Effect of lamotrigine and environmental enrichment on spatial memory and other behavioral functions in rats

Arzneimittel-Forschung/Drug Research

Volumn 60, Issue 6, 2010, Pages 307-314

  Nowakowska, Elzbieta ^a   Czubak, Anna ^a   Kus, Krzysztof ^a   Metelska, Jana ^a   Burda, Kinga ^a   Nowakowska, Anna ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Antiepileptics; CAS 84057 84 1; Enriched environment; Lamotrigine, antidepressant effect; Spatial memory

Indexed keywords

LAMOTRIGINE; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; TRIAZINE DERIVATIVE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; COGNITION; CONTROLLED STUDY; DEPRESSION; DOSE TIME EFFECT RELATION; DRUG EFFECT; ENVIRONMENTAL ENRICHMENT; EPILEPSY; FORCED SWIMMING TEST; IMMOBILIZATION; LEARNING; LOCOMOTION; MALE; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; OUTCOME ASSESSMENT; RAT; SINGLE DRUG DOSE; SPATIAL MEMORY; STATISTICAL SIGNIFICANCE; TREATMENT DURATION; TREATMENT RESPONSE; ANIMAL; DEPTH PERCEPTION; DRUG ADMINISTRATION; DRUG EFFECTS; MAZE TEST; MEMORY; WISTAR RAT;

ANIMALS; ANTICONVULSANTS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; DRUG ADMINISTRATION SCHEDULE; MALE; MAZE LEARNING; MEMORY; RATS; RATS, WISTAR; SPACE PERCEPTION; TRIAZINES;

EID: 77954597604     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296292     Document Type: Article

References (58)

