Substance P (NK1) receptor immunoreactivity on endothelial cells of the rat tracheal mucosa

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 270, Issue 3 14-3, 1996, Pages

  Bowden, Jeffrey J ^b   Baluk, Peter ^b   Lefevre, Peter M ^b   Vigna, Steven R ^b   McDonald, Donald M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

endosomes; immunohistochemistry; neurogenic inflammation; plasma leakage; postcapillary venules; receptor internalization; tachykinins; vagal stimulation; vascular permeability

Indexed keywords

NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; NOLPITANTIUM; SUBSTANCE P; SUBSTANCE P RECEPTOR; THROMBOCYTE ACTIVATING FACTOR; BIOLOGICAL MARKER;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; ENDOSOME; ENDOTHELIUM CELL; EXTRAVASATION; IMMUNOREACTIVITY; INFLAMMATION; INTERNALIZATION; MALE; NERVE LESION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; TRACHEA MUCOSA; VAGUS NERVE STIMULATION; ANIMAL; ARTERIOLE; CYTOLOGY; ELECTROSTIMULATION; ENDOCYTOSIS; FISCHER 344 RAT; IMMUNOHISTOCHEMISTRY; INNERVATION; MUCOSA; PHYSIOLOGY; TRACHEA; ULTRASTRUCTURE; VAGUS NERVE; VASCULAR ENDOTHELIUM; VASCULARIZATION; VENULE;

ANIMALS; ARTERIOLES; BIOLOGICAL MARKERS; ELECTRIC STIMULATION; ENDOCYTOSIS; ENDOSOMES; ENDOTHELIUM, VASCULAR; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MUCOUS MEMBRANE; RATS; RATS, INBRED F344; RECEPTORS, NEUROKININ-1; SUBSTANCE P; TRACHEA; VAGUS NERVE; VENULES;

EID: 0030094526     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1996.270.3.l404     Document Type: Article

References (47)

