A proteomics-based translational approach reveals an antifolate resistance inherent in human plasma derived from blood donation

Journal of Proteome Research

Volumn 9, Issue 6, 2010, Pages 3091-3102

  Chin, Li Te ^a,b   Huang, Pei Ru ^c   Hu, Kuang Yu ^b   Huang, Nai Kuei ^d   Chiu, Cheng Di ^b,d   Hour, Ai Ling ^c   Shui, Hao Ai ^b   Chu, Chi Hong ^e   Chen, Han Min ^c  

^a National Chiayi University   (United States)

^b National Defense Medical Center   (United States)

^c FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^d Taichung Hospital   (Taiwan)

^e Tri Service General Hospital   (China)

Author keywords

adenine; antifolates; proteomics; systems biology

Indexed keywords

ADENINE; BIOLOGICAL MARKER; DNA; METHOTREXATE;

ANIMAL CELL; ARTICLE; BLOOD COMPONENT; BLOOD TRANSFUSION; CELL PROLIFERATION; CELL SURVIVAL; CLUSTER ANALYSIS; CONTROLLED STUDY; CYTOTOXICITY; ERYTHROCYTE PRESERVATION; HUMAN; IN VITRO STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; SYSTEMS BIOLOGY; THERMOSTABILITY; UPREGULATION;

ADENINE; AMINOPTERIN; ANIMALS; BLOOD PRESERVATION; BLOOD PROTEINS; BLOOD TRANSFUSION; CELL LINE, TUMOR; CELL PROLIFERATION; CLUSTER ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; DRUG STABILITY; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FOLIC ACID ANTAGONISTS; HUMANS; KAPLAN-MEIER ESTIMATE; METHOTREXATE; MICE; PRESERVATIVES, PHARMACEUTICAL; PROTEOMICS; RETROSPECTIVE STUDIES; SYSTEMS BIOLOGY; UP-REGULATION;

MURINAE;

EID: 77954606783     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr100005u     Document Type: Article

References (61)