1. Aldenkamp AP, Baker G. A systematic review of the effects of lamotrigine on cognitive function and quality of life. Epilepsy Behav. 2001;2:85-91. (Pubitemid 33585774)
2. Alonso R, Griebel G, Pavone G, Stemmelin J, Le FG, Soubrie P. Blockade of CRF(1) or V(1b) receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression. Mol. Psychiatry. 2004; 9:278-86.
3. Balu DT, Lucki I. Adult hippocampal neurogenesis: Regulation, functional implications, and contribution to disease pathology. Neurosci Behav Rev. 2009;33:232-52.
4. Boisser JR, Tardy J, Diverres JC. Ue nouvelle methode simple pour explorer l'action tranquilisante: le test de la cheminee. Med Exp. 1960;3:81-4.
5. Bourin M, Masse F, Hascoet M. Evidence for the activity of lamotrigine at 5-HT1A receptors in the mouse forced swimming test. J Psychiatry Neurosci. 2005;30(4):275-82.
6. Bourin M, Prica C. The role of mood stabilizers in the treatment of the depressive facet of bipolar disorders. Neurosci Biobehav Rev. 2007;31(6):963-75.
7. Bowden Cl, Mitchell P, Suppes T. Lamotrigine in the treatment of bipolar depression. Eur Neuropsychopharmacol. 1999;9:113-7.
8. Bowden CL. New concepts in mood stabilization: evidence for the effectiveness of valproate and lamotrigine. Neuropsychopharmacology. 1998;19:194-9.
9. Brodie MJ, Schachter SC. Epilepsy. Oxford: Health Press; 2001.
10. Consoni FT, Vital MA, Andreatini R. Dual monoamine modulation for the antidepressant like effect of lamotrigine in the modified forced swimming test. Eur Neuropsychopharmacol. 2006;16:451-8.
11. Faverjon S, Silveira DC, Fu DD, Cha BH, Akman C, Hu Y, et al. Beneficial effects of enriched environment following status epilepticus in immature rats. Neurology. 2002;59(9):1302-3.
12. Ghaemi SN, Gaughan S. Novel anticonvulsants: a new generation of mood stabilizers. Harvard Rev Psychiatry. 2000;8:1-7.
13. Halogen T, Nissinen Jari, Pitkanen A. Effect of lamotrigine treatment on status epilepticus-induced neuronal damage and memory impartment in rat. Epilepsy Res . 2001;46:205-23.
14. Hattori S, Hashimoto R, Miyakawa T. Enriched enviroments influence depression-related behavior in adult mice and the survival of newborn cells in their hippocampi. Behav Brain Res. 2007;180:69-76.
15. Holmes GL, Gaiarsa JL, Chevassus-Au-Louis N, Ben-Ari Y. Consequences of neonatal seizures in the rat: morphological and behavioral effect. Ann Neurol. 1998;44:845-57.
16. Jedynak P, Jaholkowski P, Filipkowski RK. Neurogeneza doroslych a depresja. Neuropsychiatry Neuropsychol. 2007;2:57-65.
17. + channels in rat hippocampal neurons. Br J Pharmacol. 1997;121:1231-8.
18. Leach MJ, Marden CM, Miller AA. Pharmacological studies of lamotrigine, a novel potential antipsychotic drug: II neurochemical, and clinical studies of the mechanism of action. Epilepsia. 1986;27:490-7.
19. Lizasoain I, Knowles RG, Monada S. Inhibition by lamotrigine of the generation of nitric oxide in rat forebrain slices. J Neurochem. 1995;64(2):636-42.
20. Longo R, Domenici MR, de Carolis S, Sagratella S. Falbamate selectively blocks in vitro hippocampal kainate-induced irreversible electrical changes. Life Sci. 1995;56(21):409-14.
21. Loscher W. Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs: a comparison of the pharmacology of kindling and post status epilepticus models of temporal lobe epilepsy. Epilepsy Res. 2002;50:105-23.
22. Luszczki JJ, Sielski M, Kominek M, Swiader MJ. Effect of lamotrigine combined with tiagabine on locomotor activity in mice. Ann Universitatis Marie Curie-Sklodowska, Lublin, Polonia Sectio D. 2006:2;167.
23. Luszczki JJ. Effects of lamotrigine alone or in combination with conventional antiepileptic drugs on locomotor activity in mice. Ind J Pharmacol. 2004;36;306-11.
24. Lynch M, Sayin U, Brownds J, Janumpali S, Sutula T. Long term consequences of early postnatal seizure on hippocampal learning and plasticity. Eur J Neurosci. 2000;12:2252-64.
25. Martin R, Kuzniecky R, Hetherington H. Cognitive effects of topiramate, gabapentin, and lamotrigine in healthy young adults. Neurology. 1999;52:321-7.
26. Meador KJ, Loring DW, Ray PG. Differential cognitive effects of carbamazepine and gabapentin. Epilepsia. 1999;40:1279-85.
27. Mohammed AH, Zhu SW, Darmopil S, Hjerling-Leffler J, Ernfors P, Winblad B, et al . Environmental enrichment and the brain. Prog Brain Res. 2002;138:109-33.
28. Mora F, Segovia G, Del AA. Aging, plasticity and environmental enrichment: structural changes and neurotransmitter dynamics in several areas of the brain. Brain Res Rev. 2007;55:78-88
29. Morris R. development of a water-maze procedure for studying spatial learning in a rat. J Neurosci Methods. 1984;11:47-60.
