JM, Hill MD, Inzitari D, Buchan AM: Leukoaraiosis and intracerebral hemorrhage after thrombolysis in acute stroke. Neurology 2007;68:1020-1024.
33. Neumann-Haefelin T, Hoelig S, Berkefeld J, Fiehler J, Gass A, Humpich M, Kastrup A, Kucinski T, Lecei O, Liebeskind DS, Rother J, Rosso C, Samson Y, Saver JL, Yan B, MR Stroke Group: Leukoaraiosis is a risk factor for symptomatic intracerebral hemorrhage after thrombolysis for acute stroke. Stroke 2006;37:2463-2466.