Differential cognitive effects of carbamazepine and gabapentin

Epilepsia

Volumn 40, Issue 9, 1999, Pages 1279-1285

  Meador, K J ^a   Loring, D W ^a   Ray, P G ^a   Murro, A M ^a   King, D W ^a   Nichols, M E ^a   Deer, E M ^a   Goff, W T ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Carbamazepine; Cognition; EEG; Gabapentin; P3 potential

Indexed keywords

CARBAMAZEPINE; GABAPENTIN;

ADULT; ALERTNESS; ARTICLE; ATTENTION; CLINICAL TRIAL; COGNITION; COGNITIVE DEFECT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG RESPONSE; EPILEPSY; HUMAN; HUMAN EXPERIMENT; MEMORY; MOTOR PERFORMANCE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; VERTIGO;

ACETIC ACIDS; ADOLESCENT; ADULT; AMINES; ANTICONVULSANTS; ATTENTION; CARBAMAZEPINE; COGNITION; CROSS-OVER STUDIES; CYCLOHEXANECARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; ELECTROENCEPHALOGRAPHY; EVOKED POTENTIALS; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MALE; MEMORY; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS;

EID: 0032872770     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1528-1157.1999.tb00858.x     Document Type: Article

References (31)

1. Meador KJ. Cognitive effects of epilepsy and of antiepileptic medications. In: Wyllie E, ed. The treatment of epilepsy: principles and practice. 2nd ed. Baltimore: Williams & Wilkins, 1996:1121-30.
2. Meador KJ. The cognitive effects of the new AEDs. Neurologist 1998;4.S35-9.
3. Dimond KR, Pande AC, Lamoreaux L, Pierce MW. Effect of gabapentin (Neurontin®) on mood and well-being inpatients with epilepsy. Prog Neuro-psychopharmacol Biol Psychiatry 1996;20:407-17.
4. Dodrill CB, Arnett JL, Hayes AG, et al. Evaluation of quality of life during a double-blind multicenter study of gabapentin (GBP; Neurontin) monotherapy in patients with medically refractory partial seizures. Epilepsia 1995;36(suppl 4):88.
5. Smith D, Baker G, Davies G, Dewey M, Chadwick DW. Outcomes of add-on treatment with lamotrigine in partial epilepsy. Epilepsia 1993;34:312-22.
6. Meador KJ, Baker GA. Behavioral and cognitive effects of lamotrigine. J Child Neurol 1997;12(suppl 1):S44-7.
7. Smith DB, Mattson RH, Cramer JA, et al. Results of a nationwide Veterans Administration Cooperative Study comparing the efficacy and toxicity of carbamazepine, phenobarbital, phenytoin, and primidone. Epilepsia 1987;28(suppl 3):S50-8.
8. Anhut H, Ashman P, Feuerstein TJ, et al. Gabapentin (Neurontin) as add-on therapy in patients with partial seizures: a double-blind, placebo-controlled study. Epilepsia 1994;35:795-801.
9. Saletu B, Grunberger J, Linzmayer L. Evaluation of encephalotropic and psychotropic properties of gabapentin in man by pharmaco-EEG and psychometry. Int J Clin Pharmacol Ther Toxicol 1986;24:362-73.
10. Leach JP, Girvan J, Paul A, Brodie MJ. Gabapentin and cognition: a double-blind, dose-ranging, placebo-controlled study in refractory epilepsy. J Neurol Neurosurg Psychiatry 1997;62:372-6.
11. Wolf SM, Shinnar S, Kang H, Gil KB, Moshe SL. Gabapentin toxicity in children manifesting as behavioral changes. Epilepsia 1995;36:1203-5.
12. Childers MK, Holland D. Psychomotor agitation following gabapentin use in brain injury. Brain Injury 1997;11:537-40.
13. Meador KJ, Loring DW, Allen ME, et al. Comparative cognitive effects of carbamazepine and phenytoin in healthy adults. Neurology 1991;41:1537-40.
14. Meador KJ, Loring DW, Abney OL, et al. Effects of carbamazepine and phenytoin on EEG and memory in healthy adults. Epilepsia 1993;34:153-7.
15. Meador KJ, Loring DW, Moore EE, et al. Comparative cognitive effects of phenobarbital, phenytoin and valproate in healthy subjects. Neurology 1995;45:1494-9.
16. Salinsky MC, Oken BS, Binder LM. Assessment of drowsiness in epilepsy patients receiving chronic antiepileptic drug therapy. Epilepsia 1996;37:181-7.
17. Ray PG, Meador KJ, Loring DW, Zamrini EY, Yang XH, Buccafusco JJ. Central anticholinergic hypersensitivity in aging. J Geriatr Psychiatr Neurol 1992;5:72-7.
18. Dodrill CB, Arnett JL, Sommerville KW, Sussman NM. Effects of differing dosages of vigabatrin (Sabril) on cognitive abilities and quality of life in epilepsy. Epilepsy 1995;36:164-73.
19. Lachman R, Lachman JL, Butterfield EC. Cognitive psychology and information processing: an introduction. Hillsdale, NJ: Lawrence Erlbaum, 1979.
20. Lezak MD. Neuropsychological assessment. 3rd ed. New York: Oxford University Press, 1995.
21. Buschke H, Fuld PA. Evaluating storage, retention, and retrieval in disordered memory and learning. Neurology 1974;24:1019-25.
22. Smith A. Symbol digit modalities test: manual. Los Angeles: Western Psychological Services, 1973.
23. Golden CJ. Stroop color and word test: a manual for clinical and experimental uses. Chicago: Stocking, 1978.
24. Lorr M, McNair DM, Droppleman LF. Manual: profile of mood states. San Diego, CA: Educational and Industrial Testing Service, 1971.
25. Lipman RS, Covi L, Shapiro AK. The Hopkins Symptom Checklist (HSCL): factors derived from the HSCL-90. J Affect Disord 1979;1:9-24.
26. Kane RL, Kay GG. Computer applications in neuropsychological assessment. In: Goldstein G, Incagnoli T, eds. Contemporary approaches to neuropsychological assessment. New York: Plenum, 1997:XX-XX.
27. Hillyard SA, Picton TW. Electrophysiology of cognition. In: Mountcastle VB, Plum F, Geiger SR, eds. Handbook of physiology. Section 1: the nervous system. Bethesda, MD: American Physiological Society, 1987:519-84.
28. Mitler M, Gujavarty S, Browman C. Maintenance of wakefulness test: a polysomnographic technique for evaluating treatment efficacy in patients with excessive somnolence. Electroencephalogr Clin Neurophysiol 1982;53:658-61.
29. Meador KJ, Kamin M, Topiramate TPS-TR Study Team. Assessing cognitive effects of a new AED with the bias of practice effects. Epilepsia 1997;38(suppl 3):60.
30. Dodrill CB, Wilensky AJ. Neuropsychological abilities before and after 5 years of stable antiepileptic drug therapy. Epilepsia 1992; 33:327-34.
31. Martin R, Kuzniecky R, Ho S, et al. Cognitive effects of topiramate, gabapentin, and lamotrigine in healthy young adults. Neurology 1999;52:321-6.