1. Abelli, L., F. Nappi, C. A. Maggi, P. Rovero, M. Astolfl, D. Regoli, G. Drapeau, and A. Giachetti. NK-1 receptors and vascular permeability in rat airways. Ann. NY Acad. Sci. 632: 358-359, 1991.
2. Baluk, P., C. Bertrand, P. Geppetti, D. M. McDonald, and J. A. Nadel. NK-1 receptors mediate leukocyte adhesion in neurogenic inflammation in the rat trachea. Am. J. Physiol 268 (Lung Cell. Mol. Physiol. 12): L263-L269, 1995.
3. Baluk, P., J. J. Bowden, P. L. Lefevre, and D. M. McDonald. Increased expression of substance P (NK1) receptors on airway blood vessels of rats with Mycoplasma pulmonis infection. Am. J. Respir. Crit. Care Med. 151: A719, 1995.
4. Baluk, P., J. A. Nadel, and D. M. McDonald. Substance P-immunoreactive sensory axons in the rat respiratory tract: a quantitative study of their distribution and role in neurogenic inflammation. J. Comp. Neurol. 319: 586-598, 1992.
5. Baraniuk, J. N., J. D. Lundgren, M. Okayama, J. Goff, J. Mullol, M. Merida, J. H. Shelhamer, and M. A. Kaliner. Substance-P and neurokinin-A in human nasal mucosa. Am. J. Respir. Cell Mol. Biol. 4: 228-236, 1991.
6. Bertrand, C., P. Geppetti, J. Baker, I. Yamawaki, and J. A. Nadel. Role of neurogenic inflammation in antigen-induced vascular extravasation in guinea pig trachea. J. Immunol. 150: 1479-1485, 1993.
7. Black, J. L., L. M. Diment, L. A. Alouan, P. R. A. Johnson, C. L. Armour, T. Badgeryparker, and E. Burcher. Taehykinin receptors in rabbit airways: characterization by functional, autoradiographic and binding studies. Br. J. Pharmacol. 107: 429-436, 1992
8. Borson, D. B. Roles of neutral endopeptidase in airways. Am. J. Physiol. 260 (Lung Cell. Mol. Physiol. 4): L212-L225, 1991.
9. 1 receptors at sites of inflammation. Proc. Natl. Acad. Sci. USA 91: 8964-8968, 1994.
10. Burcher, E., C. J. Mussap, and J. A. Stephenson. Autoradiographic localization of receptors in peripheral tissues. In: The Tachykinin Receptors, edited by S. H. Buck. Totowa, NJ: Humana, 1994, p. 125-163.
11. Carstairs, J. R., and P. J. Barnes. Autoradiographic mapping of substance P receptors in lung. Eur. J. Pharmacol. 127: 295-296, 1986.
12. Choi, H. S., M. Lesser, C. Cardozo, and M. Orlowski. Immunohistochemical localization of endopeptidase 24.15 in rat trachea, lung tissue, and alveolar macrophages. Am. J. Respir. Cell Mol. Biol. 3: 619-624, 1990.
13. Delay-Goyet, P., A. Franco-Cereceda, S. F. Gonsalves, C. A. Clingan, J. D. Lowe, and J. M. Lundberg. CP-96,345 antagonism of NK1 receptors and smoke-induced protein extravasation in relation to its cardiovascular effects Eur. J. Pharmacol. 222: 213-218, 1992
14. 1 receptor antagonist. Eur. J. Pharmacol. 250: 403-413, 1993.
15. Fischer, A., W. Kummer, J. Y. Couraud, D. Adler, D. Branscheid, and C. Heym. Immunohistochemical localization of receptors for vasoactive intestinal peptide and substance-P in human trachea. Lab. Invest. 67: 387-393, 1992.
16. Fong, T. M., S. A. Anderson, H. Yu, R.-R. C. Huang, and C. D. Strader. Differential activation of intracellular effector by two isoforms of human neurokimn-1 receptor. Mol. Pharmacol. 41: 24-30, 1992.
17. Furchgott, R. F. Role of endothelium in responses of vascular smooth muscle. Circ. Res 53: 557-573, 1983.
18. Hoover, D. B., and J. C. Hancock. Autoradiographic localization of substance P binding sites in guinea-pig airways. J. Auton. Nerv. Syst. 19: 171-174, 1987.
19. Ichikawa, S., S. P. Sreedharan, R. L. Owen, and E. J. Goetzl. Immunochemical localization of type IVIP receptor and NK-1-type substance P receptor in rat lung. Am. J. Physiol. 268 (Lung Cell Mol. Physiol. 12): L584-L588, 1995.
20. Jancso, N., A. Jancsó-Gábor, and J. Szolcsányi. Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin. Br. J. Pharmacol. Chemotherap. 31: 138-151, 1967.
21. Joos, G. F., J. C. Kips, and R. A. Pauwels. In vivo characterization of the tachykinin receptors involved in the direct and indirect bronchoconstrictor effect of tachykimns in two inbred rat strains. Am. J. Respir. Crit. Care Med. 149: 1160-1166, 1994.
22. Kage, R., S. E. Leeman, and N. D. Boyd. Biochemical characterization of two different forms of the substance P receptor in rat submaxillary gland. J. Neurochem. 60: 347-351, 1993.
23. Kummer, W., A. Fischer, J. Y. Couraud, and C. Heym. Immunohistochemistry of peptides (substance-P and VIP) and peptide receptors in the trachea. J. Auton. Nerv. Syst. 33: 121-123, 1991.