30. Nithianantharajah J, Hannan AJ. Enriched environments, experience-dependent plasticity and disorders of the nervous system. Nat Rev Neurosci. 2006;7:697-709.
31. Nowakowska E, Chodera A, Kus K. Behavioral and memory improving effects of mirtazapine in rats. Pol J Pharmacol. 1999;51:463-9.
32. Nowakowska E, Kus K, Chodera A, Rybakowski J. Behavioural effects of fluoxetine and tianeptine, two antidepressants with opposite action mechanisms, in rats. Arzneimittelforschung. 2000;50(1):5-10.
33. Nowakowska E, Kus K, Chodera A. Comparison of behavioural effects of venlafaxine and imipramine in rats. Arzneimittelforschung. 2003;53(4):237-42.
34. Nowakowska E, Kus K, Chodera A, Rybakowski J. Investigating potential anxiolytic, antidepressant and memory enhancing activity of deprenyl. J Physiol Pharmacol. 2001;52:863-73.
35. Nowakowska E, Kus K, Czubak A, Jedrzejewska A. Memory improving and antidepressant effects of topiramate in rats. Arzneimittelforschung. 2009;59(10):487-492.
36. Nowakowska E, Kus K, Florek E, Czubak A, Jodynis-Liebert J. The influence of tobacco smoke and nicotine on antidepressant and memory improving effects of venlafaxine. Hum Exp Toxicol. 2006;25(4):199-209.
37. Olson AK, Eadie BD, Ernst C, Christie BR. Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways. Hippocampus. 2006;16: 250-60.
38. Perrine K, Kiolbasa T. Cognitive deficits in epilepsy and contribution to psychopathology. Neurology. 1999;53(2):39-48
39. Porsolt RD, Anton G, Blavet N, Jalfre M. Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol. 1978;47:379-91.
40. Prica C, Hascoet M, Bourin M. Antidepressant-like effect of lamotrigine is reversed by veratrine: A possible role of sodium channels in bipolar depression. Behav Brain Res. 2008;191:49-54.
41. Rocha FL, hara C. Lamotrigine augmentation in unipolar depression. Int Clin Psychopharmacol. 2003;18:97-9.
42. Scoville WB, Milner B. Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry. 1957;20:11-21.
43. Shannon HE, Love PL. Effects of antiepileptic drugs on working memory as assessed by spatial alternation performance in rats. Epilepsy Behav. 2004;5:857-65.
44. Shannon HE, Love PL. Effects of antiepileptic drugs on attention as assessed by a 5-choice serial reaction time task in rats. Epilepsy Behav. 2005;7:620-8.
45. Shannon HE, Love PL. Effects of antiepileptic drugs on learning as assessed by a repeated acquisition of response sequences task in rats. Epilepsy Behav. 2007;10(1):16-25.
46. Sheline YI, Gado MH, Kraemer HC. Untreated depression and hippocampal volume loss. Am J Psychiatry. 2003;160:1516-8.
47. Sloviter RS. Status epilepticus-induced neuronal injury and network reorganization. Epilepsia. 2000;40(1):34-41.
48. Smith D, Baker G, Davies G, Dewey M, Chadwick DW. Outcomes of add-on treatment with lamotrigine in partial epilepsy. Epilepsia. 1993;34:312-22.
49. Southam E, Kirkby D, Higgins GA, Hagan RM. Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats. Eur J Pharmacol. 1998;358:19-24
50. Southam E, Pereira R, Stratton SC, Sargent R, Ford AJ, Butterfield LJ, et al. Effect of lamotrigine on the activities of monoamine oxidases A and B in vitro and on monoamine disposition in vivo. Eur J Pharmacol. 2005;591:237-45.
51. Squire LR. The neuropsychology of human memory. Annu Rev Neurosci. 1982;5:241-73.
52. Stefani A, Calabresi P, Pisami A, Mercuri NB, Siniscalchi A, Bernardi G. Falbamate inhibits dihydropyridine-sensitive calcium channels in central neurons. J Pharmacol Exp Ther. 1996;277:121-7.
53. Stefani A, Spadowi F, Bernardi G. Voltage-activated calcium channels: targets of antiepileptic drug therapy? Epilepsia. 1997;38:959-65.
54. Trullas R, Skolnick P. Functional antagonists at the NMDA receptor complex exhibit antidepressant actions. Eur J Pharmacol. 1990;185:1-10. (Pubitemid 20254891)
55. Uead S, Sakakibara S, Yoshimoto K. Effect of long-lasting serotonin depletion on enviromental enrichment-induced neurogenesis in adult rat hippocampus and spatial learning. Neuroscience. 2005;135:395-402.
56. Van Praag H, Kempermann G, Gage FH. Neural consequences of enviromental enrichment. Neuroscience. 2002;1:191-8.
57. Veena J, Strikumar BN, Raju TR, Shankaranarayana Rao BS. Exposure to enriched environment restores the survival and differentiation of new born cells in the hippocampus and ameliorates depressive symptoms in chronically stressed rats. Neurosci Lett. 2009;455:178-82.
58. Young D, Lawlor PA, Leone P, Dragunow M, During MJ. Enviromental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective. Nat Med. 1999;5:448-53.