MGMT 2535G>T polymorphism is associated with prognosis for patients with metastatic colorectal cancer treated with oxaliplatin-based chemotherapy

Journal of Cancer Research and Clinical Oncology

Volumn 136, Issue 8, 2010, Pages 1135-1142

  Park, Jee Hyun ^a   Kim, Nung Soo ^a   Park, Jae Yong ^a   Chae, Yee Soo ^a   Kim, Jong Gwang ^a   Sohn, Sang Kyun ^a   Moon, Joon Ho ^a   Kang, Byung Woog ^a   Ryoo, Hun Mo ^b   Bae, Sung Hwa ^b   Choi, Gyu Seog ^a   Jun, Soo Han ^a  

^a Kyungpook National University Hospital   (South Korea)

^b Catholic University of Daegu   (South Korea)

Author keywords

Biomarker; Colorectal cancer; MGMT; Oxaliplatin; Polymorphism

Indexed keywords

CAPECITABINE; DNA METHYLTRANSFERASE 3B; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 4; FLUOROURACIL; FOLINIC ACID; GENOMIC DNA; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; NUCLEAR PROTEIN; OXALIPLATIN; PROTEIN MSH2; PROTEIN NBN; PROTEIN POLE; PROTEIN POLR2A; PROTEIN POLR2B; PROTEIN POLR2C; PROTEIN RFC1; PROTEIN RFC4; PROTEIN VARS2; PROTEIN XAB2; UNCLASSIFIED DRUG; XERODERMA PIGMENTOSUM GROUP C PROTEIN; XRCC1 PROTEIN; ANTINEOPLASTIC AGENT; DEOXYCYTIDINE; DNA METHYLTRANSFERASE; DRUG DERIVATIVE; MGMT PROTEIN, HUMAN; PLATINUM COMPLEX; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; TUMOR SUPPRESSOR PROTEIN; XELOX;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER MORTALITY; CANCER SURVIVAL; COLORECTAL CANCER; COLORECTAL SURGERY; CONTROLLED STUDY; DNA REPAIR; DRUG RESPONSE; FEMALE; FOLLOW UP; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; MUTATIONAL ANALYSIS; OVERALL SURVIVAL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; PROGRESSION FREE SURVIVAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; AMINO ACID SUBSTITUTION; CHROMOSOME MAP; COLON TUMOR; COLORECTAL TUMOR; GENETIC POLYMORPHISM; GENETICS; METASTASIS; MIDDLE AGED; PATHOLOGY; RECTUM TUMOR;

AMINO ACID SUBSTITUTION; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHROMOSOME MAPPING; COLONIC NEOPLASMS; COLORECTAL NEOPLASMS; DEOXYCYTIDINE; DNA MODIFICATION METHYLASES; DNA REPAIR; DNA REPAIR ENZYMES; FEMALE; FLUOROURACIL; GENOTYPE; HUMANS; MALE; MIDDLE AGED; NEOPLASM METASTASIS; ORGANOPLATINUM COMPOUNDS; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; RECTAL NEOPLASMS; TUMOR SUPPRESSOR PROTEINS;

EID: 77954585607     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-010-0760-8     Document Type: Article

References (30)