24. Kummer, W., A. Fischer, U. Preissler, J. Y. Couraud, and C. Heym. Immunohistochemistry of the guinea-pig trachea using an anti-idiotypic antibody recognizing substance-P receptors. Histochemistry 93: 541-546, 1990.
25. Larsen, P. J., J. D. Mikkelsen, S. Mau, and T. Saermark, Binding and internalization of a iodinated substance P analog by cultured anterior pituitary cells. Mol. Cell. Endocrinol. 65: 91-101, 1989.
26. 1 receptor antagonist. Br. J. Pharmacol. 106: 261-262, 1992.
27. Lundberg, J. M., and A. Saria. Capsaicin-induced desensitization of airway mucosa to cigarette smoke, mechanical and chemical irritants. Nature Lond. 302: 251-253, 1983.
28. Maggi, C. A., R. Patacchini, P. Rovero, and A. Giachetti. Tachykinin receptors and tachykinin receptor antagonists. J. Auton. Pharmacol. 13: 23-93, 1993.
29. Mantyh, P. W., C. J. Allen, J. R. Ghilardi, S. D. Rogers, C. R. Mantyh, H. Liu, A. I. Basbaum, S. R. Vigna, and J. E. Maggio. Rapid endocytosis of a G protein-coupled receptor: substance P-evoked internalization of its receptor in the rat striatum in vivo. Proc. Natl. Acad. Sci. USA 92: 2622-2626, 1995.
30. McDonald, D. M. Neurogenic inflammation m the rat trachea. I. Changes in venules, leukocytes, and epithelial cells. J. Neurocytol. 17: 583-603, 1988.
31. McDonald, D. M. Respiratory tract infections increase susceptibility to neurogenic inflammation in the rat trachea. Am. Rev. Respir. Dis. 137: 1432-1440, 1988.
32. McDonald, D. M. The ultrastructure and permeability of tracheobronchial blood vessels in health and disease. Eur. Respir. J. 3, Suppl. 12: 572S-585S, 1990.
33. McDonald, D. M. The concept of neurogenic inflammation in the respiratory tract. In: Neuropeptides in Respiratory Medicine, edited by M. Kaliner, P Barnes, G. Kunkel, and J. Baraniuk. New York: Marcel Dekker, 1994, p. 321-349.
34. McDonald, D. M. Endothelial gaps and permeability of venules in rat tracheae exposed to inflammatory stimuli. Am. J. Physiol. 266 (Lung Cell. Mol. Physiol. 10): L61-L83, 1994.
35. McDonald, D. M., R. A. Mitchell, G. Gabella, and A. Haskell. Neurogenic inflammation in the rat trachea. II. Identity and distribution of nerves mediating the increase in vascular permeability. J. Neurocytol. 17: 605-628, 1988.
36. McDonald, D. M., T. R. Schoeb, and J. R. Lindsey. Mycoplasma pulmonis infections cause long-lasting potentiation of neurogenic inflammation in the respiratory tract of the rat. J. Clin. Invest. 87: 787-799, 1991.
37. 3H]FK888. Mol. Pharmacol. 44: 539-544, 1993.
38. Pernow, B. Substance P. Pharmacol. Rev. 35: 85-141, 1983.
39. Piedimonte, G., J. I. Hoffman, W. K. Husseini, K. M. Snider, M. C. Desai, and J. A. Nadel. NK1 receptors mediate neurogenic inflammatory increase in blood flow in rat airways. J. Appl. Physiol. 74: 2462-2468, 1993.
40. Sakamoto, T., P. J. Barnes, and K. F. Chung. Effect of CP-96,345, a non-peptide NK1 receptor antagonist, against substance P-induced, bradykinin-induced and allergen-induced airway microvascular leakage and bronchoconstriction in the guinea pig. Eur. J. Pharmacol. 231: 31-38, 1993.
41. Sertl, K., C. J. Wiedermann, M. L. Kowalski, S. Hurtado, J. Plutchok, I. Linnoila, C. B. Pert, and M. A. Kaliner. Substance P: the relationship between receptor distribution in rat lung and the capacity of substance P to stimulate vascular permeability Am. Rev. Respir. Dis. 138: 151-159, 1988.
42. Sjödin, L. Cholecystokinin-induced inhibition of endocytosis of receptor-bound substance P in pancreatic acinar cells. J. Recept. Res. 12: 323-350, 1992.
43. 125I-BoltonHunter substance P binding to dog carotid artery. Eur. J. Pharmacol. 124: 377-378, 1986.
44. Sulakvelidze, L, and D. M. McDonald. Anti-edema action of formoterol in rat trachea does not depend on capsaicin-sensitive sensory nerves. Am. J. Respir. Crit. Care Med. 149: 232-328, 1994.
45. Vigna, S. R., J. J. Bowden, D. M. McDonald, J. Fisher, A, Okamoto, D. C. McVey, P. G. Payan, and N. W. Bunnett. Characterization of antibodies to the rat substance P (NK-1) receptor and to a chimeric substance P receptor expressed in mammalian cells. J. Neurosci. 14: 834-845, 1994.
46. Webber, S. E. Receptors mediating the effects of substance P and neurokinin A on mucus secretion and smooth muscle tone of the ferret trachea: potentiation by an enkephalinase inhibitor. Br. J. Pharmacol. 98: 1197-1206, 1989.
47. Wong, L. B., I. F. Miller, and D. B. Yeates. Pathways of substance P stimulation of canine tracheal ciliary beat frequency. J. Appl. Physiol. 70: 267-273, 1991.