1. Voet, D. J.; Voet, J. G.; C. W., P. Principles of Biochemistry; 3rd ed.; John Wiley & Sons, Inc.: Hoboken, NJ, 2008.
2. Monahan, B. P.; Allegra, C. J. Antifolates. In Cancer Chemotherapy and Biotherapy, 4th ed.; Chabner, B. A., Longo, D. L., Eds.; Lippincott Williams & Wilkins: Philadelphia, PA, 2005; p 91.
3. Farber, S. Some observations on the effect of folic acid antagonists on acute leukemia and other forms of incurable cancer. Blood 1949, 4 (2), 160-167.
4. Farber, S.; Diamond, L. K. Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroylglutamic acid. N. Engl. J. Med. 1948, 238 (23), 787-793.
5. Robert, F. Trimetrexate as a single agent in patients with advanced head and neck cancer. Semin. Oncol. 1988, 15 (2 Suppl. 2), 22-26.
6. Maroun, J. A.; Natale, R. B.; Robert, F. Trimetrexate combined with cisplatin or etoposide in the treatment of non-small cell lung cancer: a pilot study. Semin. Oncol. 1988, 15 (2 Suppl. 2), 38-40.
7. Tienghi, A.; Rosti, G.; Fiorentini, G. M.; Turci, D.; Cruciani, G.; Marangolo, M. Modulated chemo-hormonotherapy in advanced breast cancer. A pilot study. Chemioterapia 1986, 5 (1), 61-65.
8. Aisner, J.; Whitacre, M.; Van Echo, D. A.; Wiernik, P. H. Combination chemotherapy for small cell carcinoma of the lung: continuous versus alternating non-cross-resistant combinations. Cancer Treat. Rep. 1982, 66 (2), 221-230.
9. Odujinrin, O. O.; DeConti, R. C.; Bertino, J. R. Combination chemotherapy with cyclophosphamide (NSC-26271), cytosine arabinoside (NSC-63878), and methotrexate (NSC-740) in advanced solid tumors. Cancer Chemother. Rep. 1975, 59 (6), 1091-1096.
10. Hoffmeister, R. T. Methotrexate therapy in rheumatoid arthritis: 15 years experience. Am. J. Med. 1983, 75 (6A), 69-73.
11. Rees, R. B.; Bennett, J. H.; Maibach, H. I.; Arnold, H. L. Methotrexate for psoriasis. Arch. Dermatol. 1967, 95 (1), 2-11.
12. Arulkumaran, S.; Ng, C. S.; Ingemarsson, I.; Ratnam, S. S. Medical treatment of placenta accreta with methotrexate. Acta Obstet. Gynecol. Scand. 1986, 65 (3), 285-286.
13. Calabresi, P.; Chabner, B. A. Chemotherapy of neoplstic disease. In The Pharmacologic Basis of Therapeutics., 8th ed.; Gilman, A. G., Rall, T. W., Nies, D. S., Taylor, P., Eds.; Pergamon Press: New York, 1990; p 1202.
14. Allegra, C. J.; Chabner, B. A.; Tuazon, C. U.; Ogata-Arakaki, D.; Baird, B.; Drake, J. C.; Simmons, J. T.; Lack, E. E.; Shelhamer, J. H.; Balis, F.; et al. Trimetrexate for the treatment of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome. N. Engl. J. Med. 1987, 317 (16), 978-985.
15. Antony, A. C. The biological chemistry of folate receptors. Blood 1992, 79 (11), 2807-2820.
16. Assaraf, Y. G. Molecular basis of antifolate resistance. Cancer Metastasis Rev. 2007, 26 (1), 153-181.
17. Assaraf, Y. G.; Goldman, I. D. Loss of folic acid exporter function with markedly augmented folate accumulation in lipophilic antifolate-resistant mammalian cells. J. Biol. Chem. 1997, 272 (28), 17460-17466.
18. Takemura, Y.; Kobayashi, H.; Miyachi, H. Cellular and molecular mechanisms of resistance to antifolate drugs: new analogues and approaches to overcome the resistance. Int. J. Hematol. 1997, 66 (4), 459-477.
19. Assaraf, Y. G. The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis. Drug Resist. Updates 2006, 9 (4-5), 227-246.
20. Assaraf, Y. G. The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis. Drug Resist. Updates 2006, 9 (4-5), 227-246.
21. Volk, E. L.; Schneider, E. Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003, 63 (17), 5538-5543.
22. Nair, B. M.; Cheung, K. J., Jr.; Griffith, A.; Burns, J. L. Salicylate induces an antibiotic efflux pump in Burkholderia cepacia complex genomovar III (B. cenocepacia). J. Clin. Invest. 2004, 113 (3), 464-473.
23. Freshney, R. I. Culture of Animal Cells, A Manual of Basic Technique., 4th ed.; Wiley-Liss: New York, 2000.
