The stability and sterility of epinephrine prefilled syringe

Asian Pacific Journal of Allergy and Immunology

Volumn 28, Issue 1, 2010, Pages 53-57

  Kerddonfak, Saowanee ^a   Manuyakorn, Wiparat ^a   Kamchaisatian, Wasu ^a   Sasisakulporn, Cherapat ^a   Teawsomboonkit, Wanlapa ^a   Benjaponpitak, Suwat ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN;

ANAPHYLAXIS; ARTICLE; CONCENTRATION (PARAMETERS); DRUG POTENCY; DRUG STABILITY; DRUG STERILITY; EVALUATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PH; SYRINGE;

ANAPHYLAXIS; CAPSULES; COLONY COUNT, MICROBIAL; DRUG STABILITY; DRUG STORAGE; EPINEPHRINE; FEASIBILITY STUDIES; HOT TEMPERATURE; HUMANS; PHARMACEUTICAL SOLUTIONS; PRACTICE GUIDELINES AS TOPIC; SELF ADMINISTRATION; STERILIZATION; SYRINGES; TIME FACTORS;

EID: 77954544917     PISSN: 0125877X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Sheikh A, Shehata YA, Brown SGA, Simons FER. Adrenaline (epinephrine) for the treatment of anaphylaxis with and without shock. Cochrane Database of Systematic Reviews 2008, Issue 4. Art. No.:CD006312. DOI:10.1002/14651858.CD006312.pub2.
2. Grant TA, Carroll RG, Church WH, et al. Environmental temperature variations cause degradations in epinephrine concentration and biological activity. Am J Emerg Med 1994; 12: 319-22.
3. Simons FE, Gu X, Simons KJ. Outdated EpiPen and EpiPen Jr autoinjectors: past their prime? J Allergy Clin Immunol 2000; 105: 1025-30.
4. Westfall TC, Westfall DP. Adrenergic agonists and antagonists. In: Brunton LL, ed. Goodman and Gilman's the Pharmacological Basis of Therapeutics, 11th eds. New York: McGraw-Hill, 2006; pp. 215-68.
5. Kemp SF, Lockey RF, Simons FE. Epinephrine: the drug of choice for anaphylaxis. A statement of the World Allergy Organization. Allergy 2008; 63: 1061-70.
6. Bock SA, Muñoz-Furlong A, Sampson HA. Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol 2001; 107: 191-3.
7. Gold MS, Sainsbury R. First aid anaphylaxis management in children who were prescribed an epinephrine autoinjector device (EpiPen). J Allergy Clin Immunol 2000; 106: 171-6.
8. Simons FER. Lack of worldwide availability of epinephrine autoinjectors for outpatients at risk of anaphylaxis. Ann Allergy Asthma Immunol 2005; 94: 534-8.
9. Simons FER, Chan ES, Gu X, Simons KJ. Epinephrine for the out-of-hospital (first aid) treatment of anaphylaxis in infants: is the ampoule/syringe/needle method practical? J Allergy Clin Immunol 2001; 108: 1040-4.
10. Sicherer SH, Simons FER. Self injectable epinephrine for first-aid management of anaphylaxis. Pediatrics 2007; 19: 638-46.
11. Kirchhoefer RD, Thornton LK, Allgire JF. Stability of sterile aqueous epinephrine injections submitted by U.S. hospitals. Am J Hosp Pharm 1986; 43: 1741-6.
12. Sampson HA. Anaphylaxis and emergency treatment. Pediatrics. 2003; 111: 1601-8.
13. Simons FE, Peterson S, Black CD. Epinephrine dispensing for the out-of-hospital treatment of anaphylaxis in infants and children: a population-based study. Ann Allergy Asthma Immunol 2001; 86: 622-6.
14. Kelly JR, Dalm GW: Stability of epinephrine in dental anesthetic solutions: Implications for autoclave sterilization and elevated temperature storage. Mil Med 1985; 150: 112-5.
15. Fry BW, Ciarlone AE. Storage at body temperature alters concentration of vasoconstrictors in local anesthetics. J Dent Res 1980; 59: 1069.
16. Church WH, Hu SS, Henry AJ. Thermal degradation of injectable epinephrine. Am J Emerg Med 1994; 12: 306-9.
17. Rawas-Qalaji M, Simons FE, Collins D, Simons KJ. Longterm stability of epinephrine dispensed in unsealed syringes for the first-aid treatment of anaphylaxis. Ann Allergy Asthma Immunol 2009; 102: 500-3.
18. Rudland SV, Annus T, Dickinson J, Langdon S. Adrenaline degradation in general practice. Br J Gen Pract 1997; 47: 827-8.