Immunologic characterization of posthepatitis cirrhosis caused by HBV and HCV infection

Journal of Biomedicine and Biotechnology

Volumn 2010, Issue , 2010, Pages

  Niu, Jun Qi ^a   Li, Wan Yu ^a   Jiang, Yan Fang ^a   Jin, Qing Long ^a   Zhang, Hong ^a   Feng, Xiang Wei ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; NUCLEOSIDE ANALOG; NUCLEOTIDE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; CD4 ANTIGEN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE;

ADAPTIVE IMMUNITY; ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ANTIVIRAL THERAPY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CD25+ T LYMPHOCYTE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CYTOKINE RELEASE; FEMALE; FLOW CYTOMETRY; HEPATITIS B; HEPATITIS C; HUMAN; IMMUNE STATUS; INNATE IMMUNITY; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER CELL; PHENOTYPE; PROSPECTIVE STUDY; PROTHROMBIN TIME; REGULATORY T LYMPHOCYTE; CD4 CD8 RATIO; IMMUNOLOGY; LYMPHOCYTE; METABOLISM; MIDDLE AGED;

HEPATITIS B VIRUS; HEPATITIS C VIRUS;

ADULT; AGED; ANTIGENS, CD4; CD4-CD8 RATIO; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HEPATITIS B; HEPATITIS C; HUMANS; INTERFERON-GAMMA; INTERLEUKINS; LIVER CIRRHOSIS; LYMPHOCYTES; MALE; MIDDLE AGED;

EID: 77954551689     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2010/138237     Document Type: Article

References (29)