1. Arkenau HT, Arnold D, Cassidy J et al. (2008) Efficacy of oxaliplatin plus capecitabine or infusional fluorouracil/leucovorin in patients with metastatic colorectal cancer: a pooled analysis of randomized trials. J Clin Oncol 26:5910-5917
2. Carethers JM, Chauhan DP, Fink D et al. (1999) Mismatch repair proficiency and in vitro response to 5-fluorouracil. Gastroenterology 117:123-131
3. Chae MH, Jang JS, Kang HG et al. (2006) O6-alkylguanine-DNA alkyltransferase gene polymorphisms and the risk of primary lung cancer. Mol Carcinog 45:239-249
4. Diaz-Rubio E, Tabernero J, Gomez-Espana A et al. (2007) Phase III study of capecitabine plus oxaliplatin compared with continuousinfusion fluorouracil plus oxaliplatin as first-line therapy in metastatic colorectal cancer: final report of the Spanish Cooperative Group for the Treatment of Digestive Tumors Trial. J Clin Oncol 25:4224-4230
5. Egyhazi S, Margison GP, Hansson J, Ringborg U (1997) Immunohistochemical examination of the expression of O6-methylguanine- DNA methyltransferase in human melanoma metastases. Eur J Cancer 33:129-134
6. Giacchetti S, Perpoint B, Zidani R et al. (2000) Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer. J Clin Oncol 18:136-147
7. Grothey A, Sargent D, Goldberg RM, Schmoll HJ (2004) Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment. J Clin Oncol 22:1209-1214
8. Hazra TK, Roy R, Biswas T et al. (1997) Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase. Biochemistry 36: 5769-5776
9. Hu Z, Wang H, Shao M et al. (2007) Genetic variants in MGMT and risk of lung cancer in Southeastern Chinese: a haplotype-based analysis. Hum Mutat 28:431-440
10. Hutter P, Couturier A, Rey-Berthod C (2000) Two common forms of the human MLH1 gene may be associated with functional differences. J Med Genet 37:776-781
11. Improta G, Sgambato A, Bianchino G et al. (2008) Polymorphisms of the DNA repair genes XRCC1 and XRCC3 and risk of lung and colorectal cancer: a case-control study in a Southern Italian population. Anticancer Res 28:2941-2946
12. Jin MJ, Chen K, Song L et al. (2005) The association of the DNA repair gene XRCC3 Thr241Met polymorphism with susceptibility to colorectal cancer in a Chinese population. Cancer Genet Cytogenet 163:38-43
13. Jin MJ, Chen K, Zhang Y et al. (2007) Correlations of single nucleotide polymorphisms of DNA repair gene XRCC1 to risk of colorectal cancer. Ai Zheng 26:274-279
14. Kim JG, Sohn SK, Chae YS et al. (2007) Vascular endothelial growth factor gene polymorphisms associated with prognosis for patients with gastric cancer. Ann Oncol 18:1030-1036
15. Koessler T, Azzato EM, Perkins B et al. (2009) Common germline variation in mismatch repair genes and survival after a diagnosis of colorectal cancer. Int J Cancer 124:1887-1891
16. Longley DB, Boyer J, Allen WL et al. (2002) The role of thymidylate synthase induction in modulating p53-regulated gene expression in response to 5-fluorouracil and antifolates. Cancer Res 62:2644-2649
17. Ma S, Egyhazi S, Ueno T et al. (2003) O6-methylguanine- DNAmethyltransferase expression and gene polymorphisms in relation to chemotherapeutic response in metastatic melanoma. Br J Cancer 89:1517-1523
18. Madhusudan S, Middleton MR (2005) The emerging role of DNA repair proteins as predictive, prognostic and therapeutic targets in cancer. Cancer Treat Rev 31:603-617
19. Margison GP, Santibanez-Koref MF (2002) O6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy. Bioessays 24:255-266
20. Margison GP, Povey AC, Kaina B, Santibanez Koref MF (2003) Variability and regulation of O6-alkylguanine-DNA alkyltransferase. Carcinogenesis 24:625-635
21. Meyers M, Wagner MW, Hwang HS, Kinsella TJ, Boothman DA (2001) Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses. Cancer Res 61:5193-5201
22. Moon JH, Kim JG, Sohn SK et al. (2007) Outpatient-basis chemotherapy of oxaliplatin, 5-fluorouracil, and leucovorin as first-line treatment for patients with metastatic or recurrent colorectal cancer. J Korean Med Sci 22:400-404
23. Moreno V, Gemignani F, Landi S et al. (2006) Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer. Clin Cancer Res 12:2101-2108
24. Ogino S, Hazra A, Tranah GJ et al. (2007) MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer. Carcinogenesis 28:1985-1990 (Pubitemid 47514483)
25. Park DJ, Stoehlmacher J, Zhang W et al. (2001) A Xeroderma pigmentosum group D gene polymorphism predicts clinical outcome to platinum-based chemotherapy in patients with advanced colorectal cancer. Cancer Res 61:8654-8658
26. Park DJ, Zhang W, Stoehlmacher J et al. (2003) ERCC1 gene polymorphism as a predictor for clinical outcome in advanced colorectal cancer patients treated with platinum-based chemotherapy. Clin Adv Hematol Oncol 1:162-166
27. Pegg AE (1990) Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res 50:6119-6129
28. Stoehlmacher J, Ghaderi V, Iobal S et al. (2001) A polymorphism of the XRCC1 gene predicts for response to platinum based treatment in advanced colorectal cancer. Anticancer Res 21:3075-3079
29. Trojan J, Zeuzem S, Randolph A et al. (2002) Functional analysis of hMLH1 variants and HNPCC-related mutations using a human expression system. Gastroenterology 122:211-219
30. Yuan HY, Chiou JJ, Tseng WH et al. (2006) FASTSNP: an always upto- date and extendable service for SNP function analysis and prioritization. Nucleic Acids Res 34:W635-W641