24. Lin, C. Y.; Wang, V.; Shui, H. A.; Juang, R. H.; Hour, A. L.; Chen, P. S.; Huang, H. M.; Wu, S. Y.; Lee, J. C.; Tsai, T. L.; Chen, H. M. A comprehensive evaluation of imidazole-zinc reverse stain for current proteomic researches. Proteomics 2009, 9 (3), 696-709.
25. Inohara, N.; Ding, L.; Chen, S.; Nunez, G. harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L). EMBO J. 1997, 16 (7), 1686-1694.
26. Welburn, S. C.; Murphy, N. B. Prohibitin and RACK homologues are up-regulated in trypanosomes induced to undergo apoptosis and in naturally occurring terminally differentiated forms. Cell Death Differ. 1998, 5 (7), 615-622.
27. Stebbins, C. E.; Russo, A. A.; Schneider, C.; Rosen, N.; Hartl, F. U.; Pavletich, N. P. Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent. Cell 1997, 89 (2), 239-250.
28. Berens, R. L.; Marr, J. J.; LaFon, S. W.; Nelson, D. J. Purine metabolism in Trypanosoma cruzi. Mol. Biochem. Parasitol. 1981, 3 (3), 187-196.
29. Matias, C.; Nott, S. E.; Bagnara, A. S.; O'Sullivan, W. J.; Gero, A. M. Purine salvage and metabolism in Babesia bovis. Parasitol. Res. 1990, 76 (3), 207-213.
30. Molnar, J. Adenine nucleotide synthesis and growth rate of the adenyl succinate lyase mutant of Bacillus anthracis. Acta Microbiol. Acad. Sci. Hung. 1975, 22 (3), 285-289.
31. Brown, A. K.; Raeside, D. L.; Bowditch, J.; Dow, J. W. Metabolism and salvage of adenine and hypoxanthine by myocytes isolated from mature rat heart. Biochim. Biophys. Acta 1985, 845 (3), 469-476.
32. Cumaraswamy, A.; Henney, H. R., Jr. Adenine salvage enzymes and intracellular nucleotide triphosphate content in Physarum flavicomum amoebae during growth and development. Canadian J. Microbiol. 1989, 35 (5), 554-558.
33. Bowen, T. L.; Whitman, W. B. Incorporation of exogenous purines and pyrimidines by methanococcus voltae and isolation of analogresistant mutants. Appl. Environ. Microbiol. 1987, 53 (8), 1822-1826.
34. Tamagaki, K.; Yuan, Q.; Ohkawa, H.; Imazeki, I.; Moriguchi, Y.; Imai, N.; Sasaki, S.; Takeda, K.; Fukagawa, M. Severe hyperparathyroidism with bone abnormalities and metastatic calcification in rats with adenine-induced uraemia. Nephrol., Dial., Transplant. 2006, 21 (3), 651-659.
35. Ogirima, T.; Tano, K.; Kanehara, M.; Gao, M.; Wang, X.; Guo, Y.; Zhang, Y.; Guo, L.; Ishida, T. Sex difference of adenine effects in rats: renal function, bone mineral density and sex steroidogenesis. Endocr. J. 2006, 53 (3), 407-413.
36. Fukuwatari, T.; Morikawa, Y.; Hayakawa, F.; Sugimoto, E.; Shibata, K. Influence of adenine-induced renal failure on tryptophan-niacin metabolism in rats. Biosci. Biotechnol. Biochem. 2001, 65 (10), 2154-2161.
37. Gorzalka, S.; Vittori, S.; Volpini, R.; Cristalli, G.; von Kugelgen, I.; Muller, C. E. Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues. Mol. Pharmacol. 2005, 67 (3), 955-964.
38. Barrat, F. J.; Cua, D. J.; Boonstra, A.; Richards, D. F.; Crain, C.; Savelkoul, H. F.; de Waal-Malefyt, R.; Coffman, R. L.; Hawrylowicz, C. M.; O'Garra, A. In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)-and Th2-inducing cytokines. J. Exp. Med. 2002, 195 (5), 603-616.
39. Zhang, X.; Li, P.; Bao, J.; Nicosia, S. V.; Wang, H.; Enkemann, S. A.; Bai, W. Suppression of death receptor-mediated apoptosis by 1,25- dihydroxyvitamin D3 revealed by microarray analysis. J. Biol. Chem. 2005, 280 (42), 35458-35468.
40. Thompson, C. J.; Tam, N. N.; Joyce, J. M.; Leav, I.; Ho, S. M. Gene expression profiling of testosterone and estradiol-17 beta-induced prostatic dysplasia in Noble rats and response to the antiestrogen ICI 182,780. Endocrinology 2002, 143 (6), 2093-2105.
41. Smyth, M. J.; Kelly, J. M.; Sutton, V. R.; Davis, J. E.; Browne, K. A.; Sayers, T. J.; Trapani, J. A. Unlocking the secrets of cytotoxic granule proteins. J. Leukocyte Biol. 2001, 70 (1), 18-29.
42. Liu, H.; Miller, E.; van de Water, B.; Stevens, J. L. Endoplasmic reticulum stress proteins block oxidant-induced Ca2+ increases and cell death. J. Biol. Chem. 1998, 273 (21), 12858-12862.
43. Andrin, C.; Pinkoski, M. J.; Burns, K.; Atkinson, E. A.; Krahenbuhl, O.; Hudig, D.; Fraser, S. A.; Winkler, U.; Tschopp, J.; Opas, M.; Bleackley, R. C.; Michalak, M. Interaction between a Ca2+-binding protein calreticulin and perforin, a component of the cytotoxic T-cell granules. Biochemistry 1998, 37 (29), 10386-10394.
44. Garcia-Nogales, P.; Almeida, A.; Bolanos, J. P. Peroxynitrite protects neurons against nitric oxide-mediated apoptosis. A key role for glucose-6-phosphate dehydrogenase activity in neuroprotection. J. Biol. Chem. 2003, 278 (2), 864-874.
45. Hippe, H. J.; Lutz, S.; Cuello, F.; Knorr, K.; Vogt, A.; Jakobs, K. H.; Wieland, T.; Niroomand, F. Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Specific activation of Gsalpha by an NDPK B.Gbetagamma complex in H10 cells. J. Biol. Chem. 2003, 278 (9), 7227-7233.
46. Yap, A. K.; Jani, J. J.; Luscombe, D. K. Methotrexate toxicity coincident with packed red cell transfusions. Lancet 1986, 2 (8507), 641.
47. Olah, M. E.; Stiles, G. L. The role of receptor structure in determining adenosine receptor activity. Pharmacol. Ther. 2000, 85 (2), 55-75.
48. Flavin, M.; Graff, S. The utilization of adenine for nucleic acid biosynthesis by Tetrahymena geleii. J. Biol. Chem. 1951, 192 (2), 485-488.
49. Sugita, Y.; Simon, E. R. The Mechanism of Action of Adenine in Red Cell Preservation. J. Clin. Invest. 1965, 44, 629-642.
50. Natsumeda, Y.; Prajda, N.; Donohue, J. P.; Glover, J. L.; Weber, G. Enzymic capacities of purine de Novo and salvage pathways for nucleotide synthesis in normal and neoplastic tissues. Cancer Res. 1984, 44 (6), 2475-2479.
51. Natsumeda, Y.; Lui, M. S.; Emrani, J.; Faderan, M. A.; Reardon, M. A.; Eble, J. N.; Glover, J. L.; Weber, G. Purine enzymology of human colon carcinomas. Cancer Res. 1985, 45 (6), 2556-2559.
52. Ikegami, T.; Natsumeda, Y.; Weber, G. Decreased concentration of xanthine dehydrogenase (EC 1.1.1.204) in rat hepatomas. Cancer Res. 1986, 46 (8), 3838-3841.
53. Natsumeda, Y.; Ikegami, T.; Weber, G. Purine synthetic capacities of de novo and salvage pathways in rat hepatoma 3924A cells. Adv. Exp. Med. Biol. 1986, 195, 371-376.
54. Weber, G.; Jayaram, H. N.; Pillwein, K.; Natsumeda, Y.; Reardon, M. A.; Zhen, Y. S. Salvage pathways as targets of chemotherapy. Adv. Enzyme Regul. 1987, 26, 335-352.
55. Weber, G.; Jayaram, H. N.; Lapis, E.; Natsumeda, Y.; Yamada, Y.; Yamaji, Y.; Tricot, G. J.; Hoffman, R. Enzyme-pattern-targeted chemotherapy with tiazofurin and allopurinol in human leukemia. Adv. Enzyme Regul. 1988, 27, 405-433.
56. Natsumeda, Y.; Ikegami, T.; Olah, E.; Weber, G. Significance of purine salvage in circumventing the action of antimetabolites in rat hepatoma cells. Cancer Res. 1989, 49 (1), 88-92.
57. Peck, C. C.; Moore, G. L.; Bolin, R. B. Adenine in blood preservation. Crit. Rev. Clin. Lab. Sci. 1981, 13 (3), 173-212.
58. Marlewski, M.; Smolenski, R. T.; Laurence, A.; Simmonds, H. A.; Swierczynski, J. Evaluation of adenine concentration in plasma of patients with renal failure using improved ultrafiltration technique. Clin. Biochem. 1997, 30 (1), 268-268
59. Shaprio, R. The prebiotic role of adenine: A critical analysis. Origins Life Evol. Biospheres 1995, 25 (1-3), 83-98.
60. Borsi, J. D.; Sagen, E.; Romslo, I.; Moe, P. J. Rescue after intermediate and high-dose methotrexate: background, rationale, and current practice. Pediatr. Hematol. Oncol. 1990, 7 (4), 347-363.
61. Isacoff, W. H.; Townsend, C. M.; Eiber, F. R.; Forster, T.; Morton, D. L.; Block, J. B. High dose methotrexate therapy of solid tumors: observations relating to clinical toxicity. Med. Pediatr. Oncol. 1976, 2 (3), 319-325.