1. National Digestive Diseases Information Clearing House, Cirrhosis. January 2008
2. Bertoletti A., Gehring A. J., The immune response during hepatitis B virus infection Journal of General Virology 2006 87 6 1439 1449
3. Chen W. N., Feng H., Zhang J., Li X., HBX-Mediated migration of HBV-replicating HepG2 cells: insights on development of hepatocellular carcinoma Journal of Biomedicine and Biotechnology 2009 2009 6
4. Manigold T., Racanelli V., T-cell regulation by CD4 regulatory T cells during hepatitis B and C virus infections: facts and controversies Lancet Infectious Diseases 2007 7 12 804 813
5. Kondo Y., Asabe S., Kobayashi K., Shiina M., Niitsuma H., Ueno Y., Kobayashi T., Shimosegawa T., Recovery of functional cytotoxic T lymphocytes during lamivudine therapy by acquiring multi-specificity Journal of Medical Virology 2004 74 3 425 433
6. Liu W., Putnam A. L., Xu-Yu Z., Szot G. L., Lee M. R., Zhu S., Gottlieb P. A., Kapranov P., Gingeras T. R., De St. Groth B. F., Clayberger C., Soper D. M., Ziegler S. F., Bluestone J. A., CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells Journal of Experimental Medicine 2006 203 7 1701 1711
7. Zarife M. A. S., Reis E. A. G., Carmo T. M. A., Lopes G. B., Brando E. C.M., Silva H. R., Santana N., Martins-Filho O.A., Reis M. G., Increased frequency of CD56 Bright NK-cells, CD3 - CD16 + CD56 - NK-cells and activated CD4 + T-cells or B-cells in parallel with CD4 + CDC25 High T-cells control potentially viremia in blood donors with HCV Journal of Medical Virology 2009 81 1 49 59
8. Ahmad S. F., Pandey A., Kour K., Bani S., Downregulation of pro-inflammatory cytokines by lupeol measured using cytometric bead array immunoassay Phytotherapy Research 2010 24 1 9 13
9. Tseng C.-T. K., Klimpel G. R., Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions Journal of Experimental Medicine 2002 195 1 43 49
10. Xiao Y., Hendriks J., Langerak P., Jacobs H., Borst J., CD27 is acquired by primed B cells at the centroblast stage and promotes germinal center formation Journal of Immunology 2004 172 12 7432 7441
11. Liu Z.-X., Govindadarajan S., Okamoto S., Dennert G., NK cells cause liver injury and facilitate the induction of T cell- mediated immunity to a viral liver infection Journal of Immunology 2000 164 12 6480 6486
12. Koziel M. J., Cellular immune responses against hepatitis C virus Clinical Infectious Diseases 2005 41 1 S25 S31
13. You J., Sriplung H., Geater A., Chongsuvivatwong V., Zhuang L., Li Y.-L., Lei H., Liu J., Chen H.-Y., Tang B.-Z., Huang J.-H., Impact of viral replication inhibition by entecavir on peripheral T lymphocyte subpopulations in chronic hepatitis B patients BMC Infectious Diseases 2008 8, article 123
14. Tang T. J., Kwekkeboom J., Mancham S., Binda R. S., De Man R. A., Schalm S. W., Kusters J. G., Janssen H. L. A., Intrahepatic CD8+ T-lymphocyte response is important for therapy-induced viral clearance in chronic hepatitis B infection Journal of Hepatology 2005 43 1 45 52
15. Zhang H., Wu L.-Y., Zhang S., Anti-hepatitis B virus X protein in sera is one of the markers of development of liver cirrhosis and liver cancer mediated by HBV Journal of Biomedicine and Biotechnology 2009 2009 6
16. Stoop J. N., van der Molen R. G., Baan C. C., Van Der Laan L. J. W., Kuipers E. J., Kusters J. G., Janssen H. L. A., Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection Hepatology 2005 41 4 771 778
17. Sobue S., Nomura T., Ishikawa T., Ito S., Saso K., Ohara H., Joh T., Itoh M., Kakumu S., Th1/Th2 cytokine profiles and their relationship to clinical features in patients with chronic hepatitis C virus infection Journal of Gastroenterology 2001 36 8 544 551
18. Bertoletti A., D'Elios M. M., Boni C., De Carli M., Zignego A. L., Durazzo M., Missale G., Penna A., Fiaccadori F., Del Prete G., Ferrari C., Different cytokine profiles of intrahepatic T cells in chronic hepatitis B and hepatitis C virus infections Gastroenterology 1997 112 1 193 199
19. Lee Y., Park U.-S., Choi I., Yoon S. K., Park Y. M., Lee Y. I., Human interleukin 6 gene is activated by hepatitis B virus-X protein in human hepatoma cells Clinical Cancer Research 1998 4 7 1711 1717
20. Antonelli A., Ferri C., Ferrari S. M., Ghiri E., Marchi S., Colaci M., Bruschi F., Fallahi P., High interleukin-6 and tumor necrosis factor-alpha serum levels in hepatitis C infection associated or not with mixed cryoglobulinemia Clinical Rheumatology 2009 28 10 1179 1185
21. Hung C.-H., Lee C.-M., Chen C.-H., Hu T.-H., Jiang S.-R., Wang J.-H., Lu S.-N., Wang P.-W., Association of inflammatory and anti-inflammatory cytokines with insulin resistance in chronic hepatitis C Liver International 2009 29 7 1086 1093
22. Wan L., Kung Y.-J., Lin Y.-J., Liao C.-C., Sheu J. J. C., Tsai Y., Lai H.-C., Peng C.-Y., Tsai F.-J., Th1 and Th2 cytokines are elevated in HCV-infected SVR(-) patients treated with interferon- Biochemical and Biophysical Research Communications 2009 379 4 855 860
23. Feldmann G., Nischalke H. D., Nattermann J., Banas B., Berg T., Teschendorf C., Schmiegel W., Dhrsen U., Halangk J., Iwan A., Sauerbruch T., Caselmann W. H., Spengler U., Induction of interleukin-6 by hepatitis C virus core protein in hepatitis C-associated mixed cryoglobulinemia and B-cell non-Hodgkin's lymphoma Clinical Cancer Research 2006 12 15 4491 4498
24. Shin E.-C., Protzer U., Untergasser A., Feinstone S. M., Rice C. M., Hasselschwert D., Rehermann B., Liver-directed gamma interferon gene delivery in chronic hepatitis C Journal of Virology 2005 79 21 13412 13420
25. Penna A., Del Prete G., Cavalli A., Bertoletti A., D'Elios M. M., Sorrentino R., D'Amato M., Boni C., Pilli M., Fiaccadori F., Ferrari C., Predominant T-helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B Hepatology 1997 25 4 1022 1027
26. Byrnes A. A., Li D.-Y., Park K., Thompson D., Mocilnikar C., Mohan P., Molleston J. P., Narkewicz M., Zhou H., Wolf S. F., Schwarz K. B., Karp C. L., Modulation of the IL-12/IFN- axis by IFN- therapy for hepatitis C Journal of Leukocyte Biology 2007 81 3 825 834
27. Jo J., Thimme R., Immune responses to hepatitis B and C Hepatology International 2010 4 supplement 1 S80 S85
28. Anthony D. D., Post A. B., Valdez H., Peterson D. L., Murphy M., Heeger P. S., ELISPOT analysis of hepatitis C virus protein-specific IFN- -producing peripheral blood lymphocytes in infected humans with and without cirrhosis Clinical Immunology 2001 99 2 232 240
29. Wursthorn K., Lutgehetmann M., Dandri M., Volz T., Buggisch P., Zollner B., Longerich T., Schirmacher P., Metzler F., Zankel M., Fischer C., Currie G., Brosgart C., Petersen J., Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B Hepatology 2006 44 3